Chlorine in PDB 7o4g: Human Phosphomannomutase 2 (PMM2) Wild-Type Soaked with the Activator Glucose 1,6-Bisphosphate

Enzymatic activity of Human Phosphomannomutase 2 (PMM2) Wild-Type Soaked with the Activator Glucose 1,6-Bisphosphate

All present enzymatic activity of Human Phosphomannomutase 2 (PMM2) Wild-Type Soaked with the Activator Glucose 1,6-Bisphosphate:
5.4.2.8;

Protein crystallography data

The structure of Human Phosphomannomutase 2 (PMM2) Wild-Type Soaked with the Activator Glucose 1,6-Bisphosphate, PDB code: 7o4g was solved by S.Ramon-Maiques, A.Briso-Montiano, F.Del Cano-Ochoa, A.Vilas, B.Perez, V.Rubio, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 60.21 / 2.66
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 71.144, 71.144, 361.266, 90, 90, 120
R / Rfree (%) 22.4 / 27.3

Other elements in 7o4g:

The structure of Human Phosphomannomutase 2 (PMM2) Wild-Type Soaked with the Activator Glucose 1,6-Bisphosphate also contains other interesting chemical elements:

Sodium (Na) 1 atom
Magnesium (Mg) 4 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Human Phosphomannomutase 2 (PMM2) Wild-Type Soaked with the Activator Glucose 1,6-Bisphosphate (pdb code 7o4g). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human Phosphomannomutase 2 (PMM2) Wild-Type Soaked with the Activator Glucose 1,6-Bisphosphate, PDB code: 7o4g:

Chlorine binding site 1 out of 1 in 7o4g

Go back to Chlorine Binding Sites List in 7o4g
Chlorine binding site 1 out of 1 in the Human Phosphomannomutase 2 (PMM2) Wild-Type Soaked with the Activator Glucose 1,6-Bisphosphate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Phosphomannomutase 2 (PMM2) Wild-Type Soaked with the Activator Glucose 1,6-Bisphosphate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl304

b:33.2
occ:1.00
 H B:PHE119 2.2 47.2 1.0
H A:PHE119 2.4 41.5 1.0
H A:ILE120 2.6 32.3 1.0
H B:ILE120 2.8 42.6 1.0
HA B:THR118 2.9 55.3 1.0
N B:PHE119 2.9 38.4 1.0
HD2 B:PHE119 3.0 44.5 1.0
HA A:THR118 3.1 39.5 1.0
N A:PHE119 3.1 33.6 1.0
HB2 B:PHE119 3.2 40.6 1.0
HB2 A:PHE119 3.2 41.0 1.0
HD2 A:PHE119 3.3 40.5 1.0
N A:ILE120 3.4 26.0 1.0
H B:THR118 3.5 44.7 1.0
CA B:THR118 3.5 45.1 1.0
N B:ILE120 3.6 34.5 1.0
HD12 A:ILE120 3.6 60.0 1.0
C B:THR118 3.6 40.2 1.0
CA B:PHE119 3.8 36.2 1.0
CA A:THR118 3.8 32.0 1.0
HB A:ILE120 3.8 42.4 1.0
CD2 B:PHE119 3.8 36.1 1.0
H A:THR118 3.8 48.6 1.0
CB B:PHE119 3.8 32.9 1.0
N B:THR118 3.9 36.3 1.0
CA A:PHE119 3.9 29.0 1.0
C A:THR118 3.9 30.9 1.0
CB A:PHE119 3.9 33.2 1.0
CD2 A:PHE119 4.1 32.8 1.0
O A:ILE120 4.1 43.3 1.0
HB B:ILE120 4.1 50.3 1.0
C A:PHE119 4.1 30.7 1.0
N A:THR118 4.1 39.5 1.0
C B:PHE119 4.1 37.3 1.0
HG12 B:ILE120 4.3 49.5 1.0
CG B:PHE119 4.3 36.2 1.0
O B:ILE120 4.4 37.9 1.0
CA A:ILE120 4.4 28.4 1.0
CD1 A:ILE120 4.4 49.0 1.0
HD21 A:LEU104 4.5 45.4 1.0
CG A:PHE119 4.5 25.3 1.0
CB A:ILE120 4.5 34.4 1.0
HD21 B:LEU104 4.5 48.5 1.0
HD13 A:ILE120 4.5 60.0 1.0
CA B:ILE120 4.6 34.4 1.0
HA B:PHE119 4.6 44.6 1.0
HB3 B:PHE119 4.7 40.6 1.0
C A:ILE120 4.7 27.6 1.0
CB B:ILE120 4.7 41.0 1.0
HB3 A:PHE119 4.7 41.0 1.0
HG23 B:THR118 4.7 44.4 1.0
HA A:PHE119 4.8 35.9 1.0
HG23 A:THR118 4.8 38.9 1.0
O B:THR118 4.8 33.6 1.0
HD23 A:LEU104 4.9 45.4 1.0
CE2 B:PHE119 4.9 34.7 1.0
CB B:THR118 4.9 43.4 1.0
C B:ILE120 4.9 37.7 1.0
CG1 B:ILE120 4.9 40.3 1.0
HE2 B:PHE119 5.0 42.8 1.0
C B:GLY117 5.0 36.8 1.0
CG1 A:ILE120 5.0 35.9 1.0

Reference:

A.Briso-Montiano, F.Del Cano-Ochoa, A.Vilas, A.Velazquez-Campoy, V.Rubio, B.Perez, S.Ramon-Maiques. Insight on Molecular Pathogenesis and Pharmacochaperoning Potential in Phosphomannomutase 2 Deficiency, Provided By Novel Human Phosphomannomutase 2 Structures. J Inherit Metab Dis V. 45 318 2022.
ISSN: ISSN 1573-2665
PubMed: 34859900
DOI: 10.1002/JIMD.12461
Page generated: Tue Jul 30 01:14:16 2024

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