Chlorine in PDB 7m19: Sn-407-LRRC8A in MSP1E3D1 Lipid Nanodiscs (Pose-2)

The binding sites of Chlorine atom in the Sn-407-LRRC8A in MSP1E3D1 Lipid Nanodiscs (Pose-2) (pdb code 7m19). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Sn-407-LRRC8A in MSP1E3D1 Lipid Nanodiscs (Pose-2), PDB code: 7m19:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Sn-407-LRRC8A in MSP1E3D1 Lipid Nanodiscs (Pose-2)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Sn-407-LRRC8A in MSP1E3D1 Lipid Nanodiscs (Pose-2) within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl902 b:89.2 occ:1.00 CL15 C:YNJ902 0.0 89.2 1.0 C11 C:YNJ902 1.8 89.2 1.0 C10 C:YNJ902 2.7 89.2 1.0 C12 C:YNJ902 2.8 89.2 1.0 O14 C:YNJ902 3.1 89.2 1.0 CL16 C:YNJ902 3.1 89.2 1.0 C13 C:YNJ902 3.4 89.2 1.0 C09 C:YNJ902 4.1 89.2 1.0 C07 C:YNJ902 4.1 89.2 1.0 CB D:ARG103 4.1 67.4 1.0 CD E:ARG103 4.3 64.4 1.0 CD D:ARG103 4.3 67.4 1.0 CB E:ARG103 4.4 64.4 1.0 C08 C:YNJ902 4.6 89.2 1.0 NE D:ARG103 4.7 67.4 1.0 CG E:ARG103 4.7 64.4 1.0 C05 C:YNJ902 4.8 89.2 1.0 CG D:ARG103 4.8 67.4 1.0

Chlorine binding site 2 out of 2 in the Sn-407-LRRC8A in MSP1E3D1 Lipid Nanodiscs (Pose-2)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Sn-407-LRRC8A in MSP1E3D1 Lipid Nanodiscs (Pose-2) within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl902 b:89.2 occ:1.00 CL16 C:YNJ902 0.0 89.2 1.0 C10 C:YNJ902 1.8 89.2 1.0 C11 C:YNJ902 2.8 89.2 1.0 C09 C:YNJ902 2.8 89.2 1.0 NH1 D:ARG103 2.9 67.4 1.0 NH1 E:ARG103 3.0 64.4 1.0 O17 C:YNJ902 3.0 89.2 1.0 CL15 C:YNJ902 3.1 89.2 1.0 CZ D:ARG103 3.4 67.4 1.0 CD D:ARG103 3.5 67.4 1.0 C18 C:YNJ902 3.5 89.2 1.0 NE D:ARG103 3.6 67.4 1.0 CD E:ARG103 3.6 64.4 1.0 NH1 C:ARG103 3.7 69.0 1.0 CZ E:ARG103 3.8 64.4 1.0 C20 C:YNJ902 4.0 89.2 1.0 NE E:ARG103 4.0 64.4 1.0 C12 C:YNJ902 4.1 89.2 1.0 C08 C:YNJ902 4.1 89.2 1.0 C19 C:YNJ902 4.2 89.2 1.0 NH2 D:ARG103 4.3 67.4 1.0 C21 C:YNJ902 4.4 89.2 1.0 C07 C:YNJ902 4.6 89.2 1.0 NH2 E:ARG103 4.8 64.4 1.0 CG D:ARG103 4.8 67.4 1.0 CG E:ARG103 4.9 64.4 1.0

S.K.Gunasekar, L.Xie, P.R.Chheda, C.Kang, D.M.Kern, C.My-Ta, A.Kumar, J.Maurer, E.E.Gerber, W.J.Grzesik, M.Elliot-Hudson, Y.Zhang, C.A.Kulkarni, I.Samuel, J.K.Smith, P.Nau, Y.Imai, R.D.Sheldon, E.B.Taylor, D.J.Lerner, A.W.Norris, S.G.Brohawn, R.Kerns, R.Sah. Small Molecule SWELL1-LRRC8 Complex Induction Improves Glycemic Control and Nonalcoholic Fatty Liver Disease in Murine Type 2 Diabetes Biorxiv 2021.
DOI: 10.1101/2021.02.28.432901