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Chlorine in PDB 7lhb: Crystal Structure of Bcl-2 in Complex with Prodrug Abbv-167Protein crystallography data
The structure of Crystal Structure of Bcl-2 in Complex with Prodrug Abbv-167, PDB code: 7lhb
was solved by
R.A.Judge,
A.H.Salem,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Bcl-2 in Complex with Prodrug Abbv-167
(pdb code 7lhb). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of Bcl-2 in Complex with Prodrug Abbv-167, PDB code: 7lhb: Jump to Chlorine binding site number: 1; 2; 3; Chlorine binding site 1 out of 3 in 7lhbGo back to Chlorine Binding Sites List in 7lhb
Chlorine binding site 1 out
of 3 in the Crystal Structure of Bcl-2 in Complex with Prodrug Abbv-167
Mono view Stereo pair view
Chlorine binding site 2 out of 3 in 7lhbGo back to Chlorine Binding Sites List in 7lhb
Chlorine binding site 2 out
of 3 in the Crystal Structure of Bcl-2 in Complex with Prodrug Abbv-167
Mono view Stereo pair view
Chlorine binding site 3 out of 3 in 7lhbGo back to Chlorine Binding Sites List in 7lhb
Chlorine binding site 3 out
of 3 in the Crystal Structure of Bcl-2 in Complex with Prodrug Abbv-167
Mono view Stereo pair view
Reference:
A.H.Salem,
Z.F.Tao,
O.F.Bueno,
J.Chen,
S.Chen,
R.Edalji,
S.W.Elmore,
K.M.Fournier,
K.C.Harper,
R.Hong,
G.J.Jenkins,
J.Ji,
R.A.Judge,
J.C.Kalvass,
R.C.Klix,
Y.Y.Ku,
J.D.Leverson,
R.A.Marks,
K.C.Marsh,
R.M.Menon,
C.H.Park,
D.C.Phillips,
Y.M.Pu,
S.H.Rosenberg,
Y.D.Sanzgiri,
A.Y.Sheikh,
Y.Shi,
D.Stolarik,
A.A.Suleiman,
X.Wang,
G.G.Z.Zhang,
N.D.Catron,
A.J.Souers.
Expanding the Repertoire For "Large Small Molecules" : Prodrug Abbv-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers. Mol.Cancer Ther. 2021.
Page generated: Sat Apr 17 15:15:04 2021
ISSN: ESSN 1538-8514 PubMed: 33785651 DOI: 10.1158/1535-7163.MCT-21-0077 |
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