Chlorine in PDB 7pw4: Human SMG1-8-9 Kinase Complex Bound to A SMG1 Inhibitor

Enzymatic activity of Human SMG1-8-9 Kinase Complex Bound to A SMG1 Inhibitor

All present enzymatic activity of Human SMG1-8-9 Kinase Complex Bound to A SMG1 Inhibitor:
2.7.11.1;

Other elements in 7pw4:

The structure of Human SMG1-8-9 Kinase Complex Bound to A SMG1 Inhibitor also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Human SMG1-8-9 Kinase Complex Bound to A SMG1 Inhibitor (pdb code 7pw4). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human SMG1-8-9 Kinase Complex Bound to A SMG1 Inhibitor, PDB code: 7pw4:

Chlorine binding site 1 out of 1 in 7pw4

Go back to Chlorine Binding Sites List in 7pw4
Chlorine binding site 1 out of 1 in the Human SMG1-8-9 Kinase Complex Bound to A SMG1 Inhibitor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human SMG1-8-9 Kinase Complex Bound to A SMG1 Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl3702

b:72.1
occ:1.00
CL39 A:88C3702 0.0 72.1 1.0
C38 A:88C3702 1.8 72.1 1.0
C37 A:88C3702 2.8 72.1 1.0
C09 A:88C3702 2.8 72.1 1.0
O07 A:88C3702 3.0 72.1 1.0
S06 A:88C3702 3.2 72.1 1.0
C05 A:88C3702 3.6 72.1 1.0
N03 A:88C3702 3.7 72.1 1.0
C04 A:88C3702 3.9 72.1 1.0
C36 A:88C3702 4.0 72.1 1.0
C10 A:88C3702 4.0 72.1 1.0
CZ2 A:TRP2207 4.5 71.0 1.0
C11 A:88C3702 4.6 72.1 1.0
O08 A:88C3702 4.6 72.1 1.0
CH2 A:TRP2207 4.7 71.0 1.0
C02 A:88C3702 4.9 72.1 1.0

Reference:

L.M.Langer, F.Bonneau, Y.Gat, E.Conti. Cryo-Em Reconstructions of Inhibitor-Bound SMG1 Kinase Reveal An Autoinhibitory State Dependent on SMG8. Elife V. 10 2021.
ISSN: ESSN 2050-084X
PubMed: 34698635
DOI: 10.7554/ELIFE.72353
Page generated: Fri Dec 17 08:55:59 2021

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