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Chlorine in PDB 6p8z: Crystal Structure of Human Kras G12C Covalently Bound to An Acryloylazetidine Acetamide InhibitorProtein crystallography data
The structure of Crystal Structure of Human Kras G12C Covalently Bound to An Acryloylazetidine Acetamide Inhibitor, PDB code: 6p8z
was solved by
C.Mohr,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6p8z:
The structure of Crystal Structure of Human Kras G12C Covalently Bound to An Acryloylazetidine Acetamide Inhibitor also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human Kras G12C Covalently Bound to An Acryloylazetidine Acetamide Inhibitor
(pdb code 6p8z). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Kras G12C Covalently Bound to An Acryloylazetidine Acetamide Inhibitor, PDB code: 6p8z: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 6p8zGo back to Chlorine Binding Sites List in 6p8z
Chlorine binding site 1 out
of 2 in the Crystal Structure of Human Kras G12C Covalently Bound to An Acryloylazetidine Acetamide Inhibitor
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 6p8zGo back to Chlorine Binding Sites List in 6p8z
Chlorine binding site 2 out
of 2 in the Crystal Structure of Human Kras G12C Covalently Bound to An Acryloylazetidine Acetamide Inhibitor
Mono view Stereo pair view
Reference:
Y.Shin,
J.W.Jeong,
R.P.Wurz,
P.Achanta,
T.Arvedson,
M.D.Bartberger,
I.D.G.Campuzano,
R.Fucini,
S.K.Hansen,
J.Ingersoll,
J.S.Iwig,
J.R.Lipford,
V.Ma,
D.J.Kopecky,
J.Mccarter,
T.San Miguel,
C.Mohr,
S.Sabet,
A.Y.Saiki,
A.Sawayama,
S.Sethofer,
C.M.Tegley,
L.P.Volak,
K.Yang,
B.A.Lanman,
D.A.Erlanson,
V.J.Cee.
Discovery Ofn-(1-Acryloylazetidin-3-Yl)-2-(1H-Indol-1-Yl) Acetamides As Covalent Inhibitors of KRASG12C. Acs Med.Chem.Lett. V. 10 1302 2019.
Page generated: Sat Dec 12 13:29:16 2020
ISSN: ISSN 1948-5875 PubMed: 31531201 DOI: 10.1021/ACSMEDCHEMLETT.9B00258 |
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