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Chlorine in PDB 7r7d: Structure of Human SHP2 in Complex with Compound 22Enzymatic activity of Structure of Human SHP2 in Complex with Compound 22
All present enzymatic activity of Structure of Human SHP2 in Complex with Compound 22:
3.1.3.48; Protein crystallography data
The structure of Structure of Human SHP2 in Complex with Compound 22, PDB code: 7r7d
was solved by
P.G.Leonard,
J.Cross,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of Human SHP2 in Complex with Compound 22
(pdb code 7r7d). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of Human SHP2 in Complex with Compound 22, PDB code: 7r7d: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 7r7dGo back to Chlorine Binding Sites List in 7r7d
Chlorine binding site 1 out
of 2 in the Structure of Human SHP2 in Complex with Compound 22
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 7r7dGo back to Chlorine Binding Sites List in 7r7d
Chlorine binding site 2 out
of 2 in the Structure of Human SHP2 in Complex with Compound 22
Mono view Stereo pair view
Reference:
B.Czako,
Y.Sun,
T.Mcafoos,
J.B.Cross,
P.G.Leonard,
J.P.Burke,
C.L.Carroll,
N.Feng,
A.L.Harris,
Y.Jiang,
Z.Kang,
J.J.Kovacs,
P.Mandal,
B.A.Meyers,
F.Mseeh,
C.A.Parker,
S.S.Yu,
C.C.Williams,
Q.Wu,
M.E.Di Francesco,
G.Draetta,
T.Heffernan,
J.R.Marszalek,
N.E.Kohl,
P.Jones.
Discovery of 6-[(3 S ,4 S )-4-Amino-3-Methyl-2-Oxa-8-Azaspiro[4.5]Decan-8-Yl]-3-(2, 3-Dichlorophenyl)-2-Methyl-3,4-Dihydropyrimidin-4-One (Iacs-15414), A Potent and Orally Bioavailable SHP2 Inhibitor. J.Med.Chem. 2021.
Page generated: Fri Nov 5 12:41:38 2021
ISSN: ISSN 0022-2623 PubMed: 34643390 DOI: 10.1021/ACS.JMEDCHEM.1C01132 |
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