Chlorine in PDB 1y6q: Cyrstal Structure of Mta/Adohcy Nucleosidase Complexed with Mt-Dadme-Imma

All present enzymatic activity of Cyrstal Structure of Mta/Adohcy Nucleosidase Complexed with Mt-Dadme-Imma:
3.2.2.16; 3.2.2.9;

The structure of Cyrstal Structure of Mta/Adohcy Nucleosidase Complexed with Mt-Dadme-Imma, PDB code: 1y6q was solved by J.E.Lee, V.Singh, G.B.Evans, P.C.Tyler, R.H.Furneaux, K.A.Cornell, M.K.Riscoe, V.L.Schramm, P.L.Howell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.22 / 2.20
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	51.710, 69.790, 128.340, 90.00, 90.00, 90.00
R / Rfree (%)	19.8 / 24.6

The binding sites of Chlorine atom in the Cyrstal Structure of Mta/Adohcy Nucleosidase Complexed with Mt-Dadme-Imma (pdb code 1y6q). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Cyrstal Structure of Mta/Adohcy Nucleosidase Complexed with Mt-Dadme-Imma, PDB code: 1y6q:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Cyrstal Structure of Mta/Adohcy Nucleosidase Complexed with Mt-Dadme-Imma


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cyrstal Structure of Mta/Adohcy Nucleosidase Complexed with Mt-Dadme-Imma within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl302 b:33.5 occ:1.00 N A:GLN167 3.1 32.8 1.0 CB A:GLN167 3.5 38.4 1.0 C A:PHE165 3.7 29.7 1.0 CD A:PRO166 3.7 30.6 1.0 CA A:GLN167 3.7 34.0 1.0 CA A:PHE165 3.7 29.6 1.0 N A:PRO166 3.7 29.6 1.0 CD2 A:LEU144 3.8 26.1 1.0 N A:ALA168 4.0 28.9 1.0 C A:GLN167 4.1 32.2 1.0 CB A:PHE165 4.1 27.4 1.0 C A:PRO166 4.2 32.5 1.0 O A:PHE165 4.2 27.4 1.0 CA A:PRO166 4.4 32.8 1.0 CD1 A:PHE165 4.6 24.4 1.0 CG A:GLN167 4.8 49.2 1.0 CB A:PRO166 4.8 31.1 1.0 CG A:PRO166 4.8 34.1 1.0 CG A:PHE165 4.9 23.2 1.0 O A:ASN164 4.9 25.6 1.0 O A:GLN167 4.9 31.4 1.0 CD A:GLN167 4.9 53.2 1.0 N A:PHE165 5.0 27.7 1.0

Chlorine binding site 2 out of 2 in the Cyrstal Structure of Mta/Adohcy Nucleosidase Complexed with Mt-Dadme-Imma


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cyrstal Structure of Mta/Adohcy Nucleosidase Complexed with Mt-Dadme-Imma within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl301 b:28.1 occ:1.00 N B:GLN167 3.1 25.4 1.0 O B:HOH551 3.3 27.3 1.0 CA B:PHE165 3.5 26.1 1.0 O B:HOH616 3.5 33.2 1.0 C B:PHE165 3.5 26.2 1.0 CB B:GLN167 3.6 31.3 1.0 N B:PRO166 3.6 26.0 1.0 CA B:GLN167 3.8 24.1 1.0 CD B:PRO166 3.8 24.8 1.0 CB B:PHE165 4.0 23.6 1.0 CD2 B:LEU144 4.0 19.4 1.0 N B:ALA168 4.0 23.9 1.0 CG B:PRO166 4.1 28.4 1.0 O B:PHE165 4.1 23.7 1.0 C B:GLN167 4.2 23.9 1.0 C B:PRO166 4.2 24.5 1.0 CG B:GLN167 4.3 39.2 1.0 CA B:PRO166 4.4 24.9 1.0 O B:ASN164 4.6 21.1 1.0 CD2 B:PHE165 4.7 25.7 1.0 N B:PHE165 4.8 25.5 1.0 O B:HOH485 4.8 28.5 1.0 CG B:PHE165 4.8 28.0 1.0 CB B:PRO166 5.0 26.1 1.0

J.E.Lee, V.Singh, G.B.Evans, P.C.Tyler, R.H.Furneaux, K.A.Cornell, M.K.Riscoe, V.L.Schramm, P.L.Howell. Structural Rationale For the Affinity of Pico- and Femtomolar Transition State Analogues of Escherichia Coli 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase. J.Biol.Chem. V. 280 18274 2005.
ISSN: ISSN 0021-9258
PubMed: 15746096
DOI: 10.1074/JBC.M414471200