Chlorine in PDB 7koq: Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State

The structure of Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State also contains other interesting chemical elements:

Calcium

(Ca)

5 atoms

The binding sites of Chlorine atom in the Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State (pdb code 7koq). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State, PDB code: 7koq:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in the Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl503 b:39.6 occ:1.00 CL A:EPJ503 0.0 39.6 1.0 C10 A:EPJ503 1.7 39.6 1.0 HB2 B:LEU108 2.5 40.6 1.0 N2 A:EPJ503 2.6 39.6 1.0 C9 A:EPJ503 2.7 39.6 1.0 H9 A:EPJ503 2.8 39.6 1.0 HB3 B:LEU108 3.3 40.6 1.0 CB B:LEU108 3.3 40.6 1.0 HD22 B:LEU108 3.4 40.6 1.0 H B:LEU108 3.7 40.6 1.0 HB2 B:GLN116 3.8 39.9 1.0 C11 A:EPJ503 3.9 39.6 1.0 HD13 B:LEU108 3.9 40.6 1.0 HA A:SER149 3.9 39.2 1.0 C8 A:EPJ503 4.0 39.6 1.0 HD13 B:LEU118 4.0 36.0 1.0 HB3 A:SER149 4.0 39.2 1.0 N B:LEU108 4.1 40.6 1.0 CD2 B:LEU108 4.1 40.6 1.0 HB2 A:SER149 4.2 39.2 1.0 CG B:LEU108 4.2 40.6 1.0 HB3 B:GLN116 4.3 39.9 1.0 CA B:LEU108 4.3 40.6 1.0 HD23 B:LEU108 4.4 40.6 1.0 OE1 B:GLN116 4.4 39.9 1.0 C7 A:EPJ503 4.4 39.6 1.0 CB A:SER149 4.4 39.2 1.0 O B:GLN116 4.5 39.9 1.0 CB B:GLN116 4.5 39.9 1.0 CD1 B:LEU108 4.5 40.6 1.0 HA B:VAL107 4.6 38.5 1.0 H11 A:EPJ503 4.6 39.6 1.0 CA A:SER149 4.7 39.2 1.0 H8 A:EPJ503 4.7 39.6 1.0 H B:LEU118 4.7 36.0 1.0 HA B:LEU108 4.8 40.6 1.0 CD1 B:LEU118 4.8 36.0 1.0 C B:VAL107 4.8 38.5 1.0 HD12 B:LEU108 4.9 40.6 1.0 HD12 B:LEU118 4.9 36.0 1.0 C B:GLN116 4.9 39.9 1.0 HB2 B:LEU118 4.9 36.0 1.0 HA B:TYR117 4.9 37.1 1.0 HD21 B:LEU108 5.0 40.6 1.0

Chlorine binding site 2 out of 5 in the Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl503 b:40.0 occ:1.00 CL B:EPJ503 0.0 40.0 1.0 C10 B:EPJ503 1.7 40.0 1.0 HB2 C:LEU108 2.5 42.0 1.0 N2 B:EPJ503 2.6 40.0 1.0 C9 B:EPJ503 2.7 40.0 1.0 H9 B:EPJ503 2.8 40.0 1.0 HB3 C:LEU108 3.2 42.0 1.0 CB C:LEU108 3.3 42.0 1.0 HD22 C:LEU108 3.5 42.0 1.0 H C:LEU108 3.6 42.0 1.0 HB2 C:GLN116 3.8 40.8 1.0 C11 B:EPJ503 3.9 40.0 1.0 HA B:SER149 3.9 40.2 1.0 HD13 C:LEU118 4.0 37.0 1.0 C8 B:EPJ503 4.0 40.0 1.0 HD13 C:LEU108 4.0 42.0 1.0 N C:LEU108 4.0 42.0 1.0 HB3 B:SER149 4.0 40.2 1.0 HB2 B:SER149 4.2 40.2 1.0 CD2 C:LEU108 4.2 42.0 1.0 CG C:LEU108 4.2 42.0 1.0 HB3 C:GLN116 4.2 40.8 1.0 CA C:LEU108 4.3 42.0 1.0 O C:GLN116 4.4 40.8 1.0 HA C:VAL107 4.4 39.3 1.0 HD23 C:LEU108 4.4 42.0 1.0 C7 B:EPJ503 4.4 40.0 1.0 CB B:SER149 4.4 40.2 1.0 CB C:GLN116 4.5 40.8 1.0 OE1 C:GLN116 4.5 40.8 1.0 CD1 C:LEU108 4.6 42.0 1.0 H C:LEU118 4.6 37.0 1.0 H11 B:EPJ503 4.6 40.0 1.0 CA B:SER149 4.7 40.2 1.0 H8 B:EPJ503 4.7 40.0 1.0 C C:VAL107 4.7 39.3 1.0 HA C:LEU108 4.7 42.0 1.0 C C:GLN116 4.8 40.8 1.0 HA C:TYR117 4.8 37.5 1.0 CD1 C:LEU118 4.8 37.0 1.0 HD12 C:LEU118 4.8 37.0 1.0 HB2 C:LEU118 4.9 37.0 1.0 HD12 C:LEU108 4.9 42.0 1.0

