Chlorine in PDB 7o65: Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site

Enzymatic activity of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site

All present enzymatic activity of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site:
1.16.3.1;

Protein crystallography data

The structure of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site, PDB code: 7o65 was solved by C.Pozzi, S.Ciambellotti, G.Tassone, P.Turano, S.Mangani, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 65.23 / 1.70
Space group F 4 3 2
Cell size a, b, c (Å), α, β, γ (°) 184.271, 184.271, 184.271, 90, 90, 90
R / Rfree (%) 15.5 / 18.1

Other elements in 7o65:

The structure of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site also contains other interesting chemical elements:

Iron (Fe) 10 atoms
Magnesium (Mg) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site (pdb code 7o65). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site, PDB code: 7o65:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 7o65

Go back to Chlorine Binding Sites List in 7o65
Chlorine binding site 1 out of 4 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl212

b:21.4
occ:0.25
 FE A:FE2201 2.4 20.1 0.2
CE1 A:HIS173 3.2 25.3 0.6
NE2 A:HIS173 3.2 15.1 0.4
NE2 A:HIS173 3.4 21.9 0.6
CE1 A:HIS173 3.4 15.5 0.4
CD2 A:LEU169 3.8 18.7 1.0
CD2 A:HIS173 4.3 15.2 0.4
ND1 A:HIS173 4.4 23.9 0.6
ND1 A:HIS173 4.5 15.0 0.4
O A:HOH480 4.6 18.5 0.2
CD2 A:HIS173 4.7 22.8 0.6
CG A:HIS173 4.9 15.2 0.4

Chlorine binding site 2 out of 4 in 7o65

Go back to Chlorine Binding Sites List in 7o65
Chlorine binding site 2 out of 4 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl213

b:24.5
occ:1.00
 O A:HOH321 2.9 39.0 1.0
ND1 A:HIS151 2.9 16.3 1.0
ND2 A:ASN154 3.3 18.5 1.0
C A:ASP150 3.5 14.5 1.0
O A:ASP150 3.6 15.3 1.0
N A:HIS151 3.6 14.1 1.0
CE1 A:HIS151 3.7 16.2 1.0
CB A:ASP150 3.7 14.8 1.0
CA A:HIS151 3.7 13.3 1.0
CG2 A:THR174 3.9 18.6 0.6
CG A:HIS151 4.1 14.7 1.0
CE1 A:PHE170 4.1 16.1 1.0
CG2 A:THR174 4.1 15.3 0.4
O A:HOH391 4.1 37.7 1.0
CG A:ASN154 4.2 16.9 1.0
CA A:ASP150 4.3 14.8 1.0
CZ A:PHE170 4.3 16.3 1.0
CB A:ASN154 4.4 15.7 1.0
CB A:HIS151 4.5 13.6 1.0
OG1 A:THR174 4.8 14.8 0.4
OG1 A:THR174 4.9 17.4 0.6
C A:HIS151 4.9 13.7 1.0
CG A:ASP150 4.9 17.6 1.0
NE2 A:HIS151 4.9 17.8 1.0

Chlorine binding site 3 out of 4 in 7o65

Go back to Chlorine Binding Sites List in 7o65
Chlorine binding site 3 out of 4 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl214

b:35.9
occ:0.70
 ND1 A:HIS153 3.1 16.5 1.0
CE1 A:HIS153 3.9 18.1 1.0
CG A:HIS153 4.1 14.3 1.0
O A:HOH563 4.1 38.5 1.0
CA A:HIS153 4.1 15.4 1.0
CB A:HIS153 4.2 14.5 1.0
CG1 A:VAL156 4.5 17.9 1.0
CB A:VAL156 4.6 14.6 1.0
O A:HIS153 4.7 14.3 1.0
O A:HOH581 4.9 31.8 0.5
C A:HIS153 4.9 14.1 1.0

Chlorine binding site 4 out of 4 in 7o65

Go back to Chlorine Binding Sites List in 7o65
Chlorine binding site 4 out of 4 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 90 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl215

b:21.0
occ:0.70
 O A:HOH506 3.1 32.8 0.5
N A:PHE12 3.2 15.2 1.0
O A:HOH505 3.3 33.1 1.0
N A:ASN11 3.4 14.9 1.0
O A:PHE12 3.5 16.2 1.0
CG A:ARG9 3.6 15.8 1.0
NE A:ARG9 3.6 16.3 1.0
CD A:ARG9 3.7 16.2 1.0
O A:HOH465 3.7 34.5 1.0
C A:GLN10 3.9 15.4 1.0
O A:HOH538 3.9 35.8 1.0
CA A:GLN10 4.0 15.0 1.0
C A:PHE12 4.0 16.0 1.0
CA A:PHE12 4.0 15.6 1.0
N A:GLN10 4.1 13.7 1.0
CA A:ASN11 4.1 15.2 1.0
C A:ASN11 4.1 14.0 1.0
CB A:PHE12 4.3 15.8 1.0
C A:ARG9 4.4 14.9 1.0
CB A:ARG9 4.6 14.2 1.0
O A:ARG9 4.6 16.2 1.0
O A:GLN10 4.7 14.7 1.0
CZ A:ARG9 4.9 17.5 1.0

Reference:

S.Ciambellotti, A.Pratesi, G.Tassone, P.Turano, S.Mangani, C.Pozzi. Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin. Chemistry 2021.
ISSN: ISSN 0947-6539
PubMed: 34343376
DOI: 10.1002/CHEM.202102270
Page generated: Tue Jul 30 01:16:42 2024

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