Chlorine in PDB 7jhn: Structure of Human Beta 1,3-N-Acetylglucosaminyltransferase 2 with Udp and Trisaccharide Glcnac-BETA1-3GAL-BETA1-4GLCNAC

Enzymatic activity of Structure of Human Beta 1,3-N-Acetylglucosaminyltransferase 2 with Udp and Trisaccharide Glcnac-BETA1-3GAL-BETA1-4GLCNAC

All present enzymatic activity of Structure of Human Beta 1,3-N-Acetylglucosaminyltransferase 2 with Udp and Trisaccharide Glcnac-BETA1-3GAL-BETA1-4GLCNAC:
2.4.1.149;

Protein crystallography data

The structure of Structure of Human Beta 1,3-N-Acetylglucosaminyltransferase 2 with Udp and Trisaccharide Glcnac-BETA1-3GAL-BETA1-4GLCNAC, PDB code: 7jhn was solved by Y.Hao, X.Huang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.89 / 2.20
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 82.916, 76.865, 66.786, 90.00, 105.82, 90.00
R / Rfree (%) 19.6 / 25.5

Other elements in 7jhn:

The structure of Structure of Human Beta 1,3-N-Acetylglucosaminyltransferase 2 with Udp and Trisaccharide Glcnac-BETA1-3GAL-BETA1-4GLCNAC also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structure of Human Beta 1,3-N-Acetylglucosaminyltransferase 2 with Udp and Trisaccharide Glcnac-BETA1-3GAL-BETA1-4GLCNAC (pdb code 7jhn). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of Human Beta 1,3-N-Acetylglucosaminyltransferase 2 with Udp and Trisaccharide Glcnac-BETA1-3GAL-BETA1-4GLCNAC, PDB code: 7jhn:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 7jhn

Go back to Chlorine Binding Sites List in 7jhn
Chlorine binding site 1 out of 2 in the Structure of Human Beta 1,3-N-Acetylglucosaminyltransferase 2 with Udp and Trisaccharide Glcnac-BETA1-3GAL-BETA1-4GLCNAC


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Human Beta 1,3-N-Acetylglucosaminyltransferase 2 with Udp and Trisaccharide Glcnac-BETA1-3GAL-BETA1-4GLCNAC within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl404

b:65.2
occ:1.00
 O A:HOH593 3.2 45.8 1.0
ND1 A:HIS205 3.8 34.7 1.0
NH2 A:ARG178 3.8 27.4 1.0
CE1 A:HIS205 4.7 27.0 1.0
CG A:HIS205 4.7 34.0 1.0
CD A:ARG162 4.7 28.7 1.0
CB A:HIS205 4.7 37.7 1.0
O A:HIS205 4.8 57.7 1.0
CA A:HIS205 4.8 35.7 1.0
CZ A:ARG178 4.9 24.0 1.0

Chlorine binding site 2 out of 2 in 7jhn

Go back to Chlorine Binding Sites List in 7jhn
Chlorine binding site 2 out of 2 in the Structure of Human Beta 1,3-N-Acetylglucosaminyltransferase 2 with Udp and Trisaccharide Glcnac-BETA1-3GAL-BETA1-4GLCNAC


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of Human Beta 1,3-N-Acetylglucosaminyltransferase 2 with Udp and Trisaccharide Glcnac-BETA1-3GAL-BETA1-4GLCNAC within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl405

b:69.7
occ:1.00
 O A:HOH599 3.0 41.2 1.0
O A:HOH585 3.4 20.1 1.0
O A:HOH600 4.0 25.9 1.0
CG A:LYS379 4.3 23.9 1.0
O A:HOH604 4.4 38.3 0.5
NE A:ARG157 4.4 28.8 1.0
NH2 A:ARG157 4.4 28.7 1.0
CE A:LYS379 4.5 59.5 1.0
CD A:PRO380 4.5 14.8 1.0
CZ A:ARG157 4.7 22.1 1.0
CD A:LYS379 4.8 31.5 1.0
CB A:LYS379 5.0 11.5 1.0

Reference:

Y.Hao, A.Crequer-Grandhomme, N.Javier, A.Singh, H.Chen, P.Manzanillo, M.C.Lo, X.Huang. Structures and Mechanism of Human Glycosyltransferase Beta 1,3-N-Acetylglucosaminyltransferase 2 (B3GNT2), An Important Player in Immune Homeostasis. J.Biol.Chem. 2020.
ISSN: ESSN 1083-351X
PubMed: 33158990
DOI: 10.1074/JBC.RA120.015306
Page generated: Sun Dec 13 10:29:52 2020

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