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Chlorine in PDB 7na4: HDM2 in Complex with Compound 63Enzymatic activity of HDM2 in Complex with Compound 63
All present enzymatic activity of HDM2 in Complex with Compound 63:
2.3.2.27; Protein crystallography data
The structure of HDM2 in Complex with Compound 63, PDB code: 7na4
was solved by
G.Scapin,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the HDM2 in Complex with Compound 63
(pdb code 7na4). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the HDM2 in Complex with Compound 63, PDB code: 7na4: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 7na4Go back to Chlorine Binding Sites List in 7na4
Chlorine binding site 1 out
of 2 in the HDM2 in Complex with Compound 63
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 7na4Go back to Chlorine Binding Sites List in 7na4
Chlorine binding site 2 out
of 2 in the HDM2 in Complex with Compound 63
Mono view Stereo pair view
Reference:
M.H.Reutershan,
M.R.Machacek,
M.D.Altman,
S.Bogen,
M.Cai,
C.Cammarano,
D.Chen,
M.Christopher,
J.Cryan,
P.Daublain,
X.Fradera,
P.Geda,
P.Goldenblatt,
A.D.Hill,
R.A.Kemper,
V.Kutilek,
C.Li,
M.Martinez,
M.Mccoy,
L.Nair,
W.Pan,
C.F.Thompson,
G.Scapin,
M.Shizuka,
M.L.Spatz,
D.Steinhuebel,
B.Sun,
M.E.Voss,
X.Wang,
L.Yang,
T.C.Yeh,
I.Dussault,
C.G.Marshall,
B.W.Trotter.
Discovery of Mk-4688 : An Efficient Inhibitor of the HDM2-P53 Protein-Protein Interaction. J.Med.Chem. 2021.
Page generated: Thu Nov 25 08:54:58 2021
ISSN: ISSN 0022-2623 PubMed: 34714078 DOI: 10.1021/ACS.JMEDCHEM.1C01524 |
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