Chlorine in PDB 7qy2: X-Ray Structure of Furin in Complex with the Dichlorophenylpyridine- Based Inhibitor 2
Enzymatic activity of X-Ray Structure of Furin in Complex with the Dichlorophenylpyridine- Based Inhibitor 2
All present enzymatic activity of X-Ray Structure of Furin in Complex with the Dichlorophenylpyridine- Based Inhibitor 2:
3.4.21.75;
3.4.21.75;
Protein crystallography data
The structure of X-Ray Structure of Furin in Complex with the Dichlorophenylpyridine- Based Inhibitor 2, PDB code: 7qy2
was solved by
S.O.Dahms,
H.Brandstetter,
A.Pautsch,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 45.89 / 1.55 |
| Space group | P 65 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 131.369, 131.369, 155.336, 90, 90, 120 |
| R / Rfree (%) | 16.5 / 18.8 |
Other elements in 7qy2:
The structure of X-Ray Structure of Furin in Complex with the Dichlorophenylpyridine- Based Inhibitor 2 also contains other interesting chemical elements:
| Sodium | (Na) | 4 atoms |
| Calcium | (Ca) | 3 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the X-Ray Structure of Furin in Complex with the Dichlorophenylpyridine- Based Inhibitor 2
(pdb code 7qy2). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the X-Ray Structure of Furin in Complex with the Dichlorophenylpyridine- Based Inhibitor 2, PDB code: 7qy2:
Jump to Chlorine binding site number: 1; 2; 3;
In total 3 binding sites of Chlorine where determined in the X-Ray Structure of Furin in Complex with the Dichlorophenylpyridine- Based Inhibitor 2, PDB code: 7qy2:
Jump to Chlorine binding site number: 1; 2; 3;
Chlorine binding site 1 out of 3 in 7qy2
Go back to
Chlorine Binding Sites List in 7qy2
Chlorine binding site 1 out
of 3 in the X-Ray Structure of Furin in Complex with the Dichlorophenylpyridine- Based Inhibitor 2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of X-Ray Structure of Furin in Complex with the Dichlorophenylpyridine- Based Inhibitor 2 within 5.0Å range:
|
Chlorine binding site 2 out of 3 in 7qy2
Go back to
Chlorine Binding Sites List in 7qy2
Chlorine binding site 2 out
of 3 in the X-Ray Structure of Furin in Complex with the Dichlorophenylpyridine- Based Inhibitor 2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of X-Ray Structure of Furin in Complex with the Dichlorophenylpyridine- Based Inhibitor 2 within 5.0Å range:
|
Chlorine binding site 3 out of 3 in 7qy2
Go back to
Chlorine Binding Sites List in 7qy2
Chlorine binding site 3 out
of 3 in the X-Ray Structure of Furin in Complex with the Dichlorophenylpyridine- Based Inhibitor 2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of X-Ray Structure of Furin in Complex with the Dichlorophenylpyridine- Based Inhibitor 2 within 5.0Å range:
|
Reference:
S.O.Dahms,
G.Schnapp,
M.Winter,
F.H.Buttner,
M.Schleputz,
C.Gnamm,
A.Pautsch,
H.Brandstetter.
Dichlorophenylpyridine-Based Molecules Inhibit Furin Through An Induced-Fit Mechanism. Acs Chem.Biol. V. 17 816 2022.
ISSN: ESSN 1554-8937
PubMed: 35377598
DOI: 10.1021/ACSCHEMBIO.2C00103
Page generated: Tue Jul 30 03:23:27 2024
ISSN: ESSN 1554-8937
PubMed: 35377598
DOI: 10.1021/ACSCHEMBIO.2C00103
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