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Chlorine in PDB 7r75: Structure of Human SHP2 in Complex with Compound 16Enzymatic activity of Structure of Human SHP2 in Complex with Compound 16
All present enzymatic activity of Structure of Human SHP2 in Complex with Compound 16:
3.1.3.48; Protein crystallography data
The structure of Structure of Human SHP2 in Complex with Compound 16, PDB code: 7r75
was solved by
P.G.Leonard,
J.Cross,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of Human SHP2 in Complex with Compound 16
(pdb code 7r75). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of Human SHP2 in Complex with Compound 16, PDB code: 7r75: Chlorine binding site 1 out of 1 in 7r75Go back to Chlorine Binding Sites List in 7r75
Chlorine binding site 1 out
of 1 in the Structure of Human SHP2 in Complex with Compound 16
Mono view Stereo pair view
Reference:
B.Czako,
Y.Sun,
T.Mcafoos,
J.B.Cross,
P.G.Leonard,
J.P.Burke,
C.L.Carroll,
N.Feng,
A.L.Harris,
Y.Jiang,
Z.Kang,
J.J.Kovacs,
P.Mandal,
B.A.Meyers,
F.Mseeh,
C.A.Parker,
S.S.Yu,
C.C.Williams,
Q.Wu,
M.E.Di Francesco,
G.Draetta,
T.Heffernan,
J.R.Marszalek,
N.E.Kohl,
P.Jones.
Discovery of 6-[(3 S ,4 S )-4-Amino-3-Methyl-2-Oxa-8-Azaspiro[4.5]Decan-8-Yl]-3-(2, 3-Dichlorophenyl)-2-Methyl-3,4-Dihydropyrimidin-4-One (Iacs-15414), A Potent and Orally Bioavailable SHP2 Inhibitor. J.Med.Chem. 2021.
Page generated: Fri Nov 5 12:41:34 2021
ISSN: ISSN 0022-2623 PubMed: 34643390 DOI: 10.1021/ACS.JMEDCHEM.1C01132 |
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