Chlorine in PDB 7o65: Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site

Enzymatic activity of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site

All present enzymatic activity of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site:
1.16.3.1;

Protein crystallography data

The structure of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site, PDB code: 7o65 was solved by C.Pozzi, S.Ciambellotti, G.Tassone, P.Turano, S.Mangani, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 65.23 / 1.70
Space group F 4 3 2
Cell size a, b, c (Å), α, β, γ (°) 184.271, 184.271, 184.271, 90, 90, 90
R / Rfree (%) 15.5 / 18.1

Other elements in 7o65:

The structure of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site also contains other interesting chemical elements:

Iron (Fe) 10 atoms
Magnesium (Mg) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site (pdb code 7o65). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site, PDB code: 7o65:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 7o65

Go back to Chlorine Binding Sites List in 7o65
Chlorine binding site 1 out of 4 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl212

b:21.4
occ:0.25
 FE A:FE2201 2.4 20.1 0.2
CE1 A:HIS173 3.2 25.3 0.6
NE2 A:HIS173 3.2 15.1 0.4
NE2 A:HIS173 3.4 21.9 0.6
CE1 A:HIS173 3.4 15.5 0.4
CD2 A:LEU169 3.8 18.7 1.0
CD2 A:HIS173 4.3 15.2 0.4
ND1 A:HIS173 4.4 23.9 0.6
ND1 A:HIS173 4.5 15.0 0.4
O A:HOH480 4.6 18.5 0.2
CD2 A:HIS173 4.7 22.8 0.6
CG A:HIS173 4.9 15.2 0.4

Chlorine binding site 2 out of 4 in 7o65

Go back to Chlorine Binding Sites List in 7o65
Chlorine binding site 2 out of 4 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl213

b:24.5
occ:1.00
 O A:HOH321 2.9 39.0 1.0
ND1 A:HIS151 2.9 16.3 1.0
ND2 A:ASN154 3.3 18.5 1.0
C A:ASP150 3.5 14.5 1.0
O A:ASP150 3.6 15.3 1.0
N A:HIS151 3.6 14.1 1.0
CE1 A:HIS151 3.7 16.2 1.0
CB A:ASP150 3.7 14.8 1.0
CA A:HIS151 3.7 13.3 1.0
CG2 A:THR174 3.9 18.6 0.6
CG A:HIS151 4.1 14.7 1.0
CE1 A:PHE170 4.1 16.1 1.0
CG2 A:THR174 4.1 15.3 0.4
O A:HOH391 4.1 37.7 1.0
CG A:ASN154 4.2 16.9 1.0
CA A:ASP150 4.3 14.8 1.0
CZ A:PHE170 4.3 16.3 1.0
CB A:ASN154 4.4 15.7 1.0
CB A:HIS151 4.5 13.6 1.0
OG1 A:THR174 4.8 14.8 0.4
OG1 A:THR174 4.9 17.4 0.6
C A:HIS151 4.9 13.7 1.0
CG A:ASP150 4.9 17.6 1.0
NE2 A:HIS151 4.9 17.8 1.0

Chlorine binding site 3 out of 4 in 7o65

Go back to Chlorine Binding Sites List in 7o65
Chlorine binding site 3 out of 4 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl214

b:35.9
occ:0.70
 ND1 A:HIS153 3.1 16.5 1.0
CE1 A:HIS153 3.9 18.1 1.0
CG A:HIS153 4.1 14.3 1.0
O A:HOH563 4.1 38.5 1.0
CA A:HIS153 4.1 15.4 1.0
CB A:HIS153 4.2 14.5 1.0
CG1 A:VAL156 4.5 17.9 1.0
CB A:VAL156 4.6 14.6 1.0
O A:HIS153 4.7 14.3 1.0
O A:HOH581 4.9 31.8 0.5
C A:HIS153 4.9 14.1 1.0

Chlorine binding site 4 out of 4 in 7o65

Go back to Chlorine Binding Sites List in 7o65
Chlorine binding site 4 out of 4 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl215

b:21.0
occ:0.70
 O A:HOH506 3.1 32.8 0.5
N A:PHE12 3.2 15.2 1.0
O A:HOH505 3.3 33.1 1.0
N A:ASN11 3.4 14.9 1.0
O A:PHE12 3.5 16.2 1.0
CG A:ARG9 3.6 15.8 1.0
NE A:ARG9 3.6 16.3 1.0
CD A:ARG9 3.7 16.2 1.0
O A:HOH465 3.7 34.5 1.0
C A:GLN10 3.9 15.4 1.0
O A:HOH538 3.9 35.8 1.0
CA A:GLN10 4.0 15.0 1.0
C A:PHE12 4.0 16.0 1.0
CA A:PHE12 4.0 15.6 1.0
N A:GLN10 4.1 13.7 1.0
CA A:ASN11 4.1 15.2 1.0
C A:ASN11 4.1 14.0 1.0
CB A:PHE12 4.3 15.8 1.0
C A:ARG9 4.4 14.9 1.0
CB A:ARG9 4.6 14.2 1.0
O A:ARG9 4.6 16.2 1.0
O A:GLN10 4.7 14.7 1.0
CZ A:ARG9 4.9 17.5 1.0

Reference:

S.Ciambellotti, A.Pratesi, G.Tassone, P.Turano, S.Mangani, C.Pozzi. Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin. Chemistry 2021.
ISSN: ISSN 0947-6539
PubMed: 34343376
DOI: 10.1002/CHEM.202102270
Page generated: Tue Jul 30 01:16:42 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy