Chlorine in PDB 3th3: MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+

Enzymatic activity of MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+

All present enzymatic activity of MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+:
3.4.21.21;

Protein crystallography data

The structure of MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+, PDB code: 3th3 was solved by K.Vadivel, S.Agah, D.Cascio, K.Padmanabhan, S.P.Bajaj, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	55.01 / 2.70
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	78.079, 68.894, 79.153, 90.00, 91.19, 90.00
*R / R_free (%)*	22.8 / 29.8

Other elements in 3th3:

The structure of MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+ also contains other interesting chemical elements:

Calcium

(Ca)

2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+ (pdb code 3th3). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+, PDB code: 3th3:

Chlorine binding site 1 out of 1 in 3th3

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Chlorine Binding Sites List in 3th3

Chlorine binding site 1 out of 1 in the MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+ within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
H:Cl303 b:39.6 occ:1.00	N	H:ARG84	3.1	39.7	1.0
	CB	H:HIS109	3.5	38.3	1.0
	CG	H:ARG84	3.6	46.9	1.0
	ND1	H:HIS109	3.7	43.7	1.0
	CA	H:ARG83	3.8	37.5	1.0
	CB	H:ARG84	3.9	41.6	1.0
	C	H:ARG83	3.9	38.6	1.0
	CD	H:ARG83	4.0	34.1	1.0
	CG	H:GLN110	4.0	40.5	1.0
	CA	H:ARG84	4.0	40.6	1.0
	CG	H:HIS109	4.0	41.0	1.0
	CB	H:ARG83	4.1	37.3	1.0
	N	H:GLN110	4.2	34.5	1.0
	CB	H:GLN110	4.4	34.0	1.0
	CA	H:HIS109	4.5	36.8	1.0
	O	H:ARG84	4.5	39.4	1.0
	C	H:HIS109	4.6	35.1	1.0
	CD	H:GLN110	4.6	46.3	1.0
	CG	H:ARG83	4.7	36.3	1.0
	NE2	H:GLN110	4.7	45.5	1.0
	C	H:ARG84	4.8	40.0	1.0
	N	H:HIS109	4.8	36.8	1.0
	CE1	H:HIS109	4.9	44.2	1.0
	CA	H:GLN110	4.9	33.7	1.0
	CD	H:ARG84	5.0	56.7	1.0

Reference:

K.Vadivel, S.Agah, A.Messer, D.Cascio, M.S.Bajaj, S.Krishnaswamy, C.T.Esmon, K.Padmanabhan, S.P.Bajaj. MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+ To Be Published.

Page generated: Sat Dec 12 10:12:07 2020

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