Chlorine in PDB 7jjm: Crystal Structure of Importin Alpha 2 in Complex with LSD1 Nls

Enzymatic activity of Crystal Structure of Importin Alpha 2 in Complex with LSD1 Nls

All present enzymatic activity of Crystal Structure of Importin Alpha 2 in Complex with LSD1 Nls:
1.14.99.66;

Protein crystallography data

The structure of Crystal Structure of Importin Alpha 2 in Complex with LSD1 Nls, PDB code: 7jjm was solved by W.J.Tu, R.Mcguaig, H.Y.A.Tan, C.Hardy, N.Seddiki, S.Ali, J.E.Dahlstrom, E.G.Bean, J.Dunn, J.K.Forwood, S.Tsimbalyuk, K.M.Smith, D.Yip, L.Malik, T.Prasana, P.Milburn, S.Rao, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 41.04 / 2.06
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 78.610, 90.050, 99.750, 90.00, 90.00, 90.00
R / Rfree (%) 22 / 25.9

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Importin Alpha 2 in Complex with LSD1 Nls (pdb code 7jjm). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Importin Alpha 2 in Complex with LSD1 Nls, PDB code: 7jjm:

Chlorine binding site 1 out of 1 in 7jjm

Go back to Chlorine Binding Sites List in 7jjm
Chlorine binding site 1 out of 1 in the Crystal Structure of Importin Alpha 2 in Complex with LSD1 Nls


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Importin Alpha 2 in Complex with LSD1 Nls within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl601

b:60.9
occ:1.00
HB3 B:HIS418 3.1 51.4 1.0
CG B:HIS418 3.7 58.4 1.0
CB B:HIS418 3.9 42.8 1.0
CD2 B:HIS418 3.9 63.8 1.0
HD2 B:HIS418 4.1 76.5 1.0
ND1 B:HIS418 4.2 66.4 1.0
HB2 B:HIS418 4.5 51.4 1.0
NE2 B:HIS418 4.5 56.8 1.0
CE1 B:HIS418 4.7 65.2 1.0
HA B:HIS418 4.7 50.5 1.0
CA B:HIS418 4.9 42.1 1.0
O B:HIS418 4.9 45.9 1.0
HE2 B:HIS418 5.0 68.1 1.0

Reference:

W.J.Tu, R.D.Mccuaig, A.H.Y.Tan, K.Hardy, N.Seddiki, S.Ali, J.E.Dahlstrom, E.G.Bean, J.Dunn, J.Forwood, S.Tsimbalyuk, K.Smith, D.Yip, L.Malik, T.Prasanna, P.Milburn, S.Rao. Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells Via A Novel LSD1-Eomes Switch. Front Immunol V. 11 1228 2020.
ISSN: ESSN 1664-3224
DOI: 10.3389/FIMMU.2020.01228
Page generated: Mon Jul 29 23:08:16 2024

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