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Chlorine in PDB 7qk0: Crystal Structure of Human BCL6 Btb Domain in Complex with Compound 12AProtein crystallography data
The structure of Crystal Structure of Human BCL6 Btb Domain in Complex with Compound 12A, PDB code: 7qk0
was solved by
E.A.Gunnell,
Y.-V.Le Bihan,
R.L.M.Van Montfort,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7qk0:
The structure of Crystal Structure of Human BCL6 Btb Domain in Complex with Compound 12A also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human BCL6 Btb Domain in Complex with Compound 12A
(pdb code 7qk0). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human BCL6 Btb Domain in Complex with Compound 12A, PDB code: 7qk0: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 7qk0Go back to Chlorine Binding Sites List in 7qk0
Chlorine binding site 1 out
of 2 in the Crystal Structure of Human BCL6 Btb Domain in Complex with Compound 12A
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 7qk0Go back to Chlorine Binding Sites List in 7qk0
Chlorine binding site 2 out
of 2 in the Crystal Structure of Human BCL6 Btb Domain in Complex with Compound 12A
Mono view Stereo pair view
Reference:
R.Huckvale,
A.C.Harnden,
K.J.Cheung,
O.A.Pierrat,
R.Talbot,
G.M.Box,
A.T.Henley,
A.K.De Haven Brandon,
A.E.Hallsworth,
M.D.Bright,
H.A.Akpinar,
D.S.J.Miller,
D.Tarantino,
S.Gowan,
A.Hayes,
E.A.Gunnell,
A.Brennan,
O.A.Davis,
L.D.Johnson,
S.De Klerk,
C.Mcandrew,
Y.V.Le Bihan,
M.Meniconi,
R.Burke,
V.Kirkin,
R.L.M.Van Montfort,
F.I.Raynaud,
O.W.Rossanese,
B.R.Bellenie,
S.Hoelder.
Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 in Vivo . J.Med.Chem. V. 65 8191 2022.
Page generated: Tue Apr 4 21:27:34 2023
ISSN: ISSN 0022-2623 PubMed: 35653645 DOI: 10.1021/ACS.JMEDCHEM.1C02175 |
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