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Chlorine in PDB 7lal: Crystal Structure of Myeloperoxidase Subform C (Mpo) Complex with Compound-18 Aka 7-(3-(2,3-Dihydro-1H-Inden-1-Ylamino)-1- Phenylpropyl)-1H-[1,2,3]Triazolo[4,5-B]Pyridin-5-AmineEnzymatic activity of Crystal Structure of Myeloperoxidase Subform C (Mpo) Complex with Compound-18 Aka 7-(3-(2,3-Dihydro-1H-Inden-1-Ylamino)-1- Phenylpropyl)-1H-[1,2,3]Triazolo[4,5-B]Pyridin-5-Amine
All present enzymatic activity of Crystal Structure of Myeloperoxidase Subform C (Mpo) Complex with Compound-18 Aka 7-(3-(2,3-Dihydro-1H-Inden-1-Ylamino)-1- Phenylpropyl)-1H-[1,2,3]Triazolo[4,5-B]Pyridin-5-Amine:
1.11.2.2; Protein crystallography data
The structure of Crystal Structure of Myeloperoxidase Subform C (Mpo) Complex with Compound-18 Aka 7-(3-(2,3-Dihydro-1H-Inden-1-Ylamino)-1- Phenylpropyl)-1H-[1,2,3]Triazolo[4,5-B]Pyridin-5-Amine, PDB code: 7lal
was solved by
J.A.Khan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7lal:
The structure of Crystal Structure of Myeloperoxidase Subform C (Mpo) Complex with Compound-18 Aka 7-(3-(2,3-Dihydro-1H-Inden-1-Ylamino)-1- Phenylpropyl)-1H-[1,2,3]Triazolo[4,5-B]Pyridin-5-Amine also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Myeloperoxidase Subform C (Mpo) Complex with Compound-18 Aka 7-(3-(2,3-Dihydro-1H-Inden-1-Ylamino)-1- Phenylpropyl)-1H-[1,2,3]Triazolo[4,5-B]Pyridin-5-Amine
(pdb code 7lal). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Myeloperoxidase Subform C (Mpo) Complex with Compound-18 Aka 7-(3-(2,3-Dihydro-1H-Inden-1-Ylamino)-1- Phenylpropyl)-1H-[1,2,3]Triazolo[4,5-B]Pyridin-5-Amine, PDB code: 7lal: Chlorine binding site 1 out of 1 in 7lalGo back to Chlorine Binding Sites List in 7lal
Chlorine binding site 1 out
of 1 in the Crystal Structure of Myeloperoxidase Subform C (Mpo) Complex with Compound-18 Aka 7-(3-(2,3-Dihydro-1H-Inden-1-Ylamino)-1- Phenylpropyl)-1H-[1,2,3]Triazolo[4,5-B]Pyridin-5-Amine
Mono view Stereo pair view
Reference:
C.H.Hu,
M.W.Neissel Valente,
O.Scott Halpern,
S.Jusuf,
J.A.Khan,
G.A.Locke,
G.J.Duke,
X.Liu,
F.J.Duclos,
R.R.Wexler,
E.K.Kick,
J.M.Smallheer.
Small Molecule and Macrocyclic Pyrazole Derived Inhibitors of Myeloperoxidase (Mpo). Bioorg.Med.Chem.Lett. 28010 2021.
Page generated: Sat Jul 10 12:52:24 2021
ISSN: ESSN 1464-3405 PubMed: 33811992 DOI: 10.1016/J.BMCL.2021.128010 |
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