Chlorine in PDB 7jm7: Structure of Human Clc-7/OSTM1 Complex

The structure of Structure of Human Clc-7/OSTM1 Complex also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Chlorine atom in the Structure of Human Clc-7/OSTM1 Complex (pdb code 7jm7). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Structure of Human Clc-7/OSTM1 Complex, PDB code: 7jm7:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;

Chlorine binding site 1 out of 6 in the Structure of Human Clc-7/OSTM1 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Human Clc-7/OSTM1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl903 b:47.7 occ:1.00 HH A:TYR602 2.3 36.9 1.0 H A:VAL513 2.4 39.5 1.0 HD12 A:ILE206 2.7 36.2 1.0 HG12 A:VAL513 2.7 39.5 1.0 OH A:TYR602 2.8 36.9 1.0 HB3 A:SER204 2.9 38.0 1.0 HB2 A:SER204 3.0 38.0 1.0 HG A:SER204 3.1 38.0 1.0 HA2 A:GLY512 3.2 39.1 1.0 N A:VAL513 3.2 39.5 1.0 HA3 A:GLY248 3.2 38.6 1.0 CB A:SER204 3.3 38.0 1.0 H A:PHE514 3.3 38.8 1.0 CD1 A:ILE206 3.5 36.2 1.0 HD11 A:ILE206 3.5 36.2 1.0 OG A:SER204 3.6 38.0 1.0 CG1 A:VAL513 3.7 39.5 1.0 HA3 A:GLY512 3.8 39.1 1.0 CA A:GLY512 3.8 39.1 1.0 HD13 A:ILE206 3.9 36.2 1.0 N A:PHE514 3.9 38.8 1.0 CD2 A:PHE514 3.9 38.8 1.0 C A:GLY512 4.0 39.1 1.0 CE2 A:PHE514 4.0 38.8 1.0 CZ A:TYR602 4.1 36.9 1.0 CG A:PHE514 4.1 38.8 1.0 HG13 A:VAL513 4.1 39.5 1.0 CA A:VAL513 4.1 39.5 1.0 HE1 A:TYR602 4.1 36.9 1.0 HD2 A:PHE514 4.2 38.8 1.0 CA A:GLY248 4.2 38.6 1.0 HG11 A:VAL513 4.2 39.5 1.0 CZ A:PHE514 4.3 38.8 1.0 HE2 A:PHE514 4.3 38.8 1.0 CD1 A:PHE514 4.3 38.8 1.0 CB A:VAL513 4.4 39.5 1.0 C A:VAL513 4.4 39.5 1.0 HA2 A:GLY248 4.4 38.6 1.0 H A:GLY248 4.4 38.6 1.0 HB A:VAL513 4.4 39.5 1.0 CE1 A:PHE514 4.4 38.8 1.0 CL A:CL904 4.5 42.6 1.0 HB2 A:PHE514 4.5 38.8 1.0 CE1 A:TYR602 4.5 36.9 1.0 HD3 A:PRO249 4.6 37.9 1.0 HB A:ILE206 4.7 36.2 1.0 CB A:PHE514 4.7 38.8 1.0 HE1 A:TYR505 4.7 39.4 1.0 CG1 A:ILE206 4.7 36.2 1.0 CA A:SER204 4.7 38.0 1.0 HZ A:PHE514 4.7 38.8 1.0 HG13 A:ILE206 4.8 36.2 1.0 N A:GLY248 4.8 38.6 1.0 HD1 A:PHE514 4.8 38.8 1.0 CA A:PHE514 4.9 38.8 1.0 HA A:SER204 4.9 38.0 1.0 HE1 A:PHE514 5.0 38.8 1.0 HA A:VAL513 5.0 39.5 1.0

