Chlorine in PDB 7km9: Crystal Structure of Dihydrofolate Reductase (Dhfr) From Mycobacterium Ulcerans AGY99 in Complex with Nadp and Inhibitor Sddc-0001913, Tetragonal Crystal From

Enzymatic activity of Crystal Structure of Dihydrofolate Reductase (Dhfr) From Mycobacterium Ulcerans AGY99 in Complex with Nadp and Inhibitor Sddc-0001913, Tetragonal Crystal From

All present enzymatic activity of Crystal Structure of Dihydrofolate Reductase (Dhfr) From Mycobacterium Ulcerans AGY99 in Complex with Nadp and Inhibitor Sddc-0001913, Tetragonal Crystal From:
1.5.1.3;

Protein crystallography data

The structure of Crystal Structure of Dihydrofolate Reductase (Dhfr) From Mycobacterium Ulcerans AGY99 in Complex with Nadp and Inhibitor Sddc-0001913, Tetragonal Crystal From, PDB code: 7km9 was solved by Seattle Structural Genomics Center For Infectious Disease (Ssgcid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.73 / 1.95
Space group P 41 2 2
Cell size a, b, c (Å), α, β, γ (°) 58.97, 58.97, 130.34, 90, 90, 90
R / Rfree (%) 18.2 / 21.3

Other elements in 7km9:

The structure of Crystal Structure of Dihydrofolate Reductase (Dhfr) From Mycobacterium Ulcerans AGY99 in Complex with Nadp and Inhibitor Sddc-0001913, Tetragonal Crystal From also contains other interesting chemical elements:

Fluorine (F) 2 atoms
Bromine (Br) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Dihydrofolate Reductase (Dhfr) From Mycobacterium Ulcerans AGY99 in Complex with Nadp and Inhibitor Sddc-0001913, Tetragonal Crystal From (pdb code 7km9). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Dihydrofolate Reductase (Dhfr) From Mycobacterium Ulcerans AGY99 in Complex with Nadp and Inhibitor Sddc-0001913, Tetragonal Crystal From, PDB code: 7km9:

Chlorine binding site 1 out of 1 in 7km9

Go back to Chlorine Binding Sites List in 7km9
Chlorine binding site 1 out of 1 in the Crystal Structure of Dihydrofolate Reductase (Dhfr) From Mycobacterium Ulcerans AGY99 in Complex with Nadp and Inhibitor Sddc-0001913, Tetragonal Crystal From


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Dihydrofolate Reductase (Dhfr) From Mycobacterium Ulcerans AGY99 in Complex with Nadp and Inhibitor Sddc-0001913, Tetragonal Crystal From within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl205

b:65.0
occ:1.00
 OH A:TYR162 3.3 44.0 1.0
O A:HOH368 3.9 46.1 1.0
O A:HOH319 4.0 47.4 1.0
OE1 A:GLN10 4.2 33.1 1.0
CD2 A:HIS160 4.2 33.5 1.0
NE2 A:GLN10 4.3 34.9 1.0
CZ A:TYR162 4.3 45.5 1.0
CD A:GLN10 4.3 32.7 1.0
CG1 A:VAL118 4.4 29.3 1.0
NE2 A:HIS160 4.4 36.1 1.0
O A:HOH333 4.6 48.8 1.0
CE2 A:TYR162 4.6 38.3 1.0
CG A:HIS160 4.8 40.6 1.0
O A:HOH393 4.8 51.9 1.0
OE1 A:GLU120 4.9 35.3 1.0
CE1 A:HIS160 5.0 41.2 1.0

Reference:

J.Abendroth, D.M.Dranow, D.D.Lorimer, P.S.Horanyi, T.E.Edwards. Crystal Structure of Dihydrofolate Reductase (Dhfr) From Mycobacterium Ulcerans AGY99 in Complex with Nadp and Inhibitor Sddc-0001913, Tetragonal Crystal Form To Be Published.
Page generated: Mon Jul 29 23:38:55 2024

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