Chlorine binding site 3 out of 5 in the Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl503 b:39.9 occ:1.00 CL C:EPJ503 0.0 39.9 1.0 C10 C:EPJ503 1.7 39.9 1.0 HB2 D:LEU108 2.5 41.9 1.0 N2 C:EPJ503 2.6 39.9 1.0 C9 C:EPJ503 2.7 39.9 1.0 H9 C:EPJ503 2.8 39.9 1.0 HB3 D:LEU108 3.2 41.9 1.0 CB D:LEU108 3.3 41.9 1.0 HD22 D:LEU108 3.3 41.9 1.0 HB2 D:GLN116 3.8 40.5 1.0 H D:LEU108 3.8 41.9 1.0 HD13 D:LEU108 3.9 41.9 1.0 C11 C:EPJ503 3.9 39.9 1.0 HD13 D:LEU118 3.9 36.6 1.0 HA C:SER149 3.9 39.7 1.0 C8 C:EPJ503 4.0 39.9 1.0 HB3 C:SER149 4.0 39.7 1.0 CD2 D:LEU108 4.0 41.9 1.0 CG D:LEU108 4.1 41.9 1.0 N D:LEU108 4.1 41.9 1.0 HB2 C:SER149 4.2 39.7 1.0 HB3 D:GLN116 4.2 40.5 1.0 HD23 D:LEU108 4.3 41.9 1.0 OE1 D:GLN116 4.3 40.5 1.0 CA D:LEU108 4.3 41.9 1.0 CB D:GLN116 4.4 40.5 1.0 C7 C:EPJ503 4.4 39.9 1.0 CB C:SER149 4.4 39.7 1.0 CD1 D:LEU108 4.5 41.9 1.0 O D:GLN116 4.5 40.5 1.0 H11 C:EPJ503 4.6 39.9 1.0 HA D:VAL107 4.7 39.5 1.0 CA C:SER149 4.7 39.7 1.0 H8 C:EPJ503 4.7 39.9 1.0 H D:LEU118 4.8 36.6 1.0 CD1 D:LEU118 4.8 36.6 1.0 HA D:LEU108 4.8 41.9 1.0 HD21 D:LEU108 4.8 41.9 1.0 HD12 D:LEU108 4.9 41.9 1.0 C D:GLN116 4.9 40.5 1.0 HD12 D:LEU118 4.9 36.6 1.0 C D:VAL107 4.9 39.5 1.0 HB2 D:LEU118 4.9 36.6 1.0 HA D:TYR117 5.0 37.1 1.0 HG D:LEU108 5.0 41.9 1.0

