Chlorine in PDB 7p0n: Crystal Structure of L-Trp/Indoleamine 2,3-Dioxygenagse 1 (HIDO1) Complex with the Jk-Loop Refined in the Open Conformation

Enzymatic activity of Crystal Structure of L-Trp/Indoleamine 2,3-Dioxygenagse 1 (HIDO1) Complex with the Jk-Loop Refined in the Open Conformation

All present enzymatic activity of Crystal Structure of L-Trp/Indoleamine 2,3-Dioxygenagse 1 (HIDO1) Complex with the Jk-Loop Refined in the Open Conformation:
1.13.11.52;

Protein crystallography data

The structure of Crystal Structure of L-Trp/Indoleamine 2,3-Dioxygenagse 1 (HIDO1) Complex with the Jk-Loop Refined in the Open Conformation, PDB code: 7p0n was solved by M.Mirgaux, J.Wouters, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.29 / 2.50
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 81.36, 114.57, 220.98, 90, 90, 90
R / Rfree (%) 21.5 / 27.9

Other elements in 7p0n:

The structure of Crystal Structure of L-Trp/Indoleamine 2,3-Dioxygenagse 1 (HIDO1) Complex with the Jk-Loop Refined in the Open Conformation also contains other interesting chemical elements:

Iron (Fe) 4 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of L-Trp/Indoleamine 2,3-Dioxygenagse 1 (HIDO1) Complex with the Jk-Loop Refined in the Open Conformation (pdb code 7p0n). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of L-Trp/Indoleamine 2,3-Dioxygenagse 1 (HIDO1) Complex with the Jk-Loop Refined in the Open Conformation, PDB code: 7p0n:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 7p0n

Go back to Chlorine Binding Sites List in 7p0n
Chlorine binding site 1 out of 2 in the Crystal Structure of L-Trp/Indoleamine 2,3-Dioxygenagse 1 (HIDO1) Complex with the Jk-Loop Refined in the Open Conformation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of L-Trp/Indoleamine 2,3-Dioxygenagse 1 (HIDO1) Complex with the Jk-Loop Refined in the Open Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl512

b:105.5
occ:1.00
OG1 C:THR351 4.5 63.2 1.0
CG C:LEU347 4.6 63.9 1.0
O C:LEU347 4.7 56.2 1.0
C C:LEU347 4.9 58.2 1.0
CB C:LEU347 4.9 59.0 1.0
CE C:LYS389 5.0 77.5 1.0

Chlorine binding site 2 out of 2 in 7p0n

Go back to Chlorine Binding Sites List in 7p0n
Chlorine binding site 2 out of 2 in the Crystal Structure of L-Trp/Indoleamine 2,3-Dioxygenagse 1 (HIDO1) Complex with the Jk-Loop Refined in the Open Conformation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of L-Trp/Indoleamine 2,3-Dioxygenagse 1 (HIDO1) Complex with the Jk-Loop Refined in the Open Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl508

b:96.6
occ:1.00
O D:ASP68 3.3 63.7 1.0
CD2 D:HIS69 3.8 66.5 1.0
C D:ASP68 4.2 63.3 1.0
CA D:HIS69 4.2 65.2 1.0
N D:HIS69 4.5 63.2 1.0
CG D:HIS69 4.6 70.1 1.0
CG2 D:THR71 4.7 65.2 1.0
NE2 D:HIS69 4.7 68.2 1.0
CB D:HIS69 4.8 67.2 1.0

Reference:

M.Mirgaux, L.Leherte, J.Wouters. Temporary Intermediates of L-Trp Along the Reaction Pathway of Human Indoleamine 2,3-Dioxygenase 1 and Identification of An Exo Site International Journal of 2021TRYPTOPHAN Research.
DOI: 10.1177/11786469211052964
Page generated: Tue Jul 30 02:13:32 2024

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