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Chlorine in PDB 7kth: Dna Polymerase Mu, 8-Oxodgtp:Ct Product State Ternary Complex, 10 Mm MG2+ (2160MIN)

Enzymatic activity of Dna Polymerase Mu, 8-Oxodgtp:Ct Product State Ternary Complex, 10 Mm MG2+ (2160MIN)

All present enzymatic activity of Dna Polymerase Mu, 8-Oxodgtp:Ct Product State Ternary Complex, 10 Mm MG2+ (2160MIN):
2.7.7.7;

Protein crystallography data

The structure of Dna Polymerase Mu, 8-Oxodgtp:Ct Product State Ternary Complex, 10 Mm MG2+ (2160MIN), PDB code: 7kth was solved by J.A.Jamsen, S.H.Wilson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 41.82 / 1.48
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 60.089, 68.373, 111.095, 90, 90, 90
R / Rfree (%) 16.6 / 19

Other elements in 7kth:

The structure of Dna Polymerase Mu, 8-Oxodgtp:Ct Product State Ternary Complex, 10 Mm MG2+ (2160MIN) also contains other interesting chemical elements:

Magnesium (Mg) 1 atom
Sodium (Na) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Dna Polymerase Mu, 8-Oxodgtp:Ct Product State Ternary Complex, 10 Mm MG2+ (2160MIN) (pdb code 7kth). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Dna Polymerase Mu, 8-Oxodgtp:Ct Product State Ternary Complex, 10 Mm MG2+ (2160MIN), PDB code: 7kth:

Chlorine binding site 1 out of 1 in 7kth

Go back to Chlorine Binding Sites List in 7kth
Chlorine binding site 1 out of 1 in the Dna Polymerase Mu, 8-Oxodgtp:Ct Product State Ternary Complex, 10 Mm MG2+ (2160MIN)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Dna Polymerase Mu, 8-Oxodgtp:Ct Product State Ternary Complex, 10 Mm MG2+ (2160MIN) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl512

b:43.2
occ:0.81
 OG A:SER172 1.8 29.1 0.5
O A:HOH775 2.7 35.2 1.0
CB A:SER172 3.0 26.9 0.5
CB A:SER172 3.2 27.9 0.5
N A:ARG175 3.3 17.1 0.6
N A:ARG175 3.3 17.1 0.4
CA A:SER172 3.3 23.3 0.5
C A:SER172 3.3 21.0 0.5
CA A:SER172 3.3 23.3 0.5
N A:GLY174 3.3 19.8 1.0
C A:SER172 3.4 21.1 0.5
O A:SER172 3.6 22.1 0.5
NH1 A:ARG175 3.6 31.1 0.6
CG A:ARG175 3.6 21.9 0.6
CA A:GLY174 3.7 19.1 1.0
CG A:ARG175 3.8 22.1 0.4
N A:GLU173 3.8 21.6 1.0
O A:SER172 3.9 20.4 0.5
C A:GLY174 4.0 16.0 1.0
CB A:ARG175 4.1 20.2 0.6
CB A:ARG175 4.1 20.2 0.4
CD A:ARG175 4.1 22.7 0.6
O6 D:DG1 4.2 19.5 1.0
CA A:ARG175 4.3 17.1 0.6
OG A:SER172 4.3 29.5 0.5
C A:GLU173 4.3 17.4 1.0
CA A:ARG175 4.3 17.1 0.4
CD A:ARG175 4.4 24.8 0.4
O D:HOH114 4.4 25.2 0.4
C6 D:DG1 4.6 19.7 1.0
CA A:GLU173 4.6 18.6 1.0
CZ A:ARG175 4.7 36.1 0.6
N A:SER172 4.7 23.4 0.5
N A:SER172 4.7 23.3 0.5
O A:HOH792 4.8 41.2 1.0
NE A:ARG175 4.8 29.2 0.4
C5 D:DG1 4.8 17.1 1.0
NE A:ARG175 4.9 30.7 0.6
N7 D:DG1 4.9 21.2 1.0

Reference:

J.A.Jamsen, A.Sassa, D.D.Shock, W.A.Beard, S.H.Wilson. Watching A Double Strand Break Repair Polymerase Insert A Pro-Mutagenic Oxidized Nucleotide. Nat Commun V. 12 2059 2021.
ISSN: ESSN 2041-1723
PubMed: 33824325
DOI: 10.1038/S41467-021-21354-6
Page generated: Mon Jul 29 23:45:40 2024

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