Chlorine in PDB 7l5t: Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid

Enzymatic activity of Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid

All present enzymatic activity of Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid:
3.5.2.6;

Protein crystallography data

The structure of Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid, PDB code: 7l5t was solved by G.Minasov, L.Shuvalova, M.Rosas-Lemus, J.S.Brunzelle, K.J.F.Satchell, Center For Structural Genomics Of Infectious Diseases (Csgid), Centerfor Membrane Proteins Of Infectious Diseases (Mpid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.91 / 1.88
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 48.94, 95.451, 125.974, 90, 90, 90
R / Rfree (%) 16.7 / 19.6

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid (pdb code 7l5t). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid, PDB code: 7l5t:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 7l5t

Go back to Chlorine Binding Sites List in 7l5t
Chlorine binding site 1 out of 4 in the Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl311

b:33.5
occ:0.60
 CL A:CL311 0.0 33.5 0.6
CL A:CL311 2.0 43.0 0.4
OG1 A:THR206 2.9 18.7 1.0
OG A:SER115 3.1 21.4 1.0
CAG A:ISS301 3.5 25.6 1.0
O A:THR206 3.5 15.8 1.0
OAH A:ISS301 3.5 20.1 1.0
C A:THR206 3.6 16.4 1.0
NH1 A:ARG250 3.7 28.9 1.0
N A:GLY207 3.7 15.8 1.0
CB A:THR206 3.7 19.3 1.0
CA A:GLY207 3.7 15.8 1.0
CB A:SER67 3.8 16.6 1.0
CB A:SER115 3.9 19.2 1.0
OG A:SER67 3.9 19.9 1.0
O A:HOH534 4.0 35.4 1.0
O2 A:SO4307 4.0 29.3 0.3
NZ A:LYS205 4.1 17.1 1.0
NH2 A:ARG250 4.1 29.3 1.0
CAI A:ISS301 4.1 32.4 1.0
C A:GLY207 4.2 17.2 1.0
CZ A:ARG250 4.3 28.8 1.0
CA A:THR206 4.3 17.1 1.0
N A:PHE208 4.4 18.1 1.0
CAJ A:ISS301 4.7 34.2 1.0
O A:GLY207 4.9 18.5 1.0
CB A:PHE208 5.0 21.4 1.0

Chlorine binding site 2 out of 4 in 7l5t

Go back to Chlorine Binding Sites List in 7l5t
Chlorine binding site 2 out of 4 in the Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl311

b:43.0
occ:0.40
 CL A:CL311 0.0 43.0 0.4
CL A:CL311 2.0 33.5 0.6
NH1 A:ARG250 2.9 28.9 1.0
NH2 A:ARG250 3.3 29.3 1.0
CZ A:ARG250 3.6 28.8 1.0
CB A:PHE208 3.7 21.4 1.0
OAH A:ISS301 4.1 20.1 1.0
CAG A:ISS301 4.2 25.6 1.0
OG1 A:THR206 4.2 18.7 1.0
N A:PHE208 4.2 18.1 1.0
CAI A:ISS301 4.3 32.4 1.0
C A:GLY207 4.3 17.2 1.0
CAJ A:ISS301 4.4 34.2 1.0
O2 A:SO4307 4.4 29.3 0.3
CA A:GLY207 4.6 15.8 1.0
CA A:PHE208 4.6 19.8 1.0
OG A:SER115 4.7 21.4 1.0
N A:GLY207 4.7 15.8 1.0
CB A:THR206 4.7 19.3 1.0
CG A:PHE208 4.8 24.6 1.0
O A:GLY207 4.8 18.5 1.0
CD2 A:PHE208 4.8 28.5 1.0
O A:HOH534 4.8 35.4 1.0
NE A:ARG250 4.9 25.6 1.0
C A:THR206 5.0 16.4 1.0

Chlorine binding site 3 out of 4 in 7l5t

Go back to Chlorine Binding Sites List in 7l5t
Chlorine binding site 3 out of 4 in the Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl308

b:52.1
occ:0.60
 CL B:CL308 0.0 52.1 0.6
CL B:CL308 1.4 52.1 0.4
OG B:SER115 3.0 36.2 1.0
OG1 B:THR206 3.0 28.2 1.0
O B:THR206 3.6 26.3 1.0
OAH B:ISS301 3.6 33.7 1.0
C B:THR206 3.7 26.7 1.0
OG B:SER67 3.7 36.6 1.0
CB B:SER115 3.7 39.2 1.0
CB B:SER67 3.8 31.8 1.0
NH1 B:ARG250 3.8 43.0 1.0
CB B:THR206 3.9 27.3 1.0
N B:GLY207 3.9 28.4 1.0
CA B:GLY207 4.0 30.0 1.0
CAG B:ISS301 4.0 40.0 1.0
NZ B:LYS205 4.2 26.8 1.0
O B:HOH415 4.2 48.2 1.0
NH2 B:ARG250 4.4 44.4 1.0
CA B:THR206 4.4 26.1 1.0
C B:GLY207 4.4 31.3 1.0
N B:PHE208 4.5 33.2 1.0
CZ B:ARG250 4.5 41.5 1.0
CAI B:ISS301 4.5 53.5 1.0
CAJ B:ISS301 4.6 59.0 1.0

Chlorine binding site 4 out of 4 in 7l5t

Go back to Chlorine Binding Sites List in 7l5t
Chlorine binding site 4 out of 4 in the Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended- Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl308

b:52.1
occ:0.40
 CL B:CL308 0.0 52.1 0.4
CL B:CL308 1.4 52.1 0.6
NH1 B:ARG250 2.9 43.0 1.0
NH2 B:ARG250 3.6 44.4 1.0
OAH B:ISS301 3.7 33.7 1.0
CZ B:ARG250 3.7 41.5 1.0
OG1 B:THR206 3.7 28.2 1.0
N B:PHE208 3.8 33.2 1.0
CB B:PHE208 3.9 37.8 1.0
C B:GLY207 4.0 31.3 1.0
CA B:GLY207 4.0 30.0 1.0
N B:GLY207 4.1 28.4 1.0
CB B:THR206 4.2 27.3 1.0
C B:THR206 4.3 26.7 1.0
OG B:SER115 4.3 36.2 1.0
CAG B:ISS301 4.3 40.0 1.0
CAJ B:ISS301 4.3 59.0 1.0
O B:THR206 4.4 26.3 1.0
OG B:SER67 4.4 36.6 1.0
O B:HOH415 4.5 48.2 1.0
CA B:PHE208 4.5 35.9 1.0
O B:GLY207 4.6 30.9 1.0
CAI B:ISS301 4.6 53.5 1.0
CB B:SER67 4.7 31.8 1.0
CB B:SER115 4.8 39.2 1.0
CA B:THR206 4.9 26.1 1.0
NE B:ARG250 5.0 39.3 1.0

Reference:

G.Minasov, L.Shuvalova, M.Rosas-Lemus, J.S.Brunzelle, K.J.F.Satchell, Center For Structural Genomics Of Infectious Diseases(Csgid). Crystal Structure of the Oxacillin-Hydrolyzing Class D Extended-Spectrum Beta-Lactamase Oxa-14 From Pseudomonas Aeruginosa in Complex with Covalently Bound Clavulanic Acid To Be Published.
Page generated: Mon Jul 29 23:52:53 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy