Chlorine in PDB 7ooy: Purine Nucleoside Phosphorylase(Deod-Type) From H. Pylori with 6- Benzylthio-2-Chloropurine

Enzymatic activity of Purine Nucleoside Phosphorylase(Deod-Type) From H. Pylori with 6- Benzylthio-2-Chloropurine

All present enzymatic activity of Purine Nucleoside Phosphorylase(Deod-Type) From H. Pylori with 6- Benzylthio-2-Chloropurine:
2.4.2.1;

Protein crystallography data

The structure of Purine Nucleoside Phosphorylase(Deod-Type) From H. Pylori with 6- Benzylthio-2-Chloropurine, PDB code: 7ooy was solved by M.Narczyk, Z.Stefanic, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.16 / 1.90
Space group P 21 3
Cell size a, b, c (Å), α, β, γ (°) 113.591, 113.591, 113.591, 90, 90, 90
R / Rfree (%) 16.6 / 20.6

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Purine Nucleoside Phosphorylase(Deod-Type) From H. Pylori with 6- Benzylthio-2-Chloropurine (pdb code 7ooy). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Purine Nucleoside Phosphorylase(Deod-Type) From H. Pylori with 6- Benzylthio-2-Chloropurine, PDB code: 7ooy:

Chlorine binding site 1 out of 1 in 7ooy

Go back to Chlorine Binding Sites List in 7ooy
Chlorine binding site 1 out of 1 in the Purine Nucleoside Phosphorylase(Deod-Type) From H. Pylori with 6- Benzylthio-2-Chloropurine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Purine Nucleoside Phosphorylase(Deod-Type) From H. Pylori with 6- Benzylthio-2-Chloropurine within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl303

b:18.7
occ:1.00
 CL1 B:05Z303 0.0 18.7 1.0
C2 B:05Z303 1.8 18.5 1.0
N1 B:05Z303 2.6 16.6 1.0
N3 B:05Z303 2.7 18.7 1.0
CD1 B:ILE178 3.1 17.8 0.4
O B:PHE158 3.3 17.3 1.0
O B:HOH456 3.3 26.3 1.0
CG2 B:ILE178 3.4 20.3 0.6
CG B:MET180 3.7 14.7 1.0
CG2 B:ILE178 3.8 16.2 0.4
O B:HOH450 3.8 15.1 1.0
CA B:PHE159 3.8 13.3 1.0
C6 B:05Z303 3.9 21.9 1.0
O B:GLU179 3.9 15.4 1.0
C4 B:05Z303 4.0 18.1 1.0
C B:GLU179 4.0 17.4 1.0
SD B:MET180 4.0 15.2 1.0
CA B:GLU179 4.1 18.3 1.0
C B:PHE158 4.2 14.9 1.0
N B:GLU179 4.2 16.4 1.0
CG1 B:ILE178 4.2 18.2 0.4
C B:ILE178 4.2 19.1 1.0
O B:ILE178 4.3 15.9 1.0
CB B:ILE178 4.3 16.4 0.6
O B:PHE159 4.4 17.2 1.0
N B:PHE159 4.4 13.0 1.0
CD1 B:PHE159 4.4 16.9 1.0
CB B:ILE178 4.4 16.4 0.4
C5 B:05Z303 4.5 18.8 1.0
CB B:SER156 4.5 14.8 1.0
C B:PHE159 4.6 19.7 1.0
CB B:PHE159 4.7 13.9 1.0
N B:MET180 4.8 13.6 1.0
CG B:PHE159 4.8 16.4 1.0
CB B:MET180 4.9 14.4 1.0
CA B:ILE178 4.9 15.8 0.6
CA B:ILE178 5.0 15.8 0.4

Reference:

M.Narczyk, M.I.Wojtys, I.Lescic Asler, B.Zinic, M.Luic, E.K.Jagusztyn-Krynicka, Z.Stefanic, A.Bzowska. Interactions of 2,6-Substituted Purines with Purine Nucleoside Phosphorylase From Helicobacter Pylori in Solution and in the Crystal, and the Effects of These Compounds on Cell Cultures of This Bacterium. J Enzyme Inhib Med Chem V. 37 1083 2022.
ISSN: ESSN 1475-6374
PubMed: 35437103
DOI: 10.1080/14756366.2022.2061965
Page generated: Tue Jul 30 01:59:06 2024

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