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Chlorine in PDB 6yxi: Structure of Notum in Complex with A 1-(3-Chlorophenyl)-2,5-Dimethyl- 1H-Pyrrole-3-Carboxylic Acid InhibitorEnzymatic activity of Structure of Notum in Complex with A 1-(3-Chlorophenyl)-2,5-Dimethyl- 1H-Pyrrole-3-Carboxylic Acid Inhibitor
All present enzymatic activity of Structure of Notum in Complex with A 1-(3-Chlorophenyl)-2,5-Dimethyl- 1H-Pyrrole-3-Carboxylic Acid Inhibitor:
3.1.1.98; Protein crystallography data
The structure of Structure of Notum in Complex with A 1-(3-Chlorophenyl)-2,5-Dimethyl- 1H-Pyrrole-3-Carboxylic Acid Inhibitor, PDB code: 6yxi
was solved by
L.Vecchia,
E.Y.Jones,
R.R.Ruza,
J.Hillier,
Y.Zhao,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of Notum in Complex with A 1-(3-Chlorophenyl)-2,5-Dimethyl- 1H-Pyrrole-3-Carboxylic Acid Inhibitor
(pdb code 6yxi). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of Notum in Complex with A 1-(3-Chlorophenyl)-2,5-Dimethyl- 1H-Pyrrole-3-Carboxylic Acid Inhibitor, PDB code: 6yxi: Chlorine binding site 1 out of 1 in 6yxiGo back to Chlorine Binding Sites List in 6yxi
Chlorine binding site 1 out
of 1 in the Structure of Notum in Complex with A 1-(3-Chlorophenyl)-2,5-Dimethyl- 1H-Pyrrole-3-Carboxylic Acid Inhibitor
Mono view Stereo pair view
Reference:
W.Mahy,
M.Patel,
D.Steadman,
H.L.Woodward,
B.N.Atkinson,
F.Svensson,
N.J.Willis,
A.Flint,
D.Papatheodorou,
Y.Zhao,
L.Vecchia,
R.R.Ruza,
J.Hillier,
S.Frew,
A.Monaghan,
A.Costa,
M.Bictash,
M.W.Walter,
E.Y.Jones,
P.V.Fish.
Screening of A Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines As Inhibitors of Notum Carboxylesterase Activity. J.Med.Chem. V. 63 9464 2020.
Page generated: Sat Dec 12 14:44:51 2020
ISSN: ISSN 0022-2623 PubMed: 32787107 DOI: 10.1021/ACS.JMEDCHEM.0C00660 |
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