Chlorine in PDB 7n86: Crystal Structure of Human Protocadherin-24 EC1-2 Form II

The structure of Crystal Structure of Human Protocadherin-24 EC1-2 Form II, PDB code: 7n86 was solved by D.Modak, M.E.Gray, M.Sotomayor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.15 / 3.18
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	63.899, 86.641, 104.892, 90, 103.46, 90
R / Rfree (%)	21.4 / 29

The structure of Crystal Structure of Human Protocadherin-24 EC1-2 Form II also contains other interesting chemical elements:

Sodium	(Na)	2 atoms
Calcium	(Ca)	14 atoms
Iodine	(I)	1 atom

The binding sites of Chlorine atom in the Crystal Structure of Human Protocadherin-24 EC1-2 Form II (pdb code 7n86). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Crystal Structure of Human Protocadherin-24 EC1-2 Form II, PDB code: 7n86:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;

Chlorine binding site 1 out of 6 in the Crystal Structure of Human Protocadherin-24 EC1-2 Form II


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Protocadherin-24 EC1-2 Form II within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl305 b:12.4 occ:1.00 N A:PHE104 3.7 38.4 1.0 N A:LEU203 4.0 69.5 1.0 CA A:VAL103 4.0 35.4 1.0 CB A:LEU203 4.2 64.2 1.0 CB A:SER202 4.3 69.3 1.0 O A:PRO102 4.3 30.2 1.0 C A:VAL103 4.4 35.6 1.0 CD1 A:PHE104 4.5 26.2 1.0 O A:LEU203 4.6 51.1 1.0 CB A:PHE104 4.7 37.0 1.0 CA A:LEU203 4.7 65.1 1.0 CG1 A:VAL103 4.7 44.2 1.0 CA A:PHE104 4.7 42.7 1.0 OG A:SER202 4.8 78.8 1.0 O A:PHE104 4.8 52.6 1.0 CB A:VAL103 4.8 36.2 1.0 CG A:LEU203 4.8 60.1 1.0 CG2 A:THR107 4.8 56.4 1.0 CA A:SER202 4.8 62.0 1.0 CD1 A:LEU203 4.9 56.2 1.0 C A:SER202 4.9 61.5 1.0 CG2 A:VAL103 5.0 32.6 1.0

Chlorine binding site 2 out of 6 in the Crystal Structure of Human Protocadherin-24 EC1-2 Form II


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Protocadherin-24 EC1-2 Form II within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl305 b:6.0 occ:1.00 OG1 B:THR76 3.3 46.7 1.0 CD B:PRO45 3.8 41.4 1.0 CG1 A:VAL129 4.0 28.4 1.0 NE2 A:GLN105 4.0 124.8 1.0 CA B:GLY44 4.1 34.7 1.0 O B:LYS74 4.2 41.6 1.0 CB A:VAL129 4.2 23.4 1.0 N B:THR76 4.2 30.2 1.0 CG2 A:VAL129 4.3 21.2 1.0 CG B:PRO45 4.3 44.6 1.0 CA B:VAL75 4.4 25.2 1.0 C B:VAL75 4.4 25.8 1.0 O B:SER43 4.5 51.4 1.0 CB B:THR76 4.5 36.6 1.0 C B:LYS74 4.6 29.1 1.0 N B:PRO45 4.6 38.8 1.0 C B:GLY44 4.7 33.3 1.0 N B:VAL75 4.7 26.7 1.0 CA B:THR76 4.9 36.8 1.0

Chlorine binding site 3 out of 6 in the Crystal Structure of Human Protocadherin-24 EC1-2 Form II


