Chlorine in PDB 7m20: 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1

Chlorine Binding Sites:

The binding sites of Chlorine atom in the 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1 (pdb code 7m20). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 9 binding sites of Chlorine where determined in the 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1, PDB code: 7m20:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9;

Chlorine binding site 1 out of 9 in 7m20

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Chlorine binding site 1 out of 9 in the 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl501

b:93.2
occ:1.00
 CL1 A:YNP501 0.0 93.2 1.0
C31 A:YNP501 1.8 93.2 1.0
O A:MET313 2.5 160.4 1.0
O A:PRO348 2.7 154.7 1.0
C32 A:YNP501 2.8 93.2 1.0
C30 A:YNP501 2.8 93.2 1.0
SG A:CYS347 2.9 168.6 1.0
O8 A:YNP501 3.0 93.2 1.0
C A:MET313 3.7 160.4 1.0
C A:PRO348 3.9 154.7 1.0
CB A:CYS347 4.0 168.6 1.0
C33 A:YNP501 4.0 93.2 1.0
C29 A:YNP501 4.1 93.2 1.0
C35 A:YNP501 4.4 93.2 1.0
CA A:THR349 4.5 152.3 1.0
C34 A:YNP501 4.5 93.2 1.0
C A:CYS347 4.6 168.6 1.0
CB A:ALA314 4.6 157.3 1.0
CA A:MET313 4.6 160.4 1.0
N A:PRO348 4.7 154.7 1.0
N A:THR349 4.7 152.3 1.0
N A:ALA314 4.7 157.3 1.0
O A:CYS347 4.8 168.6 1.0
CA A:ALA314 4.8 157.3 1.0
CA A:CYS347 4.9 168.6 1.0
CA A:PRO348 4.9 154.7 1.0

Chlorine binding site 2 out of 9 in 7m20

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Chlorine binding site 2 out of 9 in the 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl501

b:93.2
occ:1.00
 CL1 C:YNP501 0.0 93.2 1.0
C31 C:YNP501 1.8 93.2 1.0
O C:MET313 2.6 160.4 1.0
O C:PRO348 2.7 154.7 1.0
C32 C:YNP501 2.8 93.2 1.0
C30 C:YNP501 2.8 93.2 1.0
SG C:CYS347 2.8 168.6 1.0
O8 C:YNP501 3.0 93.2 1.0
C C:MET313 3.8 160.4 1.0
CB C:CYS347 3.9 168.6 1.0
C C:PRO348 3.9 154.7 1.0
C33 C:YNP501 4.0 93.2 1.0
C29 C:YNP501 4.1 93.2 1.0
C35 C:YNP501 4.4 93.2 1.0
C C:CYS347 4.5 168.6 1.0
CA C:THR349 4.5 152.3 1.0
C34 C:YNP501 4.5 93.2 1.0
N C:PRO348 4.6 154.7 1.0
CA C:MET313 4.7 160.4 1.0
N C:THR349 4.7 152.3 1.0
O C:CYS347 4.7 168.6 1.0
CB C:ALA314 4.7 157.3 1.0
CA C:CYS347 4.8 168.6 1.0
N C:ALA314 4.8 157.3 1.0
CA C:PRO348 4.8 154.7 1.0
CA C:ALA314 4.9 157.3 1.0

Chlorine binding site 3 out of 9 in 7m20

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Chlorine binding site 3 out of 9 in the 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Cl501

b:93.2
occ:1.00
 CL1 E:YNP501 0.0 93.2 1.0
C31 E:YNP501 1.8 93.2 1.0
O E:MET313 2.5 160.4 1.0
O E:PRO348 2.7 154.7 1.0
C32 E:YNP501 2.8 93.2 1.0
C30 E:YNP501 2.8 93.2 1.0
SG E:CYS347 2.9 168.6 1.0
O8 E:YNP501 3.0 93.2 1.0
C E:MET313 3.7 160.4 1.0
C E:PRO348 3.9 154.7 1.0
CB E:CYS347 4.0 168.6 1.0
C33 E:YNP501 4.0 93.2 1.0
C29 E:YNP501 4.1 93.2 1.0
C35 E:YNP501 4.4 93.2 1.0
CA E:THR349 4.5 152.3 1.0
C34 E:YNP501 4.5 93.2 1.0
C E:CYS347 4.6 168.6 1.0
CB E:ALA314 4.6 157.3 1.0
CA E:MET313 4.6 160.4 1.0
N E:PRO348 4.7 154.7 1.0
N E:THR349 4.7 152.3 1.0
N E:ALA314 4.7 157.3 1.0
O E:CYS347 4.7 168.6 1.0
CA E:ALA314 4.8 157.3 1.0
CA E:PRO348 4.9 154.7 1.0
CA E:CYS347 4.9 168.6 1.0

