Chlorine in PDB 7l6r: Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1), S-Adenosyl-L-Homocysteine (Sah) and Manganese (Mn).

The structure of Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1), S-Adenosyl-L-Homocysteine (Sah) and Manganese (Mn)., PDB code: 7l6r was solved by G.Minasov, L.Shuvalova, M.Rosas-Lemus, O.Kiryukhina, J.S.Brunzelle, K.J.F.Satchell, Center For Structural Genomics Of Infectious Diseases(Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.95 / 1.98
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	168.757, 168.757, 52.272, 90, 90, 120
R / Rfree (%)	15 / 16.6

The structure of Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1), S-Adenosyl-L-Homocysteine (Sah) and Manganese (Mn). also contains other interesting chemical elements:

Zinc	(Zn)	1 atom
Manganese	(Mn)	1 atom

The binding sites of Chlorine atom in the Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1), S-Adenosyl-L-Homocysteine (Sah) and Manganese (Mn). (pdb code 7l6r). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1), S-Adenosyl-L-Homocysteine (Sah) and Manganese (Mn)., PDB code: 7l6r:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1), S-Adenosyl-L-Homocysteine (Sah) and Manganese (Mn).


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1), S-Adenosyl-L-Homocysteine (Sah) and Manganese (Mn). within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl7102 b:65.7 occ:0.80 O A:HOH7399 2.8 67.2 1.0 O A:HOH7340 2.9 55.0 1.0 OD1 A:ASN6853 3.2 29.6 1.0 N A:LYS7051 3.2 49.3 1.0 CG A:LYS7051 3.5 63.5 1.0 CG A:ASN6853 3.6 29.1 1.0 CD1 A:LEU7050 3.7 32.6 1.0 O A:HOH7303 3.7 50.6 1.0 CA A:LEU7050 3.8 33.0 1.0 CB A:ASN6853 3.8 29.0 1.0 O A:PRO7049 4.0 33.5 1.0 C A:LEU7050 4.0 36.4 1.0 O A:ASN6853 4.0 30.2 1.0 CB A:LYS7051 4.0 57.4 1.0 CA A:ASN6853 4.1 28.7 1.0 CA A:LYS7051 4.2 53.3 1.0 ND2 A:ASN6853 4.4 28.7 1.0 CD A:LYS7051 4.5 70.7 1.0 O A:HOH7285 4.5 38.9 1.0 C A:ASN6853 4.6 28.5 1.0 CG A:LEU7050 4.7 32.8 1.0 N A:LEU7050 4.7 31.8 1.0 C A:PRO7049 4.7 33.1 1.0 CB A:LEU7050 4.7 32.1 1.0 CE A:LYS7051 4.8 76.4 1.0 O A:HOH7406 5.0 62.9 1.0

Chlorine binding site 2 out of 3 in the Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1), S-Adenosyl-L-Homocysteine (Sah) and Manganese (Mn).


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1), S-Adenosyl-L-Homocysteine (Sah) and Manganese (Mn). within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl7103 b:54.5 occ:0.65 CL A:CL7103 0.0 54.5 0.7 CL A:CL7103 2.0 57.8 0.3 O A:HOH7296 2.9 64.8 1.0 N A:GLU6945 2.9 36.0 0.6 N A:GLU6945 2.9 35.8 0.4 CA A:LYS6944 3.6 33.1 1.0 C A:LYS6944 3.7 34.8 1.0 CA A:GLU6945 3.9 37.3 0.6 CB A:GLU6945 3.9 40.0 0.6 CA A:GLU6945 3.9 36.7 0.4 CB A:LYS6944 4.0 32.3 1.0 CB A:GLU6945 4.0 39.0 0.4 CD A:LYS6944 4.1 32.7 1.0 O A:HOH7468 4.2 64.4 1.0 CG A:GLU6945 4.3 42.7 0.6 C A:GLU6945 4.3 36.5 0.6 C A:GLU6945 4.4 36.1 0.4 N A:GLY6946 4.6 36.5 1.0 CG A:GLU6945 4.6 40.8 0.4 O A:SER6943 4.7 33.5 1.0 CG A:LYS6944 4.7 31.2 1.0 N A:LYS6944 4.9 31.3 1.0 O A:HOH7250 5.0 55.5 1.0 O A:GLU6945 5.0 36.8 0.6 O A:LYS6944 5.0 34.7 1.0 CD A:GLU6945 5.0 46.4 0.6

Chlorine binding site 3 out of 3 in the Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1), S-Adenosyl-L-Homocysteine (Sah) and Manganese (Mn).


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1), S-Adenosyl-L-Homocysteine (Sah) and Manganese (Mn). within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl7103 b:57.8 occ:0.35 CL A:CL7103 0.0 57.8 0.3 CL A:CL7103 2.0 54.5 0.7 N A:GLU6945 4.0 36.0 0.6 N A:GLU6945 4.0 35.8 0.4 N A:GLY6946 4.2 36.5 1.0 O A:HOH7250 4.2 55.5 1.0 C A:GLU6945 4.4 36.5 0.6 C A:GLU6945 4.4 36.1 0.4 O A:HOH7378 4.5 56.0 1.0 CA A:GLU6945 4.6 37.3 0.6 CA A:GLY6946 4.6 35.3 1.0 CA A:GLU6945 4.6 36.7 0.4 CB A:GLU6945 4.7 40.0 0.6 OD2 A:ASP6931 4.8 46.4 1.0 O A:HOH7429 4.8 47.5 1.0 O A:HOH7296 4.8 64.8 1.0 CB A:GLU6945 4.8 39.0 0.4 CB A:LYS6944 4.9 32.3 1.0 O A:GLU6945 4.9 36.8 0.6 O A:HOH7450 4.9 46.5 0.6 O A:GLU6945 4.9 35.8 0.4 C A:LYS6944 5.0 34.8 1.0 CA A:LYS6944 5.0 33.1 1.0

G.Minasov, L.Shuvalova, M.Rosas-Lemus, O.Kiryukhina, J.S.Brunzelle, K.J.F.Satchell, Center For Structural Genomics Of Infectious Diseases(Csgid). Crystal Structure of Sars-Cov-2 NSP16/10 Heterodimer in Complex with (M7GPPPA2M)Pupupapapa (Cap-1), S-Adenosyl-L-Homocysteine (Sah) and Manganese (Mn). To Be Published.