Chlorine binding site 2 out of 6 in the Structure of Human Clc-7/OSTM1 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of Human Clc-7/OSTM1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl904 b:42.6 occ:1.00 HB2 A:PHE514 2.7 38.8 1.0 H A:ILE515 2.8 40.9 1.0 H A:PHE514 2.8 38.8 1.0 H A:GLY248 2.8 38.6 1.0 HA3 A:GLY245 2.8 38.1 1.0 HG12 A:ILE515 2.8 40.9 1.0 HA3 A:GLY512 2.9 39.1 1.0 H A:GLU247 3.0 41.4 1.0 HB2 A:GLU247 3.1 41.4 1.0 HG2 A:GLU247 3.5 41.4 1.0 N A:PHE514 3.5 38.8 1.0 N A:ILE515 3.6 40.9 1.0 CA A:GLY245 3.6 38.1 1.0 CB A:PHE514 3.6 38.8 1.0 N A:GLY248 3.6 38.6 1.0 H A:VAL513 3.7 39.5 1.0 CA A:GLY512 3.7 39.1 1.0 C A:GLY245 3.8 38.1 1.0 CG1 A:ILE515 3.8 40.9 1.0 N A:GLU247 3.8 41.4 1.0 N A:VAL513 3.8 39.5 1.0 C A:GLY512 3.8 39.1 1.0 HD2 A:PHE514 3.9 38.8 1.0 CB A:GLU247 3.9 41.4 1.0 CA A:PHE514 4.0 38.8 1.0 HB A:ILE515 4.0 40.9 1.0 O A:GLY245 4.0 38.1 1.0 CG A:GLU247 4.1 41.4 1.0 H A:GLY245 4.1 38.1 1.0 HA2 A:GLY512 4.2 39.1 1.0 HG13 A:ILE515 4.2 40.9 1.0 HD3 A:PRO516 4.2 39.5 1.0 HA3 A:GLY248 4.2 38.6 1.0 CA A:GLU247 4.2 41.4 1.0 N A:LYS246 4.2 40.7 1.0 HB3 A:PHE514 4.2 38.8 1.0 N A:GLY245 4.3 38.1 1.0 HG3 A:GLU247 4.3 41.4 1.0 HD3 A:PRO249 4.3 37.9 1.0 HD2 A:PRO516 4.3 39.5 1.0 C A:PHE514 4.3 38.8 1.0 CB A:ILE515 4.3 40.9 1.0 HD13 A:ILE515 4.3 40.9 1.0 HA2 A:GLY245 4.3 38.1 1.0 CD2 A:PHE514 4.4 38.8 1.0 CG A:PHE514 4.4 38.8 1.0 H A:LYS246 4.4 40.7 1.0 C A:GLU247 4.4 41.4 1.0 C A:VAL513 4.5 39.5 1.0 CL A:CL903 4.5 47.7 1.0 O A:GLY512 4.5 39.1 1.0 CA A:GLY248 4.5 38.6 1.0 CA A:ILE515 4.6 40.9 1.0 HD2 A:PRO249 4.6 37.9 1.0 CD1 A:ILE515 4.6 40.9 1.0 CA A:VAL513 4.7 39.5 1.0 HB3 A:GLU247 4.7 41.4 1.0 N A:GLY512 4.7 39.1 1.0 CD A:PRO516 4.7 39.5 1.0 C A:LYS246 4.9 40.7 1.0 H A:GLY512 4.9 39.1 1.0 CD A:PRO249 4.9 37.9 1.0 HA A:PHE514 4.9 38.8 1.0 HD11 A:ILE515 4.9 40.9 1.0 HA A:VAL513 5.0 39.5 1.0 HA2 A:GLY248 5.0 38.6 1.0

Chlorine binding site 3 out of 6 in the Structure of Human Clc-7/OSTM1 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of Human Clc-7/OSTM1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl905 b:35.8 occ:1.00 HA3 A:GLY203 2.8 39.2 1.0 HG2 A:PRO207 2.9 35.4 1.0 H A:SER204 3.0 38.0 1.0 H A:GLY205 3.1 36.9 1.0 HD2 A:PRO207 3.1 35.4 1.0 O A:HOH1013 3.4 37.5 1.0 HH A:TYR505 3.5 39.4 1.0 OH A:TYR505 3.5 39.4 1.0 N A:SER204 3.6 38.0 1.0 CA A:GLY203 3.7 39.2 1.0 CG A:PRO207 3.7 35.4 1.0 CD A:PRO207 3.7 35.4 1.0 OE1 A:GLN208 3.9 34.2 1.0 N A:GLY205 3.9 36.9 1.0 OG A:SER204 4.0 38.0 1.0 HA2 A:GLY203 4.0 39.2 1.0 HE22 A:GLN208 4.0 34.2 1.0 HD3 A:PRO207 4.0 35.4 1.0 C A:GLY203 4.0 39.2 1.0 O A:ALA202 4.2 39.7 1.0 HB2 A:PRO207 4.2 35.4 1.0 HG3 A:PRO207 4.3 35.4 1.0 CZ A:TYR505 4.4 39.4 1.0 HG A:SER204 4.4 38.0 1.0 HA2 A:GLY205 4.5 36.9 1.0 CB A:PRO207 4.5 35.4 1.0 CA A:SER204 4.6 38.0 1.0 NE2 A:GLN208 4.7 34.2 1.0 H A:ILE206 4.7 36.2 1.0 N A:GLY203 4.7 39.2 1.0 CD A:GLN208 4.7 34.2 1.0 CA A:GLY205 4.7 36.9 1.0 C A:SER204 4.8 38.0 1.0 HE1 A:TYR505 4.8 39.4 1.0 C A:ALA202 4.9 39.7 1.0 CB A:SER204 4.9 38.0 1.0 CE1 A:TYR505 5.0 39.4 1.0

Chlorine binding site 4 out of 6 in the Structure of Human Clc-7/OSTM1 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Structure of Human Clc-7/OSTM1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl903 b:46.6 occ:1.00 HH C:TYR602 2.3 36.8 1.0 H C:VAL513 2.4 39.3 1.0 HD12 C:ILE206 2.7 36.0 1.0 HG12 C:VAL513 2.7 39.3 1.0 OH C:TYR602 2.8 36.8 1.0 HB3 C:SER204 2.9 37.7 1.0 HB2 C:SER204 3.0 37.7 1.0 HG C:SER204 3.1 37.7 1.0 HA2 C:GLY512 3.2 39.0 1.0 N C:VAL513 3.2 39.3 1.0 HA3 C:GLY248 3.2 38.5 1.0 CB C:SER204 3.3 37.7 1.0 H C:PHE514 3.3 39.0 1.0 CD1 C:ILE206 3.5 36.0 1.0 HD11 C:ILE206 3.5 36.0 1.0 OG C:SER204 3.6 37.7 1.0 CG1 C:VAL513 3.7 39.3 1.0 HA3 C:GLY512 3.8 39.0 1.0 CA C:GLY512 3.8 39.0 1.0 HD13 C:ILE206 3.9 36.0 1.0 N C:PHE514 3.9 39.0 1.0 CD2 C:PHE514 3.9 39.0 1.0 C C:GLY512 4.0 39.0 1.0 CE2 C:PHE514 4.0 39.0 1.0 CZ C:TYR602 4.1 36.8 1.0 CG C:PHE514 4.1 39.0 1.0 HG13 C:VAL513 4.1 39.3 1.0 CA C:VAL513 4.1 39.3 1.0 HE1 C:TYR602 4.1 36.8 1.0 HD2 C:PHE514 4.2 39.0 1.0 CA C:GLY248 4.2 38.5 1.0 HG11 C:VAL513 4.2 39.3 1.0 CZ C:PHE514 4.3 39.0 1.0 HE2 C:PHE514 4.3 39.0 1.0 CD1 C:PHE514 4.3 39.0 1.0 CB C:VAL513 4.4 39.3 1.0 C C:VAL513 4.4 39.3 1.0 HA2 C:GLY248 4.4 38.5 1.0 HB C:VAL513 4.4 39.3 1.0 H C:GLY248 4.4 38.5 1.0 CE1 C:PHE514 4.4 39.0 1.0 CL C:CL904 4.5 43.0 1.0 HB2 C:PHE514 4.5 39.0 1.0 CE1 C:TYR602 4.5 36.8 1.0 HD3 C:PRO249 4.6 37.9 1.0 HB C:ILE206 4.7 36.0 1.0 CB C:PHE514 4.7 39.0 1.0 HE1 C:TYR505 4.7 39.1 1.0 CG1 C:ILE206 4.7 36.0 1.0 CA C:SER204 4.7 37.7 1.0 HZ C:PHE514 4.7 39.0 1.0 HG13 C:ILE206 4.8 36.0 1.0 N C:GLY248 4.8 38.5 1.0 HD1 C:PHE514 4.8 39.0 1.0 CA C:PHE514 4.9 39.0 1.0 HA C:SER204 4.9 37.7 1.0 HE1 C:PHE514 5.0 39.0 1.0 HA C:VAL513 5.0 39.3 1.0

