Chlorine in PDB 7nja: 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound LVD1006

All present enzymatic activity of 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound LVD1006:
5.2.1.8;

The structure of 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound LVD1006, PDB code: 7nja was solved by M.Wolter, L.V.Dijck, P.J.Cossar, C.Ottmann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	25.58 / 1.75
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	82.4, 112.101, 62.622, 90, 90, 90
R / Rfree (%)	22 / 26.5

The binding sites of Chlorine atom in the 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound LVD1006 (pdb code 7nja). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound LVD1006, PDB code: 7nja:

Chlorine binding site 1 out of 1 in the 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound LVD1006


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound LVD1006 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl302 b:15.0 occ:0.89 NZ A:LYS9 3.2 11.8 1.0 CD A:LYS9 3.7 9.8 1.0 CE A:LYS9 3.9 10.3 1.0 CZ A:PHE25 4.3 7.6 1.0 CE1 A:PHE25 4.5 6.2 1.0 CE A:MET1 4.6 7.3 1.0

P.J.Cossar, M.Wolter, L.Van Dijck, D.Valenti, L.M.Levy, C.Ottmann, L.Brunsveld. Reversible Covalent Imine-Tethering For Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc. 2021.
ISSN: ESSN 1520-5126
PubMed: 34047554
DOI: 10.1021/JACS.1C03035