Chlorine in PDB 7lfv: Crystal Structure of the Sars Cov-1 Papain-Like Protease in Complex with Peptide Inhibitor VIR251

Enzymatic activity of Crystal Structure of the Sars Cov-1 Papain-Like Protease in Complex with Peptide Inhibitor VIR251

All present enzymatic activity of Crystal Structure of the Sars Cov-1 Papain-Like Protease in Complex with Peptide Inhibitor VIR251:
3.4.19.12; 3.4.22.69;

Protein crystallography data

The structure of Crystal Structure of the Sars Cov-1 Papain-Like Protease in Complex with Peptide Inhibitor VIR251, PDB code: 7lfv was solved by S.K.Olsen, Z.Lv, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 53.34 / 2.23
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 103.61, 103.61, 265.354, 90, 90, 120
R / Rfree (%) 19.7 / 23.5

Other elements in 7lfv:

The structure of Crystal Structure of the Sars Cov-1 Papain-Like Protease in Complex with Peptide Inhibitor VIR251 also contains other interesting chemical elements:

Zinc (Zn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of the Sars Cov-1 Papain-Like Protease in Complex with Peptide Inhibitor VIR251 (pdb code 7lfv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the Sars Cov-1 Papain-Like Protease in Complex with Peptide Inhibitor VIR251, PDB code: 7lfv:

Chlorine binding site 1 out of 1 in 7lfv

Go back to Chlorine Binding Sites List in 7lfv
Chlorine binding site 1 out of 1 in the Crystal Structure of the Sars Cov-1 Papain-Like Protease in Complex with Peptide Inhibitor VIR251


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Sars Cov-1 Papain-Like Protease in Complex with Peptide Inhibitor VIR251 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl2013

b:85.2
occ:1.00
OG1 A:THR19 3.6 55.3 1.0
N A:THR19 3.6 52.6 1.0
CA A:HIS18 4.1 43.5 1.0
CB A:THR19 4.2 52.7 1.0
NZ B:LYS293 4.2 86.6 1.0
O A:LEU17 4.2 55.3 1.0
C A:HIS18 4.4 48.0 1.0
CA A:THR19 4.5 49.8 1.0
CB A:HIS18 4.9 44.8 1.0

Reference:

S.Patchett, Z.Lv, W.Rut, M.Bekes, M.Drag, S.K.Olsen, T.T.Huang. A Molecular Sensor Determines the Ubiquitin Substrate Specificity of Sars-Cov-2 Papain-Like Protease. Cell Rep V. 36 09754 2021.
ISSN: ESSN 2211-1247
PubMed: 34547223
DOI: 10.1016/J.CELREP.2021.109754
Page generated: Tue Jul 30 00:01:49 2024

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