Chlorine binding site 4 out of 9 in 7m20

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Chlorine binding site 4 out of 9 in the 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Cl501

b:93.2
occ:1.00
 CL1 G:YNP501 0.0 93.2 1.0
C31 G:YNP501 1.8 93.2 1.0
O G:MET313 2.5 160.4 1.0
O G:PRO348 2.7 154.7 1.0
C32 G:YNP501 2.8 93.2 1.0
C30 G:YNP501 2.8 93.2 1.0
SG G:CYS347 3.0 168.6 1.0
O8 G:YNP501 3.0 93.2 1.0
C G:MET313 3.7 160.4 1.0
C G:PRO348 3.9 154.7 1.0
CB G:CYS347 4.0 168.6 1.0
C33 G:YNP501 4.0 93.2 1.0
C29 G:YNP501 4.1 93.2 1.0
C35 G:YNP501 4.4 93.2 1.0
CA G:THR349 4.5 152.3 1.0
C34 G:YNP501 4.5 93.2 1.0
CB G:ALA314 4.5 157.3 1.0
CA G:MET313 4.6 160.4 1.0
C G:CYS347 4.6 168.6 1.0
N G:ALA314 4.7 157.3 1.0
N G:THR349 4.7 152.3 1.0
N G:PRO348 4.7 154.7 1.0
CA G:ALA314 4.8 157.3 1.0
O G:CYS347 4.8 168.6 1.0
CA G:PRO348 4.9 154.7 1.0
CA G:CYS347 5.0 168.6 1.0

Chlorine binding site 5 out of 9 in 7m20

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Chlorine binding site 5 out of 9 in the 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
I:Cl501

b:93.2
occ:1.00
 CL1 I:YNP501 0.0 93.2 1.0
C31 I:YNP501 1.8 93.2 1.0
O I:MET313 2.6 160.4 1.0
O I:PRO348 2.7 154.7 1.0
C32 I:YNP501 2.8 93.2 1.0
C30 I:YNP501 2.8 93.2 1.0
SG I:CYS347 2.8 168.6 1.0
O8 I:YNP501 3.0 93.2 1.0
C I:MET313 3.8 160.4 1.0
CB I:CYS347 3.9 168.6 1.0
C I:PRO348 3.9 154.7 1.0
C33 I:YNP501 4.0 93.2 1.0
C29 I:YNP501 4.1 93.2 1.0
C35 I:YNP501 4.4 93.2 1.0
C I:CYS347 4.5 168.6 1.0
CA I:THR349 4.5 152.3 1.0
C34 I:YNP501 4.5 93.2 1.0
N I:PRO348 4.6 154.7 1.0
CA I:MET313 4.6 160.4 1.0
CB I:ALA314 4.7 157.3 1.0
N I:THR349 4.7 152.3 1.0
O I:CYS347 4.7 168.6 1.0
N I:ALA314 4.8 157.3 1.0
CA I:CYS347 4.8 168.6 1.0
CA I:PRO348 4.9 154.7 1.0
CA I:ALA314 4.9 157.3 1.0

Chlorine binding site 6 out of 9 in 7m20

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Chlorine binding site 6 out of 9 in the 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
K:Cl501

b:93.2
occ:1.00
 CL1 K:YNP501 0.0 93.2 1.0
C31 K:YNP501 1.8 93.2 1.0
O K:MET313 2.6 160.4 1.0
O K:PRO348 2.6 154.7 1.0
C32 K:YNP501 2.8 93.2 1.0
C30 K:YNP501 2.8 93.2 1.0
SG K:CYS347 2.9 168.6 1.0
O8 K:YNP501 3.0 93.2 1.0
C K:PRO348 3.8 154.7 1.0
C K:MET313 3.8 160.4 1.0
CB K:CYS347 3.9 168.6 1.0
C33 K:YNP501 4.0 93.2 1.0
C29 K:YNP501 4.1 93.2 1.0
C35 K:YNP501 4.4 93.2 1.0
CA K:THR349 4.4 152.3 1.0
C K:CYS347 4.5 168.6 1.0
C34 K:YNP501 4.5 93.2 1.0
N K:PRO348 4.6 154.7 1.0
N K:THR349 4.6 152.3 1.0
CB K:ALA314 4.7 157.3 1.0
O K:CYS347 4.7 168.6 1.0
CA K:MET313 4.7 160.4 1.0
N K:ALA314 4.8 157.3 1.0
CA K:PRO348 4.8 154.7 1.0
CA K:CYS347 4.8 168.6 1.0
CA K:ALA314 4.9 157.3 1.0

Chlorine binding site 7 out of 9 in 7m20

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Chlorine binding site 7 out of 9 in the 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
M:Cl501

b:93.2
occ:1.00
 CL1 M:YNP501 0.0 93.2 1.0
C31 M:YNP501 1.8 93.2 1.0
O M:MET313 2.5 160.4 1.0
O M:PRO348 2.8 154.7 1.0
C32 M:YNP501 2.8 93.2 1.0
C30 M:YNP501 2.8 93.2 1.0
SG M:CYS347 2.9 168.6 1.0
O8 M:YNP501 3.0 93.2 1.0
C M:MET313 3.7 160.4 1.0
C M:PRO348 3.9 154.7 1.0
CB M:CYS347 4.0 168.6 1.0
C33 M:YNP501 4.0 93.2 1.0
C29 M:YNP501 4.1 93.2 1.0
C35 M:YNP501 4.4 93.2 1.0
CA M:THR349 4.5 152.3 1.0
C34 M:YNP501 4.5 93.2 1.0
C M:CYS347 4.6 168.6 1.0
CA M:MET313 4.6 160.4 1.0
CB M:ALA314 4.6 157.3 1.0
N M:PRO348 4.7 154.7 1.0
N M:THR349 4.7 152.3 1.0
N M:ALA314 4.7 157.3 1.0
O M:CYS347 4.8 168.6 1.0
CA M:ALA314 4.8 157.3 1.0
CA M:CYS347 4.9 168.6 1.0
CA M:PRO348 4.9 154.7 1.0

Chlorine binding site 8 out of 9 in 7m20

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Chlorine binding site 8 out of 9 in the 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
O:Cl501

b:93.2
occ:1.00
 CL1 O:YNP501 0.0 93.2 1.0
C31 O:YNP501 1.8 93.2 1.0
O O:MET313 2.5 160.4 1.0
C32 O:YNP501 2.8 93.2 1.0
C30 O:YNP501 2.8 93.2 1.0
O O:PRO348 2.8 154.7 1.0
SG O:CYS347 2.8 168.6 1.0
O8 O:YNP501 3.0 93.2 1.0
C O:MET313 3.8 160.4 1.0
CB O:CYS347 3.9 168.6 1.0
C O:PRO348 4.0 154.7 1.0
C33 O:YNP501 4.0 93.2 1.0
C29 O:YNP501 4.1 93.2 1.0
C35 O:YNP501 4.4 93.2 1.0
C34 O:YNP501 4.5 93.2 1.0
C O:CYS347 4.5 168.6 1.0
CA O:MET313 4.6 160.4 1.0
CA O:THR349 4.6 152.3 1.0
N O:PRO348 4.6 154.7 1.0
CB O:ALA314 4.6 157.3 1.0
O O:CYS347 4.7 168.6 1.0
N O:ALA314 4.7 157.3 1.0
N O:THR349 4.7 152.3 1.0
CA O:CYS347 4.8 168.6 1.0
CA O:ALA314 4.9 157.3 1.0
CA O:PRO348 4.9 154.7 1.0

Chlorine binding site 9 out of 9 in 7m20

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Chlorine binding site 9 out of 9 in the 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of 18-Mer Hela-Tubulin Rings in Complex with Cryptophycin 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
Q:Cl501

b:93.2
occ:1.00
 CL1 Q:YNP501 0.0 93.2 1.0
C31 Q:YNP501 1.8 93.2 1.0
O Q:MET313 2.5 160.4 1.0
C32 Q:YNP501 2.8 93.2 1.0
C30 Q:YNP501 2.8 93.2 1.0
O Q:PRO348 2.8 154.7 1.0
SG Q:CYS347 2.9 168.6 1.0
O8 Q:YNP501 3.0 93.2 1.0
C Q:MET313 3.7 160.4 1.0
C Q:PRO348 3.9 154.7 1.0
CB Q:CYS347 3.9 168.6 1.0
C33 Q:YNP501 4.0 93.2 1.0
C29 Q:YNP501 4.1 93.2 1.0
C35 Q:YNP501 4.4 93.2 1.0
CA Q:THR349 4.5 152.3 1.0
C34 Q:YNP501 4.5 93.2 1.0
CA Q:MET313 4.6 160.4 1.0
C Q:CYS347 4.6 168.6 1.0
CB Q:ALA314 4.6 157.3 1.0
N Q:PRO348 4.7 154.7 1.0
N Q:ALA314 4.7 157.3 1.0
N Q:THR349 4.7 152.3 1.0
O Q:CYS347 4.7 168.6 1.0
CA Q:ALA314 4.8 157.3 1.0
CA Q:CYS347 4.9 168.6 1.0
CA Q:PRO348 4.9 154.7 1.0

Reference:

E.Eren, N.R.Watts, D.L.Sackett, P.T.Wingfield. Conformational Changes in Tubulin Upon Binding Cryptophycin-52 Reveal Its Mechanism of Action J.Biol.Chem. 2021.
ISSN: ESSN 1083-351X
DOI: 10.1016/J.JBC.2021.101138
Page generated: Tue Jul 30 00:22:15 2024

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