Chlorine in PDB 7m18: Hela-Tubulin in Complex with Cryptophycin 1

The binding sites of Chlorine atom in the Hela-Tubulin in Complex with Cryptophycin 1 (pdb code 7m18). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 8 binding sites of Chlorine where determined in the Hela-Tubulin in Complex with Cryptophycin 1, PDB code: 7m18:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Chlorine binding site 1 out of 8 in the Hela-Tubulin in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Hela-Tubulin in Complex with Cryptophycin 1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl501 b:126.3 occ:1.00 CL1 B:YNP501 0.0 126.3 1.0 C31 B:YNP501 1.8 126.3 1.0 C35 B:YNP501 2.6 126.3 1.0 C32 B:YNP501 2.7 126.3 1.0 C30 B:YNP501 2.8 126.3 1.0 O8 B:YNP501 3.0 126.3 1.0 CB A:CYS347 3.3 150.8 1.0 SG A:CYS347 3.5 150.8 1.0 C33 B:YNP501 4.0 126.3 1.0 C29 B:YNP501 4.1 126.3 1.0 CE2 B:PHE394 4.4 116.1 1.0 O A:MET313 4.5 154.5 1.0 C34 B:YNP501 4.5 126.3 1.0 O A:PRO348 4.7 149.7 1.0 CA A:CYS347 4.8 150.8 1.0 CZ B:PHE394 4.8 116.1 1.0 NE1 A:TRP346 5.0 146.2 1.0

Chlorine binding site 2 out of 8 in the Hela-Tubulin in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Hela-Tubulin in Complex with Cryptophycin 1 within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl501 b:126.3 occ:1.00 CL1 D:YNP501 0.0 126.3 1.0 C31 D:YNP501 1.8 126.3 1.0 C35 D:YNP501 2.6 126.3 1.0 C32 D:YNP501 2.8 126.3 1.0 C30 D:YNP501 2.8 126.3 1.0 O8 D:YNP501 3.0 126.3 1.0 CB C:CYS347 3.3 150.8 1.0 SG C:CYS347 3.5 150.8 1.0 C33 D:YNP501 4.0 126.3 1.0 C29 D:YNP501 4.1 126.3 1.0 CE2 D:PHE394 4.4 116.1 1.0 O C:MET313 4.5 154.5 1.0 C34 D:YNP501 4.5 126.3 1.0 O C:PRO348 4.7 149.7 1.0 CA C:CYS347 4.8 150.8 1.0 CZ D:PHE394 4.8 116.1 1.0 NE1 C:TRP346 5.0 146.2 1.0

Chlorine binding site 3 out of 8 in the Hela-Tubulin in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Hela-Tubulin in Complex with Cryptophycin 1 within 5.0Å range: probe atom residue distance (Å) B Occ F:Cl501 b:126.3 occ:1.00 CL1 F:YNP501 0.0 126.3 1.0 C31 F:YNP501 1.8 126.3 1.0 C35 F:YNP501 2.6 126.3 1.0 C32 F:YNP501 2.7 126.3 1.0 C30 F:YNP501 2.8 126.3 1.0 O8 F:YNP501 3.0 126.3 1.0 CB E:CYS347 3.3 150.8 1.0 SG E:CYS347 3.5 150.8 1.0 C33 F:YNP501 4.0 126.3 1.0 C29 F:YNP501 4.1 126.3 1.0 CE2 F:PHE394 4.4 116.1 1.0 O E:MET313 4.5 154.5 1.0 C34 F:YNP501 4.5 126.3 1.0 O E:PRO348 4.7 149.7 1.0 CA E:CYS347 4.8 150.8 1.0 CZ F:PHE394 4.8 116.1 1.0 NE1 E:TRP346 5.0 146.2 1.0

Chlorine binding site 4 out of 8 in the Hela-Tubulin in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Hela-Tubulin in Complex with Cryptophycin 1 within 5.0Å range: probe atom residue distance (Å) B Occ H:Cl501 b:126.3 occ:1.00 CL1 H:YNP501 0.0 126.3 1.0 C31 H:YNP501 1.8 126.3 1.0 C35 H:YNP501 2.6 126.3 1.0 C32 H:YNP501 2.8 126.3 1.0 C30 H:YNP501 2.8 126.3 1.0 O8 H:YNP501 3.0 126.3 1.0 CB G:CYS347 3.3 150.8 1.0 SG G:CYS347 3.5 150.8 1.0 C33 H:YNP501 4.0 126.3 1.0 C29 H:YNP501 4.1 126.3 1.0 CE2 H:PHE394 4.4 116.1 1.0 O G:MET313 4.5 154.5 1.0 C34 H:YNP501 4.5 126.3 1.0 O G:PRO348 4.7 149.7 1.0 CA G:CYS347 4.8 150.8 1.0 CZ H:PHE394 4.8 116.1 1.0 NE1 G:TRP346 5.0 146.2 1.0

Chlorine binding site 5 out of 8 in the Hela-Tubulin in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Hela-Tubulin in Complex with Cryptophycin 1 within 5.0Å range: probe atom residue distance (Å) B Occ J:Cl501 b:126.3 occ:1.00 CL1 J:YNP501 0.0 126.3 1.0 C31 J:YNP501 1.8 126.3 1.0 C35 J:YNP501 2.6 126.3 1.0 C32 J:YNP501 2.7 126.3 1.0 C30 J:YNP501 2.8 126.3 1.0 O8 J:YNP501 3.0 126.3 1.0 CB I:CYS347 3.3 150.8 1.0 SG I:CYS347 3.5 150.8 1.0 C33 J:YNP501 4.0 126.3 1.0 C29 J:YNP501 4.1 126.3 1.0 CE2 J:PHE394 4.4 116.1 1.0 O I:MET313 4.5 154.5 1.0 C34 J:YNP501 4.5 126.3 1.0 O I:PRO348 4.7 149.7 1.0 CA I:CYS347 4.8 150.8 1.0 CZ J:PHE394 4.8 116.1 1.0 NE1 I:TRP346 5.0 146.2 1.0

Chlorine binding site 6 out of 8 in the Hela-Tubulin in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Hela-Tubulin in Complex with Cryptophycin 1 within 5.0Å range: probe atom residue distance (Å) B Occ L:Cl501 b:126.3 occ:1.00 CL1 L:YNP501 0.0 126.3 1.0 C31 L:YNP501 1.8 126.3 1.0 C35 L:YNP501 2.6 126.3 1.0 C32 L:YNP501 2.8 126.3 1.0 C30 L:YNP501 2.8 126.3 1.0 O8 L:YNP501 3.0 126.3 1.0 CB K:CYS347 3.3 150.8 1.0 SG K:CYS347 3.5 150.8 1.0 C33 L:YNP501 4.0 126.3 1.0 C29 L:YNP501 4.1 126.3 1.0 CE2 L:PHE394 4.4 116.1 1.0 O K:MET313 4.5 154.5 1.0 C34 L:YNP501 4.5 126.3 1.0 O K:PRO348 4.7 149.7 1.0 CA K:CYS347 4.8 150.8 1.0 CZ L:PHE394 4.8 116.1 1.0 NE1 K:TRP346 5.0 146.2 1.0

Chlorine binding site 7 out of 8 in the Hela-Tubulin in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Hela-Tubulin in Complex with Cryptophycin 1 within 5.0Å range: probe atom residue distance (Å) B Occ N:Cl501 b:126.3 occ:1.00 CL1 N:YNP501 0.0 126.3 1.0 C31 N:YNP501 1.8 126.3 1.0 C35 N:YNP501 2.6 126.3 1.0 C32 N:YNP501 2.7 126.3 1.0 C30 N:YNP501 2.8 126.3 1.0 O8 N:YNP501 3.0 126.3 1.0 CB M:CYS347 3.3 150.8 1.0 SG M:CYS347 3.5 150.8 1.0 C33 N:YNP501 4.0 126.3 1.0 C29 N:YNP501 4.1 126.3 1.0 CE2 N:PHE394 4.4 116.1 1.0 O M:MET313 4.5 154.5 1.0 C34 N:YNP501 4.5 126.3 1.0 O M:PRO348 4.7 149.7 1.0 CA M:CYS347 4.8 150.8 1.0 CZ N:PHE394 4.8 116.1 1.0 NE1 M:TRP346 5.0 146.2 1.0

Chlorine binding site 8 out of 8 in the Hela-Tubulin in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Hela-Tubulin in Complex with Cryptophycin 1 within 5.0Å range: probe atom residue distance (Å) B Occ P:Cl501 b:126.3 occ:1.00 CL1 P:YNP501 0.0 126.3 1.0 C31 P:YNP501 1.8 126.3 1.0 C35 P:YNP501 2.6 126.3 1.0 C32 P:YNP501 2.8 126.3 1.0 C30 P:YNP501 2.8 126.3 1.0 O8 P:YNP501 3.0 126.3 1.0 CB O:CYS347 3.3 150.8 1.0 SG O:CYS347 3.5 150.8 1.0 C33 P:YNP501 4.0 126.3 1.0 C29 P:YNP501 4.1 126.3 1.0 CE2 P:PHE394 4.4 116.1 1.0 O O:MET313 4.5 154.5 1.0 C34 P:YNP501 4.5 126.3 1.0 O O:PRO348 4.7 149.7 1.0 CA O:CYS347 4.8 150.8 1.0 CZ P:PHE394 4.8 116.1 1.0 NE1 O:TRP346 5.0 146.2 1.0

E.Eren, N.R.Watts, D.L.Sackett, P.T.Wingfield. Conformational Changes in Tubulin Upon Binding Cryptophycin-52 Reveal Its Mechanism of Action J.Biol.Chem. 2021.
ISSN: ESSN 1083-351X
DOI: 10.1016/J.JBC.2021.101138