Chlorine in PDB 7qhb: Active State of GLUA1/2 in Complex with Tarp Gamma 8, L-Glutamate and Ctz

The binding sites of Chlorine atom in the Active State of GLUA1/2 in Complex with Tarp Gamma 8, L-Glutamate and Ctz (pdb code 7qhb). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Active State of GLUA1/2 in Complex with Tarp Gamma 8, L-Glutamate and Ctz, PDB code: 7qhb:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Active State of GLUA1/2 in Complex with Tarp Gamma 8, L-Glutamate and Ctz


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Active State of GLUA1/2 in Complex with Tarp Gamma 8, L-Glutamate and Ctz within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1203 b:31.2 occ:1.00 CL A:CYZ1203 0.0 31.2 1.0 C13 A:CYZ1203 1.7 31.2 1.0 N3 A:CYZ1203 2.5 31.2 1.0 C14 A:CYZ1203 2.6 31.2 1.0 C12 A:CYZ1203 2.7 31.2 1.0 CB A:LEU755 3.0 33.3 1.0 S2 A:CYZ1203 3.2 31.2 1.0 N A:ASP756 3.4 34.4 1.0 C A:LEU755 3.5 33.3 1.0 OD1 A:ASP756 3.6 34.4 1.0 CA A:LEU755 3.8 33.3 1.0 CG A:ASP756 3.9 34.4 1.0 C10 A:CYZ1203 4.0 31.2 1.0 O A:LEU755 4.0 33.3 1.0 C11 A:CYZ1203 4.0 31.2 1.0 CA A:ASP756 4.0 34.4 1.0 O4 A:CYZ1203 4.1 31.2 1.0 CG A:LEU755 4.1 33.3 1.0 OD2 A:ASP756 4.2 34.4 1.0 CD1 A:LEU755 4.2 33.3 1.0 O3 A:CYZ1203 4.2 31.2 1.0 O A:PHE491 4.3 25.3 1.0 C9 A:CYZ1203 4.5 31.2 1.0 CB A:ASP756 4.6 34.4 1.0 N A:LEU755 4.7 33.3 1.0

Chlorine binding site 2 out of 4 in the Active State of GLUA1/2 in Complex with Tarp Gamma 8, L-Glutamate and Ctz


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Active State of GLUA1/2 in Complex with Tarp Gamma 8, L-Glutamate and Ctz within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl902 b:33.1 occ:1.00 CL B:CYZ902 0.0 33.1 1.0 C13 B:CYZ902 1.7 33.1 1.0 C14 B:CYZ902 2.6 33.1 1.0 O4 B:CYZ902 2.7 33.1 1.0 C12 B:CYZ902 2.7 33.1 1.0 CB B:LEU759 3.2 36.9 1.0 S2 B:CYZ902 3.3 33.1 1.0 N B:ASP760 3.3 40.7 1.0 C B:LEU759 3.4 36.9 1.0 O B:LEU759 3.8 36.9 1.0 CA B:ASP760 3.8 40.7 1.0 N3 B:CYZ902 3.9 33.1 1.0 CA B:LEU759 3.9 36.9 1.0 C10 B:CYZ902 4.0 33.1 1.0 C11 B:CYZ902 4.0 33.1 1.0 O B:PHE495 4.2 26.9 1.0 CB B:ASP760 4.4 40.7 1.0 CG B:LEU759 4.4 36.9 1.0 C9 B:CYZ902 4.5 33.1 1.0 O3 B:CYZ902 4.6 33.1 1.0 CD2 B:LEU759 4.6 36.9 1.0 N B:LEU759 4.9 36.9 1.0 CG B:ASP760 5.0 40.7 1.0

Chlorine binding site 3 out of 4 in the Active State of GLUA1/2 in Complex with Tarp Gamma 8, L-Glutamate and Ctz


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Active State of GLUA1/2 in Complex with Tarp Gamma 8, L-Glutamate and Ctz within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl1203 b:31.2 occ:1.00 CL C:CYZ1203 0.0 31.2 1.0 C13 C:CYZ1203 1.7 31.2 1.0 N3 C:CYZ1203 2.5 31.2 1.0 C14 C:CYZ1203 2.6 31.2 1.0 C12 C:CYZ1203 2.7 31.2 1.0 CB C:LEU755 3.0 33.3 1.0 S2 C:CYZ1203 3.2 31.2 1.0 N C:ASP756 3.4 34.4 1.0 C C:LEU755 3.5 33.3 1.0 OD1 C:ASP756 3.6 34.4 1.0 CA C:LEU755 3.8 33.3 1.0 CG C:ASP756 3.9 34.4 1.0 C10 C:CYZ1203 4.0 31.2 1.0 O C:LEU755 4.0 33.3 1.0 C11 C:CYZ1203 4.0 31.2 1.0 CA C:ASP756 4.0 34.4 1.0 O4 C:CYZ1203 4.1 31.2 1.0 CG C:LEU755 4.1 33.3 1.0 OD2 C:ASP756 4.2 34.4 1.0 CD1 C:LEU755 4.2 33.3 1.0 O3 C:CYZ1203 4.2 31.2 1.0 O C:PHE491 4.3 25.3 1.0 C9 C:CYZ1203 4.5 31.2 1.0 CB C:ASP756 4.6 34.4 1.0 N C:LEU755 4.7 33.3 1.0

Chlorine binding site 4 out of 4 in the Active State of GLUA1/2 in Complex with Tarp Gamma 8, L-Glutamate and Ctz


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Active State of GLUA1/2 in Complex with Tarp Gamma 8, L-Glutamate and Ctz within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl902 b:33.1 occ:1.00 CL D:CYZ902 0.0 33.1 1.0 C13 D:CYZ902 1.7 33.1 1.0 C14 D:CYZ902 2.6 33.1 1.0 O4 D:CYZ902 2.7 33.1 1.0 C12 D:CYZ902 2.7 33.1 1.0 CB D:LEU759 3.2 36.9 1.0 S2 D:CYZ902 3.3 33.1 1.0 N D:ASP760 3.4 40.7 1.0 C D:LEU759 3.4 36.9 1.0 O D:LEU759 3.8 36.9 1.0 CA D:ASP760 3.8 40.7 1.0 N3 D:CYZ902 3.9 33.1 1.0 CA D:LEU759 3.9 36.9 1.0 C10 D:CYZ902 4.0 33.1 1.0 C11 D:CYZ902 4.0 33.1 1.0 O D:PHE495 4.2 26.9 1.0 CB D:ASP760 4.4 40.7 1.0 CG D:LEU759 4.4 36.9 1.0 C9 D:CYZ902 4.5 33.1 1.0 O3 D:CYZ902 4.6 33.1 1.0 CD2 D:LEU759 4.6 36.9 1.0 N D:LEU759 4.9 36.9 1.0

B.Herguedas, B.K.Kohegyi, J.N.Dohrke, J.F.Watson, D.Zhang, H.Ho, S.A.Shaikh, R.Lape, J.M.Krieger, I.H.Greger. Mechanisms Underlying Tarp Modulation of the GLUA1/2-Gamma 8 Ampa Receptor. Nat Commun V. 13 734 2022.
ISSN: ESSN 2041-1723
PubMed: 35136046
DOI: 10.1038/S41467-022-28404-7