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Atomistry » Chlorine » PDB 7nq6-7nxy » 7nxk | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 7nq6-7nxy » 7nxk » |
Chlorine in PDB 7nxk: Crystal Structure of Human CDK12/Cyclin K in Complex with the Inhibitor Bsj-01-175Enzymatic activity of Crystal Structure of Human CDK12/Cyclin K in Complex with the Inhibitor Bsj-01-175
All present enzymatic activity of Crystal Structure of Human CDK12/Cyclin K in Complex with the Inhibitor Bsj-01-175:
2.7.11.22; 2.7.11.23; Protein crystallography data
The structure of Crystal Structure of Human CDK12/Cyclin K in Complex with the Inhibitor Bsj-01-175, PDB code: 7nxk
was solved by
K.Anand,
S.Dust,
I.H.Kaltheuner,
M.Geyer,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human CDK12/Cyclin K in Complex with the Inhibitor Bsj-01-175
(pdb code 7nxk). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human CDK12/Cyclin K in Complex with the Inhibitor Bsj-01-175, PDB code: 7nxk: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 7nxkGo back to![]() ![]()
Chlorine binding site 1 out
of 2 in the Crystal Structure of Human CDK12/Cyclin K in Complex with the Inhibitor Bsj-01-175
![]() Mono view ![]() Stereo pair view
Chlorine binding site 2 out of 2 in 7nxkGo back to![]() ![]()
Chlorine binding site 2 out
of 2 in the Crystal Structure of Human CDK12/Cyclin K in Complex with the Inhibitor Bsj-01-175
![]() Mono view ![]() Stereo pair view
Reference:
B.Jiang,
J.Jiang,
I.H.Kaltheuner,
A.B.Iniguez,
K.Anand,
F.M.Ferguson,
S.B.Ficarro,
B.K.A.Seong,
A.K.Greifenberg,
S.Dust,
N.P.Kwiatkowski,
J.A.Marto,
K.Stegmaier,
T.Zhang,
M.Geyer,
N.S.Gray.
Structure-Activity Relationship Study of THZ531 Derivatives Enables the Discovery of Bsj-01-175 As A Dual CDK12/13 Covalent Inhibitor with Efficacy in Ewing Sarcoma. Eur.J.Med.Chem. V. 221 13481 2021.
Page generated: Tue Jul 30 01:08:59 2024
ISSN: ISSN 0223-5234 PubMed: 33945934 DOI: 10.1016/J.EJMECH.2021.113481 |
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