Chlorine in PDB 7tnl: Complex GNGN1 of Ampa-Subtype Iglur GLUA2 in Complex with Auxiliary Subunit GAMMA2 (Stargazin) at Low Glutamate Concentration (20 Um) in the Presence of Cyclothiazide (100 Um)

The binding sites of Chlorine atom in the Complex GNGN1 of Ampa-Subtype Iglur GLUA2 in Complex with Auxiliary Subunit GAMMA2 (Stargazin) at Low Glutamate Concentration (20 Um) in the Presence of Cyclothiazide (100 Um) (pdb code 7tnl). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Complex GNGN1 of Ampa-Subtype Iglur GLUA2 in Complex with Auxiliary Subunit GAMMA2 (Stargazin) at Low Glutamate Concentration (20 Um) in the Presence of Cyclothiazide (100 Um), PDB code: 7tnl:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Complex GNGN1 of Ampa-Subtype Iglur GLUA2 in Complex with Auxiliary Subunit GAMMA2 (Stargazin) at Low Glutamate Concentration (20 Um) in the Presence of Cyclothiazide (100 Um)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Complex GNGN1 of Ampa-Subtype Iglur GLUA2 in Complex with Auxiliary Subunit GAMMA2 (Stargazin) at Low Glutamate Concentration (20 Um) in the Presence of Cyclothiazide (100 Um) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1302 b:11.3 occ:1.00 CL A:CYZ1302 0.0 11.3 1.0 C13 A:CYZ1302 1.7 11.3 1.0 C14 A:CYZ1302 2.6 11.3 1.0 C12 A:CYZ1302 2.7 11.3 1.0 O4 A:CYZ1302 3.0 11.3 1.0 N A:ASP760 3.0 60.4 1.0 CA A:ASP760 3.2 60.4 1.0 S2 A:CYZ1302 3.3 11.3 1.0 C A:LEU759 3.3 58.2 1.0 CB A:ASP760 3.3 60.4 1.0 N3 A:CYZ1302 3.6 11.3 1.0 O A:LEU759 3.6 58.2 1.0 CB A:LEU759 3.7 58.2 1.0 CG A:ASP760 3.8 60.4 1.0 C10 A:CYZ1302 4.0 11.3 1.0 C11 A:CYZ1302 4.0 11.3 1.0 OD1 A:ASP760 4.0 60.4 1.0 CA A:LEU759 4.1 58.2 1.0 OD2 A:ASP760 4.4 60.4 1.0 C9 A:CYZ1302 4.5 11.3 1.0 C A:ASP760 4.6 60.4 1.0 O3 A:CYZ1302 4.7 11.3 1.0 N A:LEU759 4.9 58.2 1.0 O A:PHE495 4.9 41.7 1.0

Chlorine binding site 2 out of 4 in the Complex GNGN1 of Ampa-Subtype Iglur GLUA2 in Complex with Auxiliary Subunit GAMMA2 (Stargazin) at Low Glutamate Concentration (20 Um) in the Presence of Cyclothiazide (100 Um)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Complex GNGN1 of Ampa-Subtype Iglur GLUA2 in Complex with Auxiliary Subunit GAMMA2 (Stargazin) at Low Glutamate Concentration (20 Um) in the Presence of Cyclothiazide (100 Um) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1301 b:58.2 occ:1.00 CL B:CYZ1301 0.0 58.2 1.0 C13 B:CYZ1301 1.7 58.2 1.0 OD1 B:ASP760 2.6 53.2 1.0 C14 B:CYZ1301 2.6 58.2 1.0 C12 B:CYZ1301 2.7 58.2 1.0 CG B:ASP760 2.8 53.2 1.0 N3 B:CYZ1301 2.9 58.2 1.0 OD2 B:ASP760 3.2 53.2 1.0 N B:ASP760 3.2 53.2 1.0 S2 B:CYZ1301 3.3 58.2 1.0 CA B:ASP760 3.6 53.2 1.0 O4 B:CYZ1301 3.6 58.2 1.0 C B:LEU759 3.7 46.1 1.0 CB B:ASP760 3.7 53.2 1.0 CB B:LEU759 3.9 46.1 1.0 C10 B:CYZ1301 4.0 58.2 1.0 C11 B:CYZ1301 4.0 58.2 1.0 O B:LEU759 4.1 46.1 1.0 CA B:LEU759 4.4 46.1 1.0 C9 B:CYZ1301 4.5 58.2 1.0 O3 B:CYZ1301 4.6 58.2 1.0 CB C:SER729 4.6 42.6 1.0

Chlorine binding site 3 out of 4 in the Complex GNGN1 of Ampa-Subtype Iglur GLUA2 in Complex with Auxiliary Subunit GAMMA2 (Stargazin) at Low Glutamate Concentration (20 Um) in the Presence of Cyclothiazide (100 Um)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Complex GNGN1 of Ampa-Subtype Iglur GLUA2 in Complex with Auxiliary Subunit GAMMA2 (Stargazin) at Low Glutamate Concentration (20 Um) in the Presence of Cyclothiazide (100 Um) within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl1302 b:23.7 occ:1.00 CL C:CYZ1302 0.0 23.7 1.0 C13 C:CYZ1302 1.7 23.7 1.0 C14 C:CYZ1302 2.6 23.7 1.0 C12 C:CYZ1302 2.7 23.7 1.0 N C:ASP760 3.0 61.5 1.0 O4 C:CYZ1302 3.1 23.7 1.0 CA C:ASP760 3.2 61.5 1.0 C C:LEU759 3.2 58.0 1.0 S2 C:CYZ1302 3.3 23.7 1.0 N3 C:CYZ1302 3.4 23.7 1.0 CB C:ASP760 3.4 61.5 1.0 O C:LEU759 3.5 58.0 1.0 CB C:LEU759 3.6 58.0 1.0 CG C:ASP760 3.9 61.5 1.0 C10 C:CYZ1302 4.0 23.7 1.0 C11 C:CYZ1302 4.0 23.7 1.0 CA C:LEU759 4.0 58.0 1.0 OD1 C:ASP760 4.1 61.5 1.0 C9 C:CYZ1302 4.5 23.7 1.0 OD2 C:ASP760 4.5 61.5 1.0 C C:ASP760 4.7 61.5 1.0 O3 C:CYZ1302 4.7 23.7 1.0 N C:LEU759 4.8 58.0 1.0 O C:PHE495 4.9 41.9 1.0 OG C:SER754 4.9 55.4 1.0 CG C:LEU759 5.0 58.0 1.0

Chlorine binding site 4 out of 4 in the Complex GNGN1 of Ampa-Subtype Iglur GLUA2 in Complex with Auxiliary Subunit GAMMA2 (Stargazin) at Low Glutamate Concentration (20 Um) in the Presence of Cyclothiazide (100 Um)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Complex GNGN1 of Ampa-Subtype Iglur GLUA2 in Complex with Auxiliary Subunit GAMMA2 (Stargazin) at Low Glutamate Concentration (20 Um) in the Presence of Cyclothiazide (100 Um) within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl1301 b:59.0 occ:1.00 CL D:CYZ1301 0.0 59.0 1.0 C13 D:CYZ1301 1.7 59.0 1.0 OD1 D:ASP760 2.6 55.3 1.0 C14 D:CYZ1301 2.6 59.0 1.0 C12 D:CYZ1301 2.7 59.0 1.0 N3 D:CYZ1301 2.8 59.0 1.0 CG D:ASP760 2.9 55.3 1.0 OD2 D:ASP760 3.2 55.3 1.0 S2 D:CYZ1301 3.3 59.0 1.0 N D:ASP760 3.4 55.3 1.0 CA D:ASP760 3.7 55.3 1.0 O4 D:CYZ1301 3.7 59.0 1.0 C D:LEU759 3.8 46.1 1.0 CB D:ASP760 3.8 55.3 1.0 C10 D:CYZ1301 4.0 59.0 1.0 CB D:LEU759 4.0 46.1 1.0 C11 D:CYZ1301 4.0 59.0 1.0 O D:LEU759 4.2 46.1 1.0 C9 D:CYZ1301 4.5 59.0 1.0 CA D:LEU759 4.5 46.1 1.0 O3 D:CYZ1301 4.6 59.0 1.0 CB A:SER729 4.6 40.0 1.0

M.V.Yelshanskaya, D.S.Patel, C.M.Kottke, M.G.Kurnikova, A.I.Sobolevsky. Opening of Glutamate Receptor Channel to Subconductance Levels. Nature V. 605 172 2022.
ISSN: ESSN 1476-4687
PubMed: 35444281
DOI: 10.1038/S41586-022-04637-W