Chlorine in PDB 7lmw: Receptor For Advanced Glycation End Products VC1 Domain in Complex with 3-(3-((4-(4-Carboxyphenoxy)Benzyl)Oxy)Phenyl)-1H-Indole-2- Carboxylic Acid

The structure of Receptor For Advanced Glycation End Products VC1 Domain in Complex with 3-(3-((4-(4-Carboxyphenoxy)Benzyl)Oxy)Phenyl)-1H-Indole-2- Carboxylic Acid, PDB code: 7lmw was solved by L.E.Salay, N.Kozlyuk, B.A.Gilston, R.D.Gogliotti, P.P.Christov, K.Kim, M.Ovee, A.G.Waterson, W.J.Chazin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.41 / 2.50
Space group	P 62
Cell size a, b, c (Å), α, β, γ (°)	101.885, 101.885, 102.306, 90, 90, 120
R / Rfree (%)	20 / 25.6

The binding sites of Chlorine atom in the Receptor For Advanced Glycation End Products VC1 Domain in Complex with 3-(3-((4-(4-Carboxyphenoxy)Benzyl)Oxy)Phenyl)-1H-Indole-2- Carboxylic Acid (pdb code 7lmw). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Receptor For Advanced Glycation End Products VC1 Domain in Complex with 3-(3-((4-(4-Carboxyphenoxy)Benzyl)Oxy)Phenyl)-1H-Indole-2- Carboxylic Acid, PDB code: 7lmw:

Chlorine binding site 1 out of 1 in the Receptor For Advanced Glycation End Products VC1 Domain in Complex with 3-(3-((4-(4-Carboxyphenoxy)Benzyl)Oxy)Phenyl)-1H-Indole-2- Carboxylic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Receptor For Advanced Glycation End Products VC1 Domain in Complex with 3-(3-((4-(4-Carboxyphenoxy)Benzyl)Oxy)Phenyl)-1H-Indole-2- Carboxylic Acid within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl505 b:50.5 occ:1.00 N B:ARG179 3.1 31.4 1.0 CA B:ARG178 3.7 32.3 1.0 C B:ARG178 3.9 38.1 1.0 O B:ARG179 3.9 34.7 1.0 CB B:ARG178 4.0 35.2 1.0 CA B:ARG179 4.1 36.0 1.0 CB B:ARG179 4.1 32.7 1.0 CG B:ARG178 4.3 62.7 1.0 C B:ARG179 4.4 37.4 1.0 O B:THR177 4.6 40.1 1.0 N B:ARG178 4.9 35.3 1.0

N.Kozlyuk, B.A.Gilston, L.E.Salay, R.D.Gogliotti, P.P.Christov, K.Kim, M.Ovee, A.G.Waterson, W.J.Chazin. A Fragment-Based Approach to Discovery of Receptor For Advanced Glycation End Products Inhibitors. Proteins 2021.
ISSN: ESSN 1097-0134
PubMed: 34156100
DOI: 10.1002/PROT.26162