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Human Protocadherin-24 EC1-2 Form II within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl305 b:46.3 occ:1.00 N A:PHE197 3.5 44.1 1.0 N C:PHE197 3.5 36.2 1.0 CA C:THR196 4.0 40.8 1.0 OG1 A:THR196 4.0 71.2 1.0 CA A:THR196 4.0 55.4 1.0 CB A:PHE197 4.1 52.7 1.0 C A:THR196 4.3 52.5 1.0 CB C:PHE197 4.3 34.0 1.0 C C:THR196 4.3 32.7 1.0 CG2 C:THR196 4.4 41.3 1.0 CA A:PHE197 4.4 45.5 1.0 O C:ASN195 4.5 79.9 1.0 CA C:PHE197 4.5 34.8 1.0 CB A:THR196 4.6 58.4 1.0 O A:ASN195 4.6 42.9 1.0 CB C:THR196 4.7 41.0 1.0 N C:THR196 5.0 48.8 1.0

Chlorine binding site 4 out of 6 in the Crystal Structure of Human Protocadherin-24 EC1-2 Form II


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Human Protocadherin-24 EC1-2 Form II within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl306 b:14.9 occ:1.00 CG2 D:VAL129 3.6 25.0 1.0 OG1 C:THR76 3.7 52.7 1.0 CD C:PRO45 3.7 37.9 1.0 N C:THR76 4.1 52.6 1.0 C C:VAL75 4.2 41.8 1.0 CA C:GLY44 4.3 33.4 1.0 O C:LYS74 4.3 38.3 1.0 CA C:VAL75 4.3 35.5 1.0 O C:SER43 4.4 36.2 1.0 CB C:THR76 4.5 53.3 1.0 C C:LYS74 4.6 31.1 1.0 CB D:VAL129 4.6 21.2 1.0 N C:PRO45 4.7 38.2 1.0 O C:VAL75 4.7 40.0 1.0 N C:VAL75 4.7 31.3 1.0 CG C:PRO45 4.8 40.6 1.0 CA C:THR76 4.8 50.5 1.0 C C:GLY44 4.9 34.2 1.0 CB C:LYS74 5.0 24.9 1.0

Chlorine binding site 5 out of 6 in the Crystal Structure of Human Protocadherin-24 EC1-2 Form II


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of Human Protocadherin-24 EC1-2 Form II within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl307 b:1.6 occ:1.00 CD D:PRO45 4.2 31.5 1.0 CG D:PRO45 4.3 28.6 1.0 CG1 C:VAL129 4.3 31.5 1.0 CA C:LYS131 4.4 34.9 1.0 CG C:LYS131 4.5 52.6 1.0 CB C:LYS131 4.6 41.8 1.0 O D:LYS74 4.6 25.4 1.0 CB D:LYS74 4.8 23.7 1.0 CB D:PRO45 4.9 27.4 1.0 N C:LYS131 4.9 34.0 1.0 CE C:LYS131 5.0 60.7 1.0 CD C:LYS131 5.0 54.5 1.0

Chlorine binding site 6 out of 6 in the Crystal Structure of Human Protocadherin-24 EC1-2 Form II


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Crystal Structure of Human Protocadherin-24 EC1-2 Form II within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl305 b:13.4 occ:1.00 N D:PHE104 3.8 43.5 1.0 CA D:VAL103 3.8 36.7 1.0 N D:LEU203 4.1 56.2 1.0 C D:VAL103 4.3 39.5 1.0 CG2 D:VAL103 4.4 37.3 1.0 O D:PRO102 4.4 22.1 1.0 CB D:LEU203 4.4 69.0 1.0 CB D:SER202 4.4 45.2 1.0 CB D:VAL103 4.4 38.2 1.0 CD1 D:PHE104 4.5 32.2 1.0 CG1 D:VAL103 4.6 40.2 1.0 O D:LEU203 4.6 43.5 1.0 CB D:PHE104 4.7 38.9 1.0 CA D:LEU203 4.8 54.6 1.0 N D:VAL103 4.9 30.4 1.0 CA D:SER202 4.9 43.6 1.0 CA D:PHE104 4.9 43.0 1.0 OG D:SER202 5.0 49.8 1.0 C D:SER202 5.0 51.6 1.0

M.E.Gray, Z.R.Johnson, D.Modak, T.J.Tyska, M.Sotomayor. Species-Dependent Heterophilic and Homophilic Cadherin Interactions in Intestinal Intermicrovillar Links To Be Published.