Chlorine in PDB 7ror: Plasmodium Falciparum Tyrosyl-Trna Synthetase in Complex with Tyrosine-Amp

Enzymatic activity of Plasmodium Falciparum Tyrosyl-Trna Synthetase in Complex with Tyrosine-Amp

All present enzymatic activity of Plasmodium Falciparum Tyrosyl-Trna Synthetase in Complex with Tyrosine-Amp:
6.1.1.1;

Protein crystallography data

The structure of Plasmodium Falciparum Tyrosyl-Trna Synthetase in Complex with Tyrosine-Amp, PDB code: 7ror was solved by R.D.Metcalfe, S.C.Xie, C.J.Morton, L.Tilley, M.D.W.Griffin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.65 / 1.80
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 137.612, 46.597, 141.402, 90, 93.81, 90
R / Rfree (%) 17.8 / 21.8

Other elements in 7ror:

The structure of Plasmodium Falciparum Tyrosyl-Trna Synthetase in Complex with Tyrosine-Amp also contains other interesting chemical elements:

Magnesium (Mg) 3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Plasmodium Falciparum Tyrosyl-Trna Synthetase in Complex with Tyrosine-Amp (pdb code 7ror). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Plasmodium Falciparum Tyrosyl-Trna Synthetase in Complex with Tyrosine-Amp, PDB code: 7ror:

Chlorine binding site 1 out of 1 in 7ror

Go back to Chlorine Binding Sites List in 7ror
Chlorine binding site 1 out of 1 in the Plasmodium Falciparum Tyrosyl-Trna Synthetase in Complex with Tyrosine-Amp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Plasmodium Falciparum Tyrosyl-Trna Synthetase in Complex with Tyrosine-Amp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl404

b:57.6
occ:1.00
 O A:HOH598 3.2 59.2 1.0
N A:GLU149 3.3 36.7 1.0
N A:ASN148 3.4 43.8 1.0
C A:LYS146 3.5 39.6 1.0
CA A:LYS146 3.5 38.4 1.0
CB A:ASN148 3.5 40.6 1.0
CA A:ASN148 3.8 40.9 1.0
N A:PRO147 3.8 37.3 1.0
CB A:LYS146 3.9 41.2 1.0
O A:LYS146 3.9 37.8 1.0
C A:ASN148 4.0 45.2 1.0
CB A:GLU149 4.1 42.4 1.0
CD A:PRO147 4.2 38.7 1.0
CA A:GLU149 4.3 37.8 1.0
C A:PRO147 4.4 39.8 1.0
CG A:LYS146 4.5 43.0 1.0
CA A:PRO147 4.7 38.5 1.0
CG A:ASN148 4.8 46.5 1.0
N A:LYS146 4.8 38.0 1.0
O A:LYS145 4.9 43.6 1.0
ND2 A:ASN148 4.9 52.7 1.0
CG A:PRO147 5.0 43.0 1.0

Reference:

S.C.Xie, R.D.Metcalfe, E.Dunn, C.J.Morton, S.C.Huang, T.Puhalovich, Y.Du, S.Wittlin, S.Nie, M.R.Luth, L.Ma, M.S.Kim, C.F.A.Pasaje, K.Kumpornsin, C.Giannangelo, F.J.Houghton, A.Churchyard, M.T.Famodimu, D.C.Barry, D.L.Gillett, S.Dey, C.C.Kosasih, W.Newman, J.C.Niles, M.C.S.Lee, J.Baum, S.Ottilie, E.A.Winzeler, D.J.Creek, N.Williamson, M.W.Parker, S.Brand, S.P.Langston, L.R.Dick, M.D.W.Griffin, A.E.Gould, L.Tilley. Reaction Hijacking of Tyrosine Trna Synthetase As A New Whole-of-Life-Cycle Antimalarial Strategy. Science V. 376 1074 2022.
ISSN: ESSN 1095-9203
PubMed: 35653481
DOI: 10.1126/SCIENCE.ABN0611
Page generated: Tue Jul 30 03:46:17 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy