Chlorine in PDB 7n3n: Cryo-Em Structure of Human NKCC1 State Fu-I

The binding sites of Chlorine atom in the Cryo-Em Structure of Human NKCC1 State Fu-I (pdb code 7n3n). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Cryo-Em Structure of Human NKCC1 State Fu-I, PDB code: 7n3n:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Cryo-Em Structure of Human NKCC1 State Fu-I


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of Human NKCC1 State Fu-I within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1301 b:40.6 occ:1.00 CL1 A:FUN1301 0.0 40.6 1.0 C2 A:FUN1301 1.8 40.6 1.0 C3 A:FUN1301 2.8 40.6 1.0 C1 A:FUN1301 2.8 40.6 1.0 O1 A:FUN1301 3.2 40.6 1.0 S1 A:FUN1301 3.2 40.6 1.0 N1 A:FUN1301 3.4 40.6 1.0 CE1 A:TYR903 3.6 10.0 1.0 CD1 A:TYR903 3.7 10.0 1.0 O A:MET794 3.9 10.6 1.0 CD2 A:LEU886 4.0 32.5 1.0 C11 A:FUN1301 4.0 40.6 1.0 C4 A:FUN1301 4.0 40.6 1.0 CD2 A:LEU863 4.4 14.9 1.0 C10 A:FUN1301 4.6 40.6 1.0 O2 A:FUN1301 4.6 40.6 1.0 O A:GLY887 4.9 9.5 1.0 CZ A:TYR903 4.9 10.0 1.0 CB A:LEU886 4.9 32.5 1.0 CD1 A:LEU863 5.0 14.9 1.0 CG A:LEU886 5.0 32.5 1.0

Chlorine binding site 2 out of 2 in the Cryo-Em Structure of Human NKCC1 State Fu-I


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of Human NKCC1 State Fu-I within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1301 b:41.1 occ:1.00 CL1 B:FUN1301 0.0 41.1 1.0 C2 B:FUN1301 1.8 41.1 1.0 C3 B:FUN1301 2.7 41.1 1.0 C1 B:FUN1301 2.8 41.1 1.0 O1 B:FUN1301 3.1 41.1 1.0 S1 B:FUN1301 3.2 41.1 1.0 CD2 B:LEU886 3.5 0.5 1.0 CD2 B:LEU863 3.5 12.8 1.0 N1 B:FUN1301 3.6 41.1 1.0 CD1 B:LEU906 3.9 8.4 1.0 O B:MET794 4.0 8.8 1.0 C4 B:FUN1301 4.0 41.1 1.0 C11 B:FUN1301 4.0 41.1 1.0 CD1 B:TYR903 4.2 8.6 1.0 CB B:MET794 4.3 8.8 1.0 CD1 B:LEU863 4.3 12.8 1.0 CG B:LEU863 4.4 12.8 1.0 CE1 B:TYR903 4.5 8.6 1.0 C10 B:FUN1301 4.6 41.1 1.0 O2 B:FUN1301 4.6 41.1 1.0 C B:MET794 4.9 8.8 1.0 CG B:LEU886 5.0 0.5 1.0 CE B:MET794 5.0 8.8 1.0

M.A.Moseng, C.C.Su, K.Rios, M.Cui, M.Lyu, P.Glaza, P.A.Klenotic, E.Delpire, E.W.Yu. Inhibition Mechanism of NKCC1 Involves the Carboxyl Terminus and Long-Range Conformational Coupling. Sci Adv V. 8 Q0952 2022.
ISSN: ESSN 2375-2548
PubMed: 36306358
DOI: 10.1126/SCIADV.ABQ0952