Chlorine in PDB 7qn5: Cryo-Em Structure of Human Full-Length Extrasynaptic ALPHA4BETA3DELTA Gaba(A)R in Complex with Nanobody NB25

The binding sites of Chlorine atom in the Cryo-Em Structure of Human Full-Length Extrasynaptic ALPHA4BETA3DELTA Gaba(A)R in Complex with Nanobody NB25 (pdb code 7qn5). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Cryo-Em Structure of Human Full-Length Extrasynaptic ALPHA4BETA3DELTA Gaba(A)R in Complex with Nanobody NB25, PDB code: 7qn5:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Cryo-Em Structure of Human Full-Length Extrasynaptic ALPHA4BETA3DELTA Gaba(A)R in Complex with Nanobody NB25


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of Human Full-Length Extrasynaptic ALPHA4BETA3DELTA Gaba(A)R in Complex with Nanobody NB25 within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl502 b:52.6 occ:1.00 O D:HOH607 2.7 42.0 1.0 N D:SER104 3.4 43.6 1.0 ND1 C:HIS107 3.5 36.7 1.0 O D:SER104 3.5 43.6 1.0 CA C:HIS107 3.7 36.7 1.0 CE2 C:PHE105 3.7 38.5 1.0 N C:GLY108 3.8 37.7 1.0 CG C:HIS107 3.9 36.7 1.0 CB C:HIS107 3.9 36.7 1.0 NZ D:LYS103 4.0 45.7 1.0 CA D:LYS103 4.1 45.7 1.0 C D:LYS103 4.2 45.7 1.0 CA D:SER104 4.2 43.6 1.0 C C:HIS107 4.3 36.7 1.0 CE1 C:HIS107 4.3 36.7 1.0 C D:SER104 4.3 43.6 1.0 CD2 C:PHE105 4.3 38.5 1.0 CB D:SER104 4.5 43.6 1.0 OD2 D:ASP101 4.6 44.4 1.0 CD D:LYS103 4.6 45.7 1.0 CZ C:PHE105 4.7 38.5 1.0 CG D:LYS103 4.7 45.7 1.0 N C:HIS107 4.8 36.7 1.0 O D:LYS102 4.8 46.0 1.0 N D:LYS103 4.9 45.7 1.0 CD2 C:HIS107 4.9 36.7 1.0 CA C:GLY108 4.9 37.7 1.0 OG D:SER104 4.9 43.6 1.0 CE D:LYS103 5.0 45.7 1.0

Chlorine binding site 2 out of 3 in the Cryo-Em Structure of Human Full-Length Extrasynaptic ALPHA4BETA3DELTA Gaba(A)R in Complex with Nanobody NB25


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of Human Full-Length Extrasynaptic ALPHA4BETA3DELTA Gaba(A)R in Complex with Nanobody NB25 within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl503 b:52.3 occ:1.00 O C:HOH609 2.9 44.9 1.0 N C:SER104 3.2 42.7 1.0 O C:SER104 3.3 42.7 1.0 ND1 B:HIS107 3.8 38.3 1.0 N B:GLY108 3.8 39.6 1.0 CE2 B:PHE105 3.9 40.1 1.0 CA B:HIS107 3.9 38.3 1.0 NZ C:LYS103 3.9 45.1 1.0 CA C:LYS103 4.0 45.1 1.0 C C:SER104 4.0 42.7 1.0 O B:HOH536 4.1 48.3 1.0 CA C:SER104 4.1 42.7 1.0 C C:LYS103 4.1 45.1 1.0 CB B:HIS107 4.2 38.3 1.0 CG B:HIS107 4.2 38.3 1.0 CB C:SER104 4.3 42.7 1.0 C B:HIS107 4.4 38.3 1.0 CD2 B:PHE105 4.5 40.1 1.0 CD C:LYS103 4.6 45.1 1.0 CG C:LYS103 4.6 45.1 1.0 CE1 B:HIS107 4.6 38.3 1.0 OD2 C:ASP101 4.7 45.0 1.0 CZ B:PHE105 4.8 40.1 1.0 OG C:SER104 4.9 42.7 1.0 CE C:LYS103 4.9 45.1 1.0 N C:LYS103 4.9 45.1 1.0 CA B:GLY108 4.9 39.6 1.0 CB C:LYS103 4.9 45.1 1.0 O C:LYS102 5.0 46.7 1.0 N B:VAL109 5.0 40.2 1.0

Chlorine binding site 3 out of 3 in the Cryo-Em Structure of Human Full-Length Extrasynaptic ALPHA4BETA3DELTA Gaba(A)R in Complex with Nanobody NB25


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Cryo-Em Structure of Human Full-Length Extrasynaptic ALPHA4BETA3DELTA Gaba(A)R in Complex with Nanobody NB25 within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl501 b:67.7 occ:1.00 N E:ALA132 3.1 47.0 1.0 O E:ALA132 3.3 47.0 1.0 O D:HOH638 3.4 48.1 1.0 CE2 D:PHE105 3.5 41.3 1.0 CA E:SER131 3.6 49.5 1.0 ND1 D:HIS107 3.7 42.2 1.0 C E:SER131 3.8 49.5 1.0 CA D:HIS107 3.9 42.2 1.0 N D:GLY108 4.1 41.8 1.0 CD2 D:PHE105 4.1 41.3 1.0 CB E:SER131 4.1 49.5 1.0 CA E:ALA132 4.1 47.0 1.0 C E:ALA132 4.1 47.0 1.0 CG D:HIS107 4.2 42.2 1.0 CB D:HIS107 4.2 42.2 1.0 CZ D:PHE105 4.4 41.3 1.0 CE1 D:HIS107 4.4 42.2 1.0 C D:HIS107 4.6 42.2 1.0 CB E:ALA132 4.6 47.0 1.0 O E:LYS130 4.7 50.7 1.0 N E:SER131 4.7 49.5 1.0 N D:HIS107 5.0 42.2 1.0

A.Sente, R.Desai, K.Naydenova, T.Malinauskas, Y.Jounaidi, J.Miehling, X.Zhou, S.Masiulis, S.W.Hardwick, D.Y.Chirgadze, K.W.Miller, A.R.Aricescu. Differential Assembly Diversifies Gaba A Receptor Structures and Signalling. Nature V. 604 190 2022.
ISSN: ESSN 1476-4687
PubMed: 35355020
DOI: 10.1038/S41586-022-04517-3