Chlorine in PDB 7pqs: SRPK1 in Complex with MSC2711186

Enzymatic activity of SRPK1 in Complex with MSC2711186

All present enzymatic activity of SRPK1 in Complex with MSC2711186:
2.7.11.1;

Protein crystallography data

The structure of SRPK1 in Complex with MSC2711186, PDB code: 7pqs was solved by M.Schroeder, M.Leiendecker, S.Knapp, Structural Genomics Consortium(Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.86 / 2.20
Space group P 65
Cell size a, b, c (Å), α, β, γ (°) 75.132, 75.132, 309.709, 90, 90, 120
R / Rfree (%) 19.9 / 23.6

Other elements in 7pqs:

The structure of SRPK1 in Complex with MSC2711186 also contains other interesting chemical elements:

Fluorine (F) 2 atoms
Sodium (Na) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the SRPK1 in Complex with MSC2711186 (pdb code 7pqs). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the SRPK1 in Complex with MSC2711186, PDB code: 7pqs:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 7pqs

Go back to Chlorine Binding Sites List in 7pqs
Chlorine binding site 1 out of 4 in the SRPK1 in Complex with MSC2711186


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of SRPK1 in Complex with MSC2711186 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl601

b:47.3
occ:1.00
CL A:80H601 0.0 47.3 1.0
C15 A:80H601 1.7 41.3 1.0
C14 A:80H601 2.7 39.6 1.0
C16 A:80H601 2.7 38.0 1.0
F A:80H601 2.9 36.0 1.0
CE1 A:HIS170 3.4 42.2 1.0
NE2 A:HIS170 3.6 41.6 1.0
CE2 A:TYR227 3.6 46.7 1.0
CD1 A:LEU231 3.6 53.1 1.0
OH A:TYR227 3.8 51.7 1.0
C13 A:80H601 4.0 39.1 1.0
C11 A:80H601 4.0 35.7 1.0
CD2 A:LEU86 4.1 47.5 1.0
ND1 A:HIS170 4.1 39.2 1.0
CZ A:TYR227 4.2 50.3 1.0
CD2 A:HIS170 4.4 40.1 1.0
C12 A:80H601 4.5 37.0 1.0
CD2 A:TYR227 4.6 46.2 1.0
CG A:HIS170 4.6 39.0 1.0

Chlorine binding site 2 out of 4 in 7pqs

Go back to Chlorine Binding Sites List in 7pqs
Chlorine binding site 2 out of 4 in the SRPK1 in Complex with MSC2711186


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of SRPK1 in Complex with MSC2711186 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl603

b:37.8
occ:1.00
O A:HOH790 2.7 66.9 1.0
N A:ASP280 3.1 33.4 1.0
N2 A:80H601 3.2 32.7 1.0
O A:HOH729 3.2 29.4 1.0
CA A:ASP280 3.6 35.5 1.0
CE2 A:PHE165 3.9 39.5 1.0
CB A:ALA279 3.9 33.1 1.0
C7 A:80H601 3.9 34.7 1.0
CZ A:PHE165 4.0 40.1 1.0
C5 A:80H601 4.0 35.0 1.0
C8 A:80H601 4.0 32.0 1.0
C18 A:80H601 4.1 32.8 1.0
C A:ALA279 4.2 32.8 1.0
NZ A:LYS109 4.2 42.2 1.0
CG2 A:VAL145 4.3 38.7 1.0
CA A:ALA279 4.3 32.3 1.0
C6 A:80H601 4.4 34.1 1.0
CB A:ASP280 4.4 37.3 1.0
CG1 A:VAL145 4.5 34.0 1.0
CD2 A:PHE165 4.5 37.6 1.0
CE1 A:PHE165 4.5 37.6 1.0
OE2 A:GLU124 4.6 38.1 1.0
CB A:VAL145 4.7 34.5 1.0
C A:ASP280 4.8 34.9 1.0
N A:LEU281 4.9 33.9 1.0

Chlorine binding site 3 out of 4 in 7pqs

Go back to Chlorine Binding Sites List in 7pqs
Chlorine binding site 3 out of 4 in the SRPK1 in Complex with MSC2711186


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of SRPK1 in Complex with MSC2711186 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl503

b:45.2
occ:1.00
CL B:80H503 0.0 45.2 1.0
C15 B:80H503 1.7 39.7 1.0
C14 B:80H503 2.7 38.4 1.0
C16 B:80H503 2.7 37.0 1.0
F B:80H503 2.9 35.6 1.0
CE1 B:HIS170 3.3 43.8 1.0
CE2 B:TYR227 3.5 47.0 1.0
NE2 B:HIS170 3.5 43.0 1.0
CD1 B:LEU231 3.6 52.1 1.0
OH B:TYR227 3.7 50.7 1.0
C13 B:80H503 4.0 36.8 1.0
C11 B:80H503 4.0 35.1 1.0
CZ B:TYR227 4.1 49.8 1.0
ND1 B:HIS170 4.1 40.8 1.0
CD2 B:LEU86 4.1 46.0 1.0
CD2 B:HIS170 4.4 41.6 1.0
C12 B:80H503 4.5 35.9 1.0
CD2 B:TYR227 4.6 46.4 1.0
CG B:HIS170 4.7 41.2 1.0
CG B:LEU231 4.9 53.4 1.0

Chlorine binding site 4 out of 4 in 7pqs

Go back to Chlorine Binding Sites List in 7pqs
Chlorine binding site 4 out of 4 in the SRPK1 in Complex with MSC2711186


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of SRPK1 in Complex with MSC2711186 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl506

b:40.1
occ:1.00
O B:HOH693 2.7 60.4 1.0
N B:ASP280 3.2 32.7 1.0
O B:HOH654 3.2 32.3 1.0
N2 B:80H503 3.2 33.4 1.0
CA B:ASP280 3.7 34.2 1.0
CB B:ALA279 3.9 33.4 1.0
CE2 B:PHE165 3.9 37.2 1.0
C5 B:80H503 3.9 35.3 1.0
C7 B:80H503 4.0 35.0 1.0
CZ B:PHE165 4.0 37.1 1.0
C18 B:80H503 4.1 32.2 1.0
C8 B:80H503 4.1 32.0 1.0
NZ B:LYS109 4.1 43.1 1.0
C B:ALA279 4.2 32.4 1.0
CG2 B:VAL145 4.2 36.6 1.0
CA B:ALA279 4.3 31.9 1.0
C6 B:80H503 4.4 34.9 1.0
CD2 B:PHE165 4.5 35.6 1.0
CG1 B:VAL145 4.5 32.3 1.0
CE1 B:PHE165 4.5 36.1 1.0
CB B:ASP280 4.6 35.9 1.0
CB B:VAL145 4.7 33.5 1.0
OE2 B:GLU124 4.7 37.0 1.0
C B:ASP280 4.9 33.9 1.0
CE B:LYS109 4.9 40.5 1.0
N B:LEU281 5.0 32.8 1.0
CG B:PHE165 5.0 35.0 1.0

Reference:

M.Schroeder, M.Leiendecker, S.Knapp. SRPK1 in Complex with MSC2711186 To Be Published.
Page generated: Fri Dec 17 08:55:59 2021

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy