Chlorine in PDB 7m18: Hela-Tubulin in Complex with Cryptophycin 1

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Hela-Tubulin in Complex with Cryptophycin 1 (pdb code 7m18). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 8 binding sites of Chlorine where determined in the Hela-Tubulin in Complex with Cryptophycin 1, PDB code: 7m18:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Chlorine binding site 1 out of 8 in 7m18

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Chlorine binding site 1 out of 8 in the Hela-Tubulin in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Hela-Tubulin in Complex with Cryptophycin 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl501

b:126.3
occ:1.00
 CL1 B:YNP501 0.0 126.3 1.0
C31 B:YNP501 1.8 126.3 1.0
C35 B:YNP501 2.6 126.3 1.0
C32 B:YNP501 2.7 126.3 1.0
C30 B:YNP501 2.8 126.3 1.0
O8 B:YNP501 3.0 126.3 1.0
CB A:CYS347 3.3 150.8 1.0
SG A:CYS347 3.5 150.8 1.0
C33 B:YNP501 4.0 126.3 1.0
C29 B:YNP501 4.1 126.3 1.0
CE2 B:PHE394 4.4 116.1 1.0
O A:MET313 4.5 154.5 1.0
C34 B:YNP501 4.5 126.3 1.0
O A:PRO348 4.7 149.7 1.0
CA A:CYS347 4.8 150.8 1.0
CZ B:PHE394 4.8 116.1 1.0
NE1 A:TRP346 5.0 146.2 1.0

Chlorine binding site 2 out of 8 in 7m18

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Chlorine binding site 2 out of 8 in the Hela-Tubulin in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Hela-Tubulin in Complex with Cryptophycin 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl501

b:126.3
occ:1.00
 CL1 D:YNP501 0.0 126.3 1.0
C31 D:YNP501 1.8 126.3 1.0
C35 D:YNP501 2.6 126.3 1.0
C32 D:YNP501 2.8 126.3 1.0
C30 D:YNP501 2.8 126.3 1.0
O8 D:YNP501 3.0 126.3 1.0
CB C:CYS347 3.3 150.8 1.0
SG C:CYS347 3.5 150.8 1.0
C33 D:YNP501 4.0 126.3 1.0
C29 D:YNP501 4.1 126.3 1.0
CE2 D:PHE394 4.4 116.1 1.0
O C:MET313 4.5 154.5 1.0
C34 D:YNP501 4.5 126.3 1.0
O C:PRO348 4.7 149.7 1.0
CA C:CYS347 4.8 150.8 1.0
CZ D:PHE394 4.8 116.1 1.0
NE1 C:TRP346 5.0 146.2 1.0

Chlorine binding site 3 out of 8 in 7m18

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Chlorine binding site 3 out of 8 in the Hela-Tubulin in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Hela-Tubulin in Complex with Cryptophycin 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Cl501

b:126.3
occ:1.00
 CL1 F:YNP501 0.0 126.3 1.0
C31 F:YNP501 1.8 126.3 1.0
C35 F:YNP501 2.6 126.3 1.0
C32 F:YNP501 2.7 126.3 1.0
C30 F:YNP501 2.8 126.3 1.0
O8 F:YNP501 3.0 126.3 1.0
CB E:CYS347 3.3 150.8 1.0
SG E:CYS347 3.5 150.8 1.0
C33 F:YNP501 4.0 126.3 1.0
C29 F:YNP501 4.1 126.3 1.0
CE2 F:PHE394 4.4 116.1 1.0
O E:MET313 4.5 154.5 1.0
C34 F:YNP501 4.5 126.3 1.0
O E:PRO348 4.7 149.7 1.0
CA E:CYS347 4.8 150.8 1.0
CZ F:PHE394 4.8 116.1 1.0
NE1 E:TRP346 5.0 146.2 1.0

Chlorine binding site 4 out of 8 in 7m18

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Chlorine binding site 4 out of 8 in the Hela-Tubulin in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Hela-Tubulin in Complex with Cryptophycin 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Cl501

b:126.3
occ:1.00
 CL1 H:YNP501 0.0 126.3 1.0
C31 H:YNP501 1.8 126.3 1.0
C35 H:YNP501 2.6 126.3 1.0
C32 H:YNP501 2.8 126.3 1.0
C30 H:YNP501 2.8 126.3 1.0
O8 H:YNP501 3.0 126.3 1.0
CB G:CYS347 3.3 150.8 1.0
SG G:CYS347 3.5 150.8 1.0
C33 H:YNP501 4.0 126.3 1.0
C29 H:YNP501 4.1 126.3 1.0
CE2 H:PHE394 4.4 116.1 1.0
O G:MET313 4.5 154.5 1.0
C34 H:YNP501 4.5 126.3 1.0
O G:PRO348 4.7 149.7 1.0
CA G:CYS347 4.8 150.8 1.0
CZ H:PHE394 4.8 116.1 1.0
NE1 G:TRP346 5.0 146.2 1.0

Chlorine binding site 5 out of 8 in 7m18

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Chlorine binding site 5 out of 8 in the Hela-Tubulin in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Hela-Tubulin in Complex with Cryptophycin 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Cl501

b:126.3
occ:1.00
 CL1 J:YNP501 0.0 126.3 1.0
C31 J:YNP501 1.8 126.3 1.0
C35 J:YNP501 2.6 126.3 1.0
C32 J:YNP501 2.7 126.3 1.0
C30 J:YNP501 2.8 126.3 1.0
O8 J:YNP501 3.0 126.3 1.0
CB I:CYS347 3.3 150.8 1.0
SG I:CYS347 3.5 150.8 1.0
C33 J:YNP501 4.0 126.3 1.0
C29 J:YNP501 4.1 126.3 1.0
CE2 J:PHE394 4.4 116.1 1.0
O I:MET313 4.5 154.5 1.0
C34 J:YNP501 4.5 126.3 1.0
O I:PRO348 4.7 149.7 1.0
CA I:CYS347 4.8 150.8 1.0
CZ J:PHE394 4.8 116.1 1.0
NE1 I:TRP346 5.0 146.2 1.0

Chlorine binding site 6 out of 8 in 7m18

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Chlorine binding site 6 out of 8 in the Hela-Tubulin in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Hela-Tubulin in Complex with Cryptophycin 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
L:Cl501

b:126.3
occ:1.00
 CL1 L:YNP501 0.0 126.3 1.0
C31 L:YNP501 1.8 126.3 1.0
C35 L:YNP501 2.6 126.3 1.0
C32 L:YNP501 2.8 126.3 1.0
C30 L:YNP501 2.8 126.3 1.0
O8 L:YNP501 3.0 126.3 1.0
CB K:CYS347 3.3 150.8 1.0
SG K:CYS347 3.5 150.8 1.0
C33 L:YNP501 4.0 126.3 1.0
C29 L:YNP501 4.1 126.3 1.0
CE2 L:PHE394 4.4 116.1 1.0
O K:MET313 4.5 154.5 1.0
C34 L:YNP501 4.5 126.3 1.0
O K:PRO348 4.7 149.7 1.0
CA K:CYS347 4.8 150.8 1.0
CZ L:PHE394 4.8 116.1 1.0
NE1 K:TRP346 5.0 146.2 1.0

Chlorine binding site 7 out of 8 in 7m18

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Chlorine binding site 7 out of 8 in the Hela-Tubulin in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Hela-Tubulin in Complex with Cryptophycin 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
N:Cl501

b:126.3
occ:1.00
 CL1 N:YNP501 0.0 126.3 1.0
C31 N:YNP501 1.8 126.3 1.0
C35 N:YNP501 2.6 126.3 1.0
C32 N:YNP501 2.7 126.3 1.0
C30 N:YNP501 2.8 126.3 1.0
O8 N:YNP501 3.0 126.3 1.0
CB M:CYS347 3.3 150.8 1.0
SG M:CYS347 3.5 150.8 1.0
C33 N:YNP501 4.0 126.3 1.0
C29 N:YNP501 4.1 126.3 1.0
CE2 N:PHE394 4.4 116.1 1.0
O M:MET313 4.5 154.5 1.0
C34 N:YNP501 4.5 126.3 1.0
O M:PRO348 4.7 149.7 1.0
CA M:CYS347 4.8 150.8 1.0
CZ N:PHE394 4.8 116.1 1.0
NE1 M:TRP346 5.0 146.2 1.0

Chlorine binding site 8 out of 8 in 7m18

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Chlorine binding site 8 out of 8 in the Hela-Tubulin in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Hela-Tubulin in Complex with Cryptophycin 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
P:Cl501

b:126.3
occ:1.00
 CL1 P:YNP501 0.0 126.3 1.0
C31 P:YNP501 1.8 126.3 1.0
C35 P:YNP501 2.6 126.3 1.0
C32 P:YNP501 2.8 126.3 1.0
C30 P:YNP501 2.8 126.3 1.0
O8 P:YNP501 3.0 126.3 1.0
CB O:CYS347 3.3 150.8 1.0
SG O:CYS347 3.5 150.8 1.0
C33 P:YNP501 4.0 126.3 1.0
C29 P:YNP501 4.1 126.3 1.0
CE2 P:PHE394 4.4 116.1 1.0
O O:MET313 4.5 154.5 1.0
C34 P:YNP501 4.5 126.3 1.0
O O:PRO348 4.7 149.7 1.0
CA O:CYS347 4.8 150.8 1.0
CZ P:PHE394 4.8 116.1 1.0
NE1 O:TRP346 5.0 146.2 1.0

Reference:

E.Eren, N.R.Watts, D.L.Sackett, P.T.Wingfield. Conformational Changes in Tubulin Upon Binding Cryptophycin-52 Reveal Its Mechanism of Action J.Biol.Chem. 2021.
ISSN: ESSN 1083-351X
DOI: 10.1016/J.JBC.2021.101138
Page generated: Tue Jul 30 00:21:35 2024

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