Chlorine in PDB 7ti0: Structure of Ctx-M-15 Bound to Rpx-7063 at 1.5A

All present enzymatic activity of Structure of Ctx-M-15 Bound to Rpx-7063 at 1.5A:
3.5.2.6;

The structure of Structure of Ctx-M-15 Bound to Rpx-7063 at 1.5A, PDB code: 7ti0 was solved by M.C.Clifton, J.Abendroth, S.J.Hecker, T.E.Edwards, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 1.50
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	45.88, 44.78, 117.19, 90, 90, 90
R / Rfree (%)	16 / 17.8

The binding sites of Chlorine atom in the Structure of Ctx-M-15 Bound to Rpx-7063 at 1.5A (pdb code 7ti0). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of Ctx-M-15 Bound to Rpx-7063 at 1.5A, PDB code: 7ti0:

Chlorine binding site 1 out of 1 in the Structure of Ctx-M-15 Bound to Rpx-7063 at 1.5A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Ctx-M-15 Bound to Rpx-7063 at 1.5A within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl305 b:14.0 occ:1.00 O A:HOH619 3.2 9.2 1.0 N A:ALA202 3.3 7.6 1.0 CA A:PRO201 3.7 7.3 1.0 CB A:ALA202 4.0 8.2 1.0 C A:PRO201 4.0 7.2 1.0 CB A:PRO201 4.1 7.5 1.0 CA A:ALA202 4.3 7.6 1.0 O A:HOH626 4.4 27.0 1.0 N A:PRO201 5.0 6.8 1.0

K.R.Reddy, M.Totrov, O.Lomovskaya, D.C.Griffith, Z.Tarazi, M.C.Clifton, S.J.Hecker. Broad-Spectrum Cyclic Boronate Beta-Lactamase Inhibitors Featuring An Intramolecular Prodrug For Oral Bioavailability. Bioorg.Med.Chem. V. 62 16722 2022.
ISSN: ESSN 1464-3391
PubMed: 35358864
DOI: 10.1016/J.BMC.2022.116722