Chlorine in PDB 3bpr: Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52
Enzymatic activity of Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52
All present enzymatic activity of Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52, PDB code: 3bpr
was solved by
J.R.Walker,
X.Huang,
P.J.Finerty Jr,
J.Weigelt,
C.H.Arrowsmith,
A.M.Edwards,
A.Bochkarev,
S.Dhe-Paganon,
Structural Genomics Consortium(Sgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 47.30 / 2.80 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 70.001, 91.702, 120.745, 90.00, 94.06, 90.00 |
| R / Rfree (%) | 27.4 / 30.1 |
Other elements in 3bpr:
The structure of Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52 also contains other interesting chemical elements:
| Sodium | (Na) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52
(pdb code 3bpr). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52, PDB code: 3bpr:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Chlorine where determined in the Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52, PDB code: 3bpr:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;
Chlorine binding site 1 out of 6 in 3bpr
Go back to
Chlorine Binding Sites List in 3bpr
Chlorine binding site 1 out
of 6 in the Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52 within 5.0Å range:
|
Chlorine binding site 2 out of 6 in 3bpr
Go back to
Chlorine Binding Sites List in 3bpr
Chlorine binding site 2 out
of 6 in the Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52 within 5.0Å range:
|
Chlorine binding site 3 out of 6 in 3bpr
Go back to
Chlorine Binding Sites List in 3bpr
Chlorine binding site 3 out
of 6 in the Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52 within 5.0Å range:
|
Chlorine binding site 4 out of 6 in 3bpr
Go back to
Chlorine Binding Sites List in 3bpr
Chlorine binding site 4 out
of 6 in the Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52 within 5.0Å range:
|
Chlorine binding site 5 out of 6 in 3bpr
Go back to
Chlorine Binding Sites List in 3bpr
Chlorine binding site 5 out
of 6 in the Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 5 of Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52 within 5.0Å range:
|
Chlorine binding site 6 out of 6 in 3bpr
Go back to
Chlorine Binding Sites List in 3bpr
Chlorine binding site 6 out
of 6 in the Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 6 of Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52 within 5.0Å range:
|
Reference:
X.Huang,
P.Finerty,
J.R.Walker,
C.Butler-Cole,
M.Vedadi,
M.Schapira,
S.A.Parker,
B.E.Turk,
D.A.Thompson,
S.Dhe-Paganon.
Structural Insights Into the Inhibited States of the Mer Receptor Tyrosine Kinase. J.Struct.Biol. V. 165 88 2009.
ISSN: ISSN 1047-8477
PubMed: 19028587
DOI: 10.1016/J.JSB.2008.10.003
Page generated: Sat Jul 20 16:38:55 2024
ISSN: ISSN 1047-8477
PubMed: 19028587
DOI: 10.1016/J.JSB.2008.10.003
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