Chlorine in PDB 7kxz: Active Conformation of Egfr Kinase in Complex with Bi-4020

All present enzymatic activity of Active Conformation of Egfr Kinase in Complex with Bi-4020:
2.7.10.1;

The structure of Active Conformation of Egfr Kinase in Complex with Bi-4020, PDB code: 7kxz was solved by T.S.Beyett, M.J.Eck, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	51.37 / 2.40
Space group	I 2 3
Cell size a, b, c (Å), α, β, γ (°)	145.293, 145.293, 145.293, 90, 90, 90
R / Rfree (%)	19 / 21.9

The binding sites of Chlorine atom in the Active Conformation of Egfr Kinase in Complex with Bi-4020 (pdb code 7kxz). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Active Conformation of Egfr Kinase in Complex with Bi-4020, PDB code: 7kxz:

Chlorine binding site 1 out of 1 in the Active Conformation of Egfr Kinase in Complex with Bi-4020


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Active Conformation of Egfr Kinase in Complex with Bi-4020 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1101 b:83.0 occ:1.00 N A:ILE878 3.5 69.0 1.0 N A:LYS879 3.6 65.7 1.0 CG A:LYS879 3.9 61.5 1.0 C A:PRO877 4.0 69.2 1.0 CB A:LYS879 4.1 63.8 1.0 CA A:PRO877 4.1 74.7 1.0 CZ3 A:TRP880 4.2 55.9 1.0 CA A:ILE878 4.3 69.9 1.0 CD A:LYS879 4.4 69.6 1.0 CB A:ILE878 4.4 72.0 1.0 C A:ILE878 4.5 69.1 1.0 CA A:LYS879 4.5 64.3 1.0 CE3 A:TRP880 4.5 57.6 1.0 CB A:PRO877 4.7 72.2 1.0 O A:PRO877 4.8 70.6 1.0 CE A:LYS879 4.9 76.2 1.0 CG1 A:ILE878 4.9 74.6 1.0 O A:VAL876 5.0 85.4 1.0

T.S.Beyett, D.E.Heppner, J.Rana, M.J.Eck. Structural Analysis of the Macrocyclic Inhibitor Bi-4020 Binding to the Active and Inactive Conformations of Egfr Kinase To Be Published.