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Chlorine in PDB 7rot: Plasmodium Falciparum Tyrosyl-Trna Synthetase, S234C Mutant, in Complex with ML901-TyrEnzymatic activity of Plasmodium Falciparum Tyrosyl-Trna Synthetase, S234C Mutant, in Complex with ML901-Tyr
All present enzymatic activity of Plasmodium Falciparum Tyrosyl-Trna Synthetase, S234C Mutant, in Complex with ML901-Tyr:
6.1.1.1; Protein crystallography data
The structure of Plasmodium Falciparum Tyrosyl-Trna Synthetase, S234C Mutant, in Complex with ML901-Tyr, PDB code: 7rot
was solved by
R.D.Metcalfe,
S.C.Xie,
C.J.Morton,
L.Tilley,
M.D.W.Griffin,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7rot:
The structure of Plasmodium Falciparum Tyrosyl-Trna Synthetase, S234C Mutant, in Complex with ML901-Tyr also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Plasmodium Falciparum Tyrosyl-Trna Synthetase, S234C Mutant, in Complex with ML901-Tyr
(pdb code 7rot). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Plasmodium Falciparum Tyrosyl-Trna Synthetase, S234C Mutant, in Complex with ML901-Tyr, PDB code: 7rot: Chlorine binding site 1 out of 1 in 7rotGo back to Chlorine Binding Sites List in 7rot
Chlorine binding site 1 out
of 1 in the Plasmodium Falciparum Tyrosyl-Trna Synthetase, S234C Mutant, in Complex with ML901-Tyr
Mono view Stereo pair view
Reference:
S.C.Xie,
R.D.Metcalfe,
E.Dunn,
C.J.Morton,
S.C.Huang,
T.Puhalovich,
Y.Du,
S.Wittlin,
S.Nie,
M.R.Luth,
L.Ma,
M.S.Kim,
C.F.A.Pasaje,
K.Kumpornsin,
C.Giannangelo,
F.J.Houghton,
A.Churchyard,
M.T.Famodimu,
D.C.Barry,
D.L.Gillett,
S.Dey,
C.C.Kosasih,
W.Newman,
J.C.Niles,
M.C.S.Lee,
J.Baum,
S.Ottilie,
E.A.Winzeler,
D.J.Creek,
N.Williamson,
M.W.Parker,
S.Brand,
S.P.Langston,
L.R.Dick,
M.D.W.Griffin,
A.E.Gould,
L.Tilley.
Reaction Hijacking of Tyrosine Trna Synthetase As A New Whole-of-Life-Cycle Antimalarial Strategy. Science V. 376 1074 2022.
Page generated: Tue Apr 4 21:36:55 2023
ISSN: ESSN 1095-9203 PubMed: 35653481 DOI: 10.1126/SCIENCE.ABN0611 |
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