Chlorine in PDB 7s9h: Cryogenic Human HSP90A-Ntd Bound to EC144

All present enzymatic activity of Cryogenic Human HSP90A-Ntd Bound to EC144:
3.6.4.10;

The structure of Cryogenic Human HSP90A-Ntd Bound to EC144, PDB code: 7s9h was solved by T.R.Stachowski, M.Vanarotti, J.Seetharaman, M.Fischer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	53.46 / 1.45
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	66.381, 90.196, 97.719, 90, 90, 90
R / Rfree (%)	15.7 / 18.4

The structure of Cryogenic Human HSP90A-Ntd Bound to EC144 also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

The binding sites of Chlorine atom in the Cryogenic Human HSP90A-Ntd Bound to EC144 (pdb code 7s9h). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Cryogenic Human HSP90A-Ntd Bound to EC144, PDB code: 7s9h:

Chlorine binding site 1 out of 1 in the Cryogenic Human HSP90A-Ntd Bound to EC144


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryogenic Human HSP90A-Ntd Bound to EC144 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl301 b:82.3 occ:0.81 CL A:7PP301 0.0 82.3 0.8 C1 A:7PP301 1.8 18.5 0.8 N5 A:7PP301 2.4 13.3 0.8 HB2 A:ALA55 2.8 18.4 1.0 HG22 A:ILE96 2.8 27.6 0.6 HB1 A:ALA55 2.9 18.4 1.0 C2 A:7PP301 2.9 15.1 0.8 HG22 A:ILE96 3.0 26.0 0.4 HG23 A:ILE96 3.1 27.6 0.6 O A:HOH454 3.1 15.3 0.8 H A:GLY97 3.1 21.3 1.0 HG23 A:ILE96 3.2 26.0 0.4 CB A:ALA55 3.3 15.3 1.0 CG2 A:ILE96 3.4 23.0 0.6 CG2 A:ILE96 3.5 21.7 0.4 HG3 A:MET98 3.6 23.8 1.0 H9A A:7PP301 3.6 29.3 0.8 N A:GLY97 3.6 17.7 1.0 O A:GLY97 3.6 19.9 1.0 C3 A:7PP301 3.7 16.4 0.8 HG1 A:THR184 3.7 25.9 1.0 C21 A:7PP301 3.7 15.2 0.8 HG21 A:ILE96 3.7 27.6 0.6 O A:HOH510 3.8 41.3 1.0 C4 A:7PP301 3.8 15.7 0.8 HA2 A:GLY97 3.8 20.7 1.0 C A:GLY97 3.9 21.2 1.0 HA A:ALA55 3.9 20.1 1.0 HG21 A:ILE96 4.0 26.0 0.4 CA A:GLY97 4.0 17.3 1.0 HB3 A:ALA55 4.0 18.4 1.0 HE2 A:MET98 4.0 30.5 1.0 C20 A:7PP301 4.0 14.2 0.8 HG2 A:MET98 4.0 23.8 1.0 H9B A:7PP301 4.1 29.3 0.8 CA A:ALA55 4.2 16.7 1.0 H A:ILE96 4.2 21.0 1.0 CG A:MET98 4.2 19.8 1.0 C5 A:7PP301 4.3 17.6 0.8 C9 A:7PP301 4.3 24.4 0.8 N3 A:7PP301 4.4 12.9 0.8 O A:HOH533 4.4 25.7 0.8 OG1 A:THR184 4.4 21.6 1.0 C A:ILE96 4.5 19.4 1.0 HN4A A:7PP301 4.5 18.3 0.8 N A:ILE96 4.6 17.5 1.0 N4 A:7PP301 4.6 15.2 0.8 N A:MET98 4.7 18.6 1.0 CB A:ILE96 4.7 18.4 0.6 CB A:ILE96 4.8 19.4 0.4 CA A:ILE96 4.8 17.0 0.6 CE A:MET98 4.8 25.4 1.0 H9 A:7PP301 4.8 29.3 0.8 CA A:ILE96 4.9 17.4 0.4 C10 A:7PP301 4.9 15.7 0.8 HA3 A:GLY97 5.0 20.7 1.0 HA A:MET98 5.0 22.7 1.0

T.R.Stachowski, M.Vanarotti, J.Seetharaman, K.Lopez, M.Fischer. Water Networks Repopulate Protein-Ligand Interfaces with Temperature. Angew.Chem.Int.Ed.Engl. V. 61 12919 2022.
ISSN: ESSN 1521-3773
PubMed: 35648650
DOI: 10.1002/ANIE.202112919