Chlorine in PDB 7l5t: Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid

Enzymatic activity of Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid

All present enzymatic activity of Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid:
3.5.2.6;

Protein crystallography data

The structure of Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid, PDB code: 7l5t was solved by G.Minasov, L.Shuvalova, M.Rosas-Lemus, J.S.Brunzelle, K.J.F.Satchell, Center For Structural Genomics Of Infectious Diseases (Csgid), Centerfor Membrane Proteins Of Infectious Diseases (Mpid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.91 / 1.88
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 48.94, 95.451, 125.974, 90, 90, 90
R / Rfree (%) 16.7 / 19.6

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid (pdb code 7l5t). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid, PDB code: 7l5t:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 7l5t

Go back to Chlorine Binding Sites List in 7l5t
Chlorine binding site 1 out of 4 in the Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl311

b:33.5
occ:0.60
 CL A:CL311 0.0 33.5 0.6
CL A:CL311 2.0 43.0 0.4
OG1 A:THR206 2.9 18.7 1.0
OG A:SER115 3.1 21.4 1.0
CAG A:ISS301 3.5 25.6 1.0
O A:THR206 3.5 15.8 1.0
OAH A:ISS301 3.5 20.1 1.0
C A:THR206 3.6 16.4 1.0
NH1 A:ARG250 3.7 28.9 1.0
N A:GLY207 3.7 15.8 1.0
CB A:THR206 3.7 19.3 1.0
CA A:GLY207 3.7 15.8 1.0
CB A:SER67 3.8 16.6 1.0
CB A:SER115 3.9 19.2 1.0
OG A:SER67 3.9 19.9 1.0
O A:HOH534 4.0 35.4 1.0
O2 A:SO4307 4.0 29.3 0.3
NZ A:LYS205 4.1 17.1 1.0
NH2 A:ARG250 4.1 29.3 1.0
CAI A:ISS301 4.1 32.4 1.0
C A:GLY207 4.2 17.2 1.0
CZ A:ARG250 4.3 28.8 1.0
CA A:THR206 4.3 17.1 1.0
N A:PHE208 4.4 18.1 1.0
CAJ A:ISS301 4.7 34.2 1.0
O A:GLY207 4.9 18.5 1.0
CB A:PHE208 5.0 21.4 1.0

Chlorine binding site 2 out of 4 in 7l5t

Go back to Chlorine Binding Sites List in 7l5t
Chlorine binding site 2 out of 4 in the Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl311

b:43.0
occ:0.40
 CL A:CL311 0.0 43.0 0.4
CL A:CL311 2.0 33.5 0.6
NH1 A:ARG250 2.9 28.9 1.0
NH2 A:ARG250 3.3 29.3 1.0
CZ A:ARG250 3.6 28.8 1.0
CB A:PHE208 3.7 21.4 1.0
OAH A:ISS301 4.1 20.1 1.0
CAG A:ISS301 4.2 25.6 1.0
OG1 A:THR206 4.2 18.7 1.0
N A:PHE208 4.2 18.1 1.0
CAI A:ISS301 4.3 32.4 1.0
C A:GLY207 4.3 17.2 1.0
CAJ A:ISS301 4.4 34.2 1.0
O2 A:SO4307 4.4 29.3 0.3
CA A:GLY207 4.6 15.8 1.0
CA A:PHE208 4.6 19.8 1.0
OG A:SER115 4.7 21.4 1.0
N A:GLY207 4.7 15.8 1.0
CB A:THR206 4.7 19.3 1.0
CG A:PHE208 4.8 24.6 1.0
O A:GLY207 4.8 18.5 1.0
CD2 A:PHE208 4.8 28.5 1.0
O A:HOH534 4.8 35.4 1.0
NE A:ARG250 4.9 25.6 1.0
C A:THR206 5.0 16.4 1.0

Chlorine binding site 3 out of 4 in 7l5t

Go back to Chlorine Binding Sites List in 7l5t
Chlorine binding site 3 out of 4 in the Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl308

b:52.1
occ:0.60
 CL B:CL308 0.0 52.1 0.6
CL B:CL308 1.4 52.1 0.4
OG B:SER115 3.0 36.2 1.0
OG1 B:THR206 3.0 28.2 1.0
O B:THR206 3.6 26.3 1.0
OAH B:ISS301 3.6 33.7 1.0
C B:THR206 3.7 26.7 1.0
OG B:SER67 3.7 36.6 1.0
CB B:SER115 3.7 39.2 1.0
CB B:SER67 3.8 31.8 1.0
NH1 B:ARG250 3.8 43.0 1.0
CB B:THR206 3.9 27.3 1.0
N B:GLY207 3.9 28.4 1.0
CA B:GLY207 4.0 30.0 1.0
CAG B:ISS301 4.0 40.0 1.0
NZ B:LYS205 4.2 26.8 1.0
O B:HOH415 4.2 48.2 1.0
NH2 B:ARG250 4.4 44.4 1.0
CA B:THR206 4.4 26.1 1.0
C B:GLY207 4.4 31.3 1.0
N B:PHE208 4.5 33.2 1.0
CZ B:ARG250 4.5 41.5 1.0
CAI B:ISS301 4.5 53.5 1.0
CAJ B:ISS301 4.6 59.0 1.0

Chlorine binding site 4 out of 4 in 7l5t

Go back to Chlorine Binding Sites List in 7l5t
Chlorine binding site 4 out of 4 in the Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl308

b:52.1
occ:0.40
 CL B:CL308 0.0 52.1 0.4
CL B:CL308 1.4 52.1 0.6
NH1 B:ARG250 2.9 43.0 1.0
NH2 B:ARG250 3.6 44.4 1.0
OAH B:ISS301 3.7 33.7 1.0
CZ B:ARG250 3.7 41.5 1.0
OG1 B:THR206 3.7 28.2 1.0
N B:PHE208 3.8 33.2 1.0
CB B:PHE208 3.9 37.8 1.0
C B:GLY207 4.0 31.3 1.0
CA B:GLY207 4.0 30.0 1.0
N B:GLY207 4.1 28.4 1.0
CB B:THR206 4.2 27.3 1.0
C B:THR206 4.3 26.7 1.0
OG B:SER115 4.3 36.2 1.0
CAG B:ISS301 4.3 40.0 1.0
CAJ B:ISS301 4.3 59.0 1.0
O B:THR206 4.4 26.3 1.0
OG B:SER67 4.4 36.6 1.0
O B:HOH415 4.5 48.2 1.0
CA B:PHE208 4.5 35.9 1.0
O B:GLY207 4.6 30.9 1.0
CAI B:ISS301 4.6 53.5 1.0
CB B:SER67 4.7 31.8 1.0
CB B:SER115 4.8 39.2 1.0
CA B:THR206 4.9 26.1 1.0
NE B:ARG250 5.0 39.3 1.0

Reference:

G.Minasov, L.Shuvalova, M.Rosas-Lemus, J.S.Brunzelle, K.J.F.Satchell, Center For Structural Genomics Of Infectious Diseases(Csgid). Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended-Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid To Be Published.
Page generated: Mon Jul 29 23:52:53 2024

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