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Chlorine in PDB 7nqo: Mycobacterium Tuberculosis Cytochrome P450 CYP121 in Complex with Lead Compound 21Enzymatic activity of Mycobacterium Tuberculosis Cytochrome P450 CYP121 in Complex with Lead Compound 21
All present enzymatic activity of Mycobacterium Tuberculosis Cytochrome P450 CYP121 in Complex with Lead Compound 21:
1.14.19.70; Protein crystallography data
The structure of Mycobacterium Tuberculosis Cytochrome P450 CYP121 in Complex with Lead Compound 21, PDB code: 7nqo
was solved by
I.R.Selvam,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7nqo:
The structure of Mycobacterium Tuberculosis Cytochrome P450 CYP121 in Complex with Lead Compound 21 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Mycobacterium Tuberculosis Cytochrome P450 CYP121 in Complex with Lead Compound 21
(pdb code 7nqo). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Mycobacterium Tuberculosis Cytochrome P450 CYP121 in Complex with Lead Compound 21, PDB code: 7nqo: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 7nqoGo back to Chlorine Binding Sites List in 7nqo
Chlorine binding site 1 out
of 2 in the Mycobacterium Tuberculosis Cytochrome P450 CYP121 in Complex with Lead Compound 21
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 7nqoGo back to Chlorine Binding Sites List in 7nqo
Chlorine binding site 2 out
of 2 in the Mycobacterium Tuberculosis Cytochrome P450 CYP121 in Complex with Lead Compound 21
Mono view Stereo pair view
Reference:
M.Frederickson,
I.R.Selvam,
D.Evangelopoulos,
K.J.Mclean,
M.M.Katariya,
R.B.Tunnicliffe,
B.Campbell,
M.E.Kavanagh,
S.Charoensutthivarakul,
R.T.Blankley,
C.W.Levy,
L.P.S.De Carvalho,
D.Leys,
A.W.Munro,
A.G.Coyne,
C.Abell.
A New Strategy For Hit Generation: Novel in Cellulo Active Inhibitors of CYP121A1 From Mycobacterium Tuberculosis Via A Combined X-Ray Crystallographic and Phenotypic Screening Approach (Xp Screen). Eur.J.Med.Chem. V. 230 14105 2022.
Page generated: Tue Apr 4 20:55:13 2023
ISSN: ISSN 0223-5234 PubMed: 35065413 DOI: 10.1016/J.EJMECH.2022.114105 |
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