Chlorine in PDB 5wkv: Structure of An Acid Sensing Ion Channel in A Resting State with Calcium

The structure of Structure of An Acid Sensing Ion Channel in A Resting State with Calcium, PDB code: 5wkv was solved by N.Yoder, E.Gouaux, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.95 / 3.20
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	109.180, 133.700, 157.650, 90.00, 90.00, 90.00
R / Rfree (%)	28.7 / 29.7

The structure of Structure of An Acid Sensing Ion Channel in A Resting State with Calcium also contains other interesting chemical elements:

Calcium

(Ca)

6 atoms

The binding sites of Chlorine atom in the Structure of An Acid Sensing Ion Channel in A Resting State with Calcium (pdb code 5wkv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of An Acid Sensing Ion Channel in A Resting State with Calcium, PDB code: 5wkv:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Structure of An Acid Sensing Ion Channel in A Resting State with Calcium


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of An Acid Sensing Ion Channel in A Resting State with Calcium within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl503 b:0.5 occ:0.89 NZ A:LYS422 3.1 0.8 1.0 NZ A:LYS77 3.4 0.6 1.0 CB B:PRO73 3.8 0.9 1.0 CA B:PRO73 3.8 0.5 1.0 CE A:LYS77 4.2 0.5 1.0 CD A:LYS77 4.2 0.6 1.0 CE A:LYS422 4.5 0.2 1.0 N B:HIS74 4.6 0.8 1.0 N B:PRO73 4.8 0.7 1.0 C B:PRO73 4.8 0.0 1.0 O B:LEU71 5.0 0.5 1.0 O B:HIS74 5.0 1.0 1.0

Chlorine binding site 2 out of 2 in the Structure of An Acid Sensing Ion Channel in A Resting State with Calcium


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of An Acid Sensing Ion Channel in A Resting State with Calcium within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl504 b:0.3 occ:0.81 NZ B:LYS422 2.7 0.9 1.0 CE B:LYS422 3.7 0.3 1.0 CD B:LYS422 4.2 0.8 1.0 CB C:PRO73 4.3 0.3 1.0 CD1 C:LEU71 4.7 0.5 1.0 NZ B:LYS77 4.8 0.7 1.0

N.Yoder, C.Yoshioka, E.Gouaux. Gating Mechanisms of Acid-Sensing Ion Channels. Nature V. 555 397 2018.
ISSN: ESSN 1476-4687
PubMed: 29513651
DOI: 10.1038/NATURE25782