Chlorine in PDB 3th3: MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+

Enzymatic activity of MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+

All present enzymatic activity of MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+:
3.4.21.21;

Protein crystallography data

The structure of MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+, PDB code: 3th3 was solved by K.Vadivel, S.Agah, D.Cascio, K.Padmanabhan, S.P.Bajaj, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 55.01 / 2.70
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 78.079, 68.894, 79.153, 90.00, 91.19, 90.00
R / Rfree (%) 22.8 / 29.8

Other elements in 3th3:

The structure of MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+ also contains other interesting chemical elements:

Calcium (Ca) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+ (pdb code 3th3). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+, PDB code: 3th3:

Chlorine binding site 1 out of 1 in 3th3

Go back to Chlorine Binding Sites List in 3th3
Chlorine binding site 1 out of 1 in the MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+ within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Cl303

b:39.6
occ:1.00
 N H:ARG84 3.1 39.7 1.0
CB H:HIS109 3.5 38.3 1.0
CG H:ARG84 3.6 46.9 1.0
ND1 H:HIS109 3.7 43.7 1.0
CA H:ARG83 3.8 37.5 1.0
CB H:ARG84 3.9 41.6 1.0
C H:ARG83 3.9 38.6 1.0
CD H:ARG83 4.0 34.1 1.0
CG H:GLN110 4.0 40.5 1.0
CA H:ARG84 4.0 40.6 1.0
CG H:HIS109 4.0 41.0 1.0
CB H:ARG83 4.1 37.3 1.0
N H:GLN110 4.2 34.5 1.0
CB H:GLN110 4.4 34.0 1.0
CA H:HIS109 4.5 36.8 1.0
O H:ARG84 4.5 39.4 1.0
C H:HIS109 4.6 35.1 1.0
CD H:GLN110 4.6 46.3 1.0
CG H:ARG83 4.7 36.3 1.0
NE2 H:GLN110 4.7 45.5 1.0
C H:ARG84 4.8 40.0 1.0
N H:HIS109 4.8 36.8 1.0
CE1 H:HIS109 4.9 44.2 1.0
CA H:GLN110 4.9 33.7 1.0
CD H:ARG84 5.0 56.7 1.0

Reference:

K.Vadivel, S.Agah, A.Messer, D.Cascio, M.S.Bajaj, S.Krishnaswamy, C.T.Esmon, K.Padmanabhan, S.P.Bajaj. MG2+ Is Required For Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors at Physiological CA2+ To Be Published.
Page generated: Sun Jul 21 05:12:40 2024

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