Chlorine in PDB 4xg8: Crystal Structure of An Inhibitor-Bound Syk

All present enzymatic activity of Crystal Structure of An Inhibitor-Bound Syk:
2.7.10.2;

The structure of Crystal Structure of An Inhibitor-Bound Syk, PDB code: 4xg8 was solved by S.J.Lee, J.Choi, B.G.Han, H.Song, J.S.Koh, B.I.Lee, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.11 / 2.40
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	39.964, 42.212, 87.720, 99.97, 90.50, 101.05
R / Rfree (%)	24.7 / 27.5

The binding sites of Chlorine atom in the Crystal Structure of An Inhibitor-Bound Syk (pdb code 4xg8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of An Inhibitor-Bound Syk, PDB code: 4xg8:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of An Inhibitor-Bound Syk


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of An Inhibitor-Bound Syk within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl700 b:93.2 occ:1.00 CL1 A:X8G700 0.0 93.2 1.0 CAV A:X8G700 1.7 67.1 1.0 NAQ A:X8G700 2.7 62.8 1.0 CAY A:X8G700 2.7 61.1 1.0 CAI A:X8G700 3.4 59.4 1.0 NBC A:X8G700 3.6 59.1 1.0 CAZ A:X8G700 3.7 61.2 1.0 CD2 A:LEU377 3.9 73.3 1.0 CD A:PRO455 4.3 47.5 1.0 O A:LEU377 4.4 83.5 1.0 CB A:LEU377 4.6 78.8 1.0 CA A:GLY454 4.7 52.9 1.0 CAT A:X8G700 4.7 53.5 1.0 C A:LEU377 4.8 81.6 1.0 CAH A:X8G700 4.8 60.8 1.0 CG A:LEU377 4.9 72.4 1.0 CA A:LEU377 4.9 80.1 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of An Inhibitor-Bound Syk


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of An Inhibitor-Bound Syk within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl700 b:97.8 occ:1.00 CL1 C:X8G700 0.0 97.8 1.0 CAV C:X8G700 1.7 72.8 1.0 NAQ C:X8G700 2.6 67.5 1.0 CAY C:X8G700 2.7 69.8 1.0 CAI C:X8G700 3.4 63.2 1.0 NBC C:X8G700 3.5 65.4 1.0 CAZ C:X8G700 3.6 68.4 1.0 CD C:PRO455 4.3 39.6 1.0 CA C:GLY454 4.4 45.0 1.0 O C:LEU453 4.5 51.2 1.0 O C:LEU377 4.6 60.4 1.0 CAT C:X8G700 4.8 55.0 1.0 CD2 C:LEU377 4.8 67.5 1.0 O C:GLU452 4.8 43.9 1.0 CAH C:X8G700 4.9 70.6 1.0 C C:LEU453 4.9 50.0 1.0 N C:GLY454 4.9 48.0 1.0 CB C:LEU377 4.9 69.0 1.0 CAB C:X8G700 5.0 61.8 1.0

S.J.Lee, J.S.Choi, B.G.Han, H.S.Kim, H.J.Song, J.Lee, S.Nam, S.H.Goh, J.H.Kim, J.S.Koh, B.I.Lee. Crystal Structures of Spleen Tyrosine Kinase in Complex with Novel Inhibitors: Structural Insights For Design of Anticancer Drugs Febs J. V. 283 3613 2016.
ISSN: ISSN 1742-464X
PubMed: 27504936
DOI: 10.1111/FEBS.13831