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Chlorine in PDB 7r9t: Crystal Structure of HPK1 in Complex with Compound 17Enzymatic activity of Crystal Structure of HPK1 in Complex with Compound 17
All present enzymatic activity of Crystal Structure of HPK1 in Complex with Compound 17:
2.7.11.1; Protein crystallography data
The structure of Crystal Structure of HPK1 in Complex with Compound 17, PDB code: 7r9t
was solved by
P.Wu,
I.Lehoux,
W.Wang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7r9t:
The structure of Crystal Structure of HPK1 in Complex with Compound 17 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of HPK1 in Complex with Compound 17
(pdb code 7r9t). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of HPK1 in Complex with Compound 17, PDB code: 7r9t: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 7r9tGo back to Chlorine Binding Sites List in 7r9t
Chlorine binding site 1 out
of 2 in the Crystal Structure of HPK1 in Complex with Compound 17
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 7r9tGo back to Chlorine Binding Sites List in 7r9t
Chlorine binding site 2 out
of 2 in the Crystal Structure of HPK1 in Complex with Compound 17
Mono view Stereo pair view
Reference:
B.K.Chan,
E.Seward,
M.Lainchbury,
T.F.Brewer,
L.An,
T.Blench,
M.W.Cartwright,
G.K.Y.Chan,
E.F.Choo,
J.Drummond,
R.L.Elliott,
E.Gancia,
L.Gazzard,
B.Hu,
G.E.Jones,
X.Luo,
A.Madin,
S.Malhotra,
J.G.Moffat,
J.Pang,
L.Salphati,
C.J.Sneeringer,
C.E.Stivala,
B.Wei,
W.Wang,
P.Wu,
T.P.Heffron.
Discovery of Spiro-Azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1) Acs Med.Chem.Lett. 2021.
Page generated: Thu Mar 31 02:38:19 2022
ISSN: ISSN 1948-5875 DOI: 10.1021/ACSMEDCHEMLETT.1C00473 |
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