Chlorine binding site 4 out of 5 in the Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl503 b:40.5 occ:1.00 CL D:EPJ503 0.0 40.5 1.0 C10 D:EPJ503 1.7 40.5 1.0 HB2 E:LEU108 2.5 41.8 1.0 N2 D:EPJ503 2.6 40.5 1.0 C9 D:EPJ503 2.7 40.5 1.0 H9 D:EPJ503 2.8 40.5 1.0 HB3 E:LEU108 3.2 41.8 1.0 HD22 E:LEU108 3.2 41.8 1.0 CB E:LEU108 3.2 41.8 1.0 HB2 E:GLN116 3.7 40.2 1.0 H E:LEU108 3.8 41.8 1.0 HD13 E:LEU108 3.8 41.8 1.0 C11 D:EPJ503 3.9 40.5 1.0 HA D:SER149 3.9 40.9 1.0 HD13 E:LEU118 3.9 36.2 1.0 CD2 E:LEU108 3.9 41.8 1.0 C8 D:EPJ503 4.0 40.5 1.0 HB3 D:SER149 4.0 40.9 1.0 CG E:LEU108 4.1 41.8 1.0 N E:LEU108 4.2 41.8 1.0 HB2 D:SER149 4.2 40.9 1.0 HD23 E:LEU108 4.2 41.8 1.0 HB3 E:GLN116 4.2 40.2 1.0 OE1 E:GLN116 4.2 40.2 1.0 CA E:LEU108 4.3 41.8 1.0 CB E:GLN116 4.4 40.2 1.0 C7 D:EPJ503 4.4 40.5 1.0 CB D:SER149 4.4 40.9 1.0 CD1 E:LEU108 4.5 41.8 1.0 O E:GLN116 4.6 40.2 1.0 H11 D:EPJ503 4.6 40.5 1.0 CA D:SER149 4.7 40.9 1.0 H8 D:EPJ503 4.7 40.5 1.0 HA E:VAL107 4.7 39.6 1.0 HD21 E:LEU108 4.8 41.8 1.0 HA E:LEU108 4.8 41.8 1.0 CD1 E:LEU118 4.8 36.2 1.0 HD12 E:LEU108 4.8 41.8 1.0 H E:LEU118 4.8 36.2 1.0 C E:GLN116 4.9 40.2 1.0 HD12 E:LEU118 4.9 36.2 1.0 HG E:LEU108 4.9 41.8 1.0 C E:VAL107 5.0 39.6 1.0 HB2 E:LEU118 5.0 36.2 1.0

Chlorine binding site 5 out of 5 in the Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Alpha-7 Nicotinic Acetylcholine Receptor Bound to Epibatidine in A Desensitized State within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl503 b:40.2 occ:1.00 CL E:EPJ503 0.0 40.2 1.0 C10 E:EPJ503 1.7 40.2 1.0 HB2 A:LEU108 2.5 40.9 1.0 N2 E:EPJ503 2.6 40.2 1.0 C9 E:EPJ503 2.7 40.2 1.0 H9 E:EPJ503 2.8 40.2 1.0 HB3 A:LEU108 3.2 40.9 1.0 CB A:LEU108 3.3 40.9 1.0 HD22 A:LEU108 3.3 40.9 1.0 H A:LEU108 3.8 40.9 1.0 HB2 A:GLN116 3.8 39.8 1.0 HD13 A:LEU108 3.8 40.9 1.0 C11 E:EPJ503 3.9 40.2 1.0 HA E:SER149 3.9 38.8 1.0 C8 E:EPJ503 4.0 40.2 1.0 HD13 A:LEU118 4.0 36.4 1.0 CD2 A:LEU108 4.0 40.9 1.0 HB3 E:SER149 4.0 38.8 1.0 CG A:LEU108 4.1 40.9 1.0 N A:LEU108 4.1 40.9 1.0 HB2 E:SER149 4.2 38.8 1.0 HD23 A:LEU108 4.2 40.9 1.0 HB3 A:GLN116 4.3 39.8 1.0 CA A:LEU108 4.3 40.9 1.0 OE1 A:GLN116 4.3 39.8 1.0 C7 E:EPJ503 4.4 40.2 1.0 CB E:SER149 4.4 38.8 1.0 CD1 A:LEU108 4.4 40.9 1.0 CB A:GLN116 4.5 39.8 1.0 O A:GLN116 4.6 39.8 1.0 H11 E:EPJ503 4.6 40.2 1.0 CA E:SER149 4.7 38.8 1.0 HA A:VAL107 4.7 38.5 1.0 H8 E:EPJ503 4.7 40.2 1.0 HA A:LEU108 4.8 40.9 1.0 HD12 A:LEU108 4.8 40.9 1.0 HD21 A:LEU108 4.8 40.9 1.0 H A:LEU118 4.8 36.4 1.0 CD1 A:LEU118 4.8 36.4 1.0 C A:VAL107 4.9 38.5 1.0 C A:GLN116 4.9 39.8 1.0 HD12 A:LEU118 5.0 36.4 1.0 HG A:LEU108 5.0 40.9 1.0 HB2 A:LEU118 5.0 36.4 1.0

C.M.Noviello, R.E.Hibbs. Structure and Gating Mechanism of the Alpha-7 Nicotinic Acetylcholine Receptor Cell(Cambridge,Mass.) 2021.
ISSN: ISSN 0092-8674
DOI: 10.1016/J.CELL.2021.02.049