Chlorine binding site 5 out of 6 in the Structure of Human Clc-7/OSTM1 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Structure of Human Clc-7/OSTM1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl904 b:43.0 occ:1.00 HB2 C:PHE514 2.7 39.0 1.0 H C:ILE515 2.8 41.0 1.0 H C:PHE514 2.8 39.0 1.0 H C:GLY248 2.8 38.5 1.0 HA3 C:GLY245 2.8 38.6 1.0 HG12 C:ILE515 2.8 41.0 1.0 HA3 C:GLY512 2.9 39.0 1.0 H C:GLU247 3.0 41.5 1.0 HB2 C:GLU247 3.1 41.5 1.0 HG2 C:GLU247 3.5 41.5 1.0 N C:PHE514 3.5 39.0 1.0 N C:ILE515 3.6 41.0 1.0 CA C:GLY245 3.6 38.6 1.0 CB C:PHE514 3.6 39.0 1.0 N C:GLY248 3.6 38.5 1.0 H C:VAL513 3.7 39.3 1.0 CA C:GLY512 3.7 39.0 1.0 C C:GLY245 3.8 38.6 1.0 CG1 C:ILE515 3.8 41.0 1.0 N C:GLU247 3.8 41.5 1.0 N C:VAL513 3.8 39.3 1.0 C C:GLY512 3.8 39.0 1.0 HD2 C:PHE514 3.9 39.0 1.0 CB C:GLU247 3.9 41.5 1.0 CA C:PHE514 4.0 39.0 1.0 HB C:ILE515 4.0 41.0 1.0 O C:GLY245 4.0 38.6 1.0 CG C:GLU247 4.1 41.5 1.0 H C:GLY245 4.1 38.6 1.0 HA2 C:GLY512 4.2 39.0 1.0 HG13 C:ILE515 4.2 41.0 1.0 HD3 C:PRO516 4.2 39.5 1.0 HA3 C:GLY248 4.2 38.5 1.0 CA C:GLU247 4.2 41.5 1.0 N C:LYS246 4.2 40.9 1.0 HB3 C:PHE514 4.2 39.0 1.0 N C:GLY245 4.3 38.6 1.0 HG3 C:GLU247 4.3 41.5 1.0 HD3 C:PRO249 4.3 37.9 1.0 HD2 C:PRO516 4.3 39.5 1.0 C C:PHE514 4.3 39.0 1.0 HD13 C:ILE515 4.3 41.0 1.0 CB C:ILE515 4.3 41.0 1.0 HA2 C:GLY245 4.3 38.6 1.0 CD2 C:PHE514 4.4 39.0 1.0 CG C:PHE514 4.4 39.0 1.0 H C:LYS246 4.4 40.9 1.0 C C:GLU247 4.4 41.5 1.0 C C:VAL513 4.5 39.3 1.0 CL C:CL903 4.5 46.6 1.0 O C:GLY512 4.5 39.0 1.0 CA C:GLY248 4.5 38.5 1.0 CA C:ILE515 4.6 41.0 1.0 HD2 C:PRO249 4.6 37.9 1.0 CD1 C:ILE515 4.6 41.0 1.0 CA C:VAL513 4.7 39.3 1.0 HB3 C:GLU247 4.7 41.5 1.0 N C:GLY512 4.7 39.0 1.0 CD C:PRO516 4.7 39.5 1.0 C C:LYS246 4.9 40.9 1.0 H C:GLY512 4.9 39.0 1.0 CD C:PRO249 4.9 37.9 1.0 HA C:PHE514 4.9 39.0 1.0 HD11 C:ILE515 4.9 41.0 1.0 HA C:VAL513 5.0 39.3 1.0 HA2 C:GLY248 5.0 38.5 1.0

Chlorine binding site 6 out of 6 in the Structure of Human Clc-7/OSTM1 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Structure of Human Clc-7/OSTM1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl905 b:35.9 occ:1.00 HA3 C:GLY203 2.8 38.7 1.0 HG2 C:PRO207 2.9 35.1 1.0 H C:SER204 3.0 37.7 1.0 H C:GLY205 3.1 36.5 1.0 HD2 C:PRO207 3.1 35.1 1.0 O C:HOH1013 3.4 34.9 1.0 HH C:TYR505 3.5 39.1 1.0 OH C:TYR505 3.5 39.1 1.0 N C:SER204 3.6 37.7 1.0 CA C:GLY203 3.7 38.7 1.0 CG C:PRO207 3.7 35.1 1.0 CD C:PRO207 3.7 35.1 1.0 OE1 C:GLN208 3.9 34.1 1.0 N C:GLY205 3.9 36.5 1.0 OG C:SER204 4.0 37.7 1.0 HA2 C:GLY203 4.0 38.7 1.0 HE22 C:GLN208 4.0 34.1 1.0 HD3 C:PRO207 4.0 35.1 1.0 C C:GLY203 4.0 38.7 1.0 O C:ALA202 4.2 39.4 1.0 HB2 C:PRO207 4.2 35.1 1.0 HG3 C:PRO207 4.3 35.1 1.0 CZ C:TYR505 4.4 39.1 1.0 HG C:SER204 4.4 37.7 1.0 HA2 C:GLY205 4.5 36.5 1.0 CB C:PRO207 4.5 35.1 1.0 CA C:SER204 4.6 37.7 1.0 NE2 C:GLN208 4.7 34.1 1.0 H C:ILE206 4.7 36.0 1.0 N C:GLY203 4.7 38.7 1.0 CD C:GLN208 4.7 34.1 1.0 CA C:GLY205 4.7 36.5 1.0 C C:SER204 4.8 37.7 1.0 HE1 C:TYR505 4.8 39.1 1.0 C C:ALA202 4.9 39.4 1.0 CB C:SER204 4.9 37.7 1.0 CE1 C:TYR505 5.0 39.1 1.0

M.Schrecker, J.Korobenko, R.K.Hite. Cryo-Em Structure of the Lysosomal Chloride-Proton Exchanger Clc-7 in Complex with OSTM1. Elife V. 9 2020.
ISSN: ESSN 2050-084X
PubMed: 32749217
DOI: 10.7554/ELIFE.59555