Chlorine in PDB 2uxn: Structural Basis of Histone Demethylation By LSD1 Revealed By Suicide Inactivation

The structure of Structural Basis of Histone Demethylation By LSD1 Revealed By Suicide Inactivation, PDB code: 2uxn was solved by M.Yang, J.C.Culhane, L.M.Szewczuk, C.B.Gocke, C.A.Brautigam, D.R.Tomchick, M.Machius, P.A.Cole, H.Yu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.00 / 2.72
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	119.949, 178.646, 234.930, 90.00, 90.00, 90.00
R / Rfree (%)	24.1 / 27.2

The binding sites of Chlorine atom in the Structural Basis of Histone Demethylation By LSD1 Revealed By Suicide Inactivation (pdb code 2uxn). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structural Basis of Histone Demethylation By LSD1 Revealed By Suicide Inactivation, PDB code: 2uxn:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Structural Basis of Histone Demethylation By LSD1 Revealed By Suicide Inactivation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structural Basis of Histone Demethylation By LSD1 Revealed By Suicide Inactivation within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1838 b:0.1 occ:1.00 CD2 A:TRP646 4.4 42.2 1.0 CE2 A:TRP646 4.4 41.4 1.0 CD2 A:LEU775 4.5 42.8 1.0 CE3 A:TRP646 4.6 41.6 1.0 CZ2 A:TRP646 4.7 41.3 1.0 CG A:TRP646 4.7 43.6 1.0 NE1 A:TRP646 4.8 42.1 1.0 CZ3 A:TRP646 4.9 41.7 1.0 CH2 A:TRP646 4.9 41.9 1.0 CD1 A:TRP646 5.0 42.6 1.0

Chlorine binding site 2 out of 2 in the Structural Basis of Histone Demethylation By LSD1 Revealed By Suicide Inactivation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structural Basis of Histone Demethylation By LSD1 Revealed By Suicide Inactivation within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1839 b:87.3 occ:1.00 OD2 A:ASP754 3.6 52.3 1.0 CE2 A:TRP751 4.1 50.0 1.0 CH2 A:TRP751 4.1 50.6 1.0 CZ2 A:TRP751 4.1 50.4 1.0 CZ3 A:TRP751 4.2 50.1 1.0 CD2 A:TRP751 4.2 49.9 1.0 CE3 A:TRP751 4.2 49.8 1.0 N A:ARG750 4.3 59.2 1.0 O A:ARG750 4.5 56.7 1.0 CG A:ASP754 4.5 51.7 1.0 C A:ARG750 4.6 56.5 1.0 CB A:SER749 4.6 61.1 1.0 CB A:ASP754 4.7 51.5 1.0 CA A:SER749 4.7 61.8 1.0 NE1 A:TRP751 4.8 51.0 1.0 CG A:TRP751 4.8 51.1 1.0 N A:TRP751 4.9 54.5 1.0

M.Yang, J.C.Culhane, L.M.Szewczuk, C.B.Gocke, C.A.Brautigam, D.R.Tomchick, M.Machius, P.A.Cole, H.Yu. Structural Basis of Histone Demethylation By LSD1 Revealed By Suicide Inactivation. Nat.Struct.Mol.Biol. V. 14 535 2007.
ISSN: ISSN 1545-9993
PubMed: 17529991
DOI: 10.1038/NSMB1255