Chlorine in PDB 7lc4: Crystal Structure of Pseudomonas Aeruginosa PBP3 in Complex with Gamma-Lactam YU253911

All present enzymatic activity of Crystal Structure of Pseudomonas Aeruginosa PBP3 in Complex with Gamma-Lactam YU253911:
3.4.16.4;

The structure of Crystal Structure of Pseudomonas Aeruginosa PBP3 in Complex with Gamma-Lactam YU253911, PDB code: 7lc4 was solved by F.Van Den Akker, V.Kumar, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.91 / 2.00
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	67.765, 82.661, 88.799, 90, 90, 90
R / Rfree (%)	17.5 / 22.7

The binding sites of Chlorine atom in the Crystal Structure of Pseudomonas Aeruginosa PBP3 in Complex with Gamma-Lactam YU253911 (pdb code 7lc4). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Pseudomonas Aeruginosa PBP3 in Complex with Gamma-Lactam YU253911, PDB code: 7lc4:

Chlorine binding site 1 out of 1 in the Crystal Structure of Pseudomonas Aeruginosa PBP3 in Complex with Gamma-Lactam YU253911


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Pseudomonas Aeruginosa PBP3 in Complex with Gamma-Lactam YU253911 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl601 b:23.5 occ:0.58 CL1 A:XVG601 0.0 23.5 0.6 C26 A:XVG601 1.7 24.8 1.0 C24 A:XVG601 2.8 26.8 1.0 S1 A:XVG601 2.9 28.6 1.0 C5 A:XVG601 3.0 25.0 1.0 O A:TYR407 3.0 22.1 1.0 N2 A:XVG601 3.2 21.9 1.0 CA A:GLY293 3.3 23.2 1.0 C4 A:XVG601 3.3 28.5 1.0 O2 A:XVG601 3.4 22.9 1.0 C6 A:XVG601 3.6 20.6 1.0 CD1 A:TYR407 3.8 22.2 1.0 C A:GLY293 4.0 19.4 1.0 N7 A:XVG601 4.0 23.3 1.0 O3 A:XVG601 4.0 20.8 1.0 C A:TYR407 4.0 21.7 1.0 C25 A:XVG601 4.1 27.9 1.0 C7 A:XVG601 4.1 20.3 1.0 N A:TYR409 4.1 22.2 1.0 N A:SER294 4.2 17.8 1.0 C A:GLY408 4.2 21.9 1.0 CB A:TYR409 4.2 27.7 1.0 CA A:TYR409 4.3 25.7 1.0 O A:GLY408 4.4 24.4 1.0 CE1 A:TYR407 4.4 27.4 1.0 OG A:SER294 4.5 19.5 1.0 N A:GLY293 4.5 23.4 1.0 N1 A:XVG601 4.6 33.7 1.0 O A:THR487 4.7 22.4 1.0 CG A:TYR407 4.7 22.3 1.0 N A:GLY408 4.8 19.1 1.0 CA A:GLY408 4.8 21.3 1.0 CB A:TYR407 4.8 21.4 1.0 O A:GLY293 4.9 20.5 1.0 C8 A:XVG601 5.0 21.9 1.0 CD2 A:TYR409 5.0 38.5 1.0

J.Goldberg, V.Kumar, F.Van Den Akker, M.Plummer, R.A.Bonomo. A Gamma-Lactam Siderophore Antibiotic Effective Against Multidrug-Resistant P. Aeruginosa, K. Pneumoniae, and Acinetobacter Spp. To Be Published.