Chlorine in PDB 7tuy: Cryo-Em Structure of GSK682753A-Bound EBI2/GPR183

The binding sites of Chlorine atom in the Cryo-Em Structure of GSK682753A-Bound EBI2/GPR183 (pdb code 7tuy). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Cryo-Em Structure of GSK682753A-Bound EBI2/GPR183, PDB code: 7tuy:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Cryo-Em Structure of GSK682753A-Bound EBI2/GPR183


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of GSK682753A-Bound EBI2/GPR183 within 5.0Å range: probe atom residue distance (Å) B Occ R:Cl1301 b:172.4 occ:1.00 CL01 R:KKF1301 0.0 172.4 1.0 C23 R:KKF1301 1.7 172.4 1.0 C25 R:KKF1301 2.6 172.4 1.0 C20 R:KKF1301 2.7 172.4 1.0 CE1 R:HIS281 2.9 175.1 1.0 CL02 R:KKF1301 3.0 172.4 1.0 ND1 R:HIS281 3.1 175.1 1.0 CB R:MET34 3.3 186.8 1.0 CE R:MET34 3.7 186.8 1.0 CG R:MET34 3.7 186.8 1.0 C24 R:KKF1301 3.9 172.4 1.0 C18 R:KKF1301 4.0 172.4 1.0 NE2 R:HIS281 4.1 175.1 1.0 CG R:HIS281 4.4 175.1 1.0 C21 R:KKF1301 4.4 172.4 1.0 CE2 R:TYR38 4.5 174.4 1.0 SD R:MET34 4.6 186.8 1.0 CA R:MET34 4.7 186.8 1.0 CD2 R:HIS281 4.9 175.1 1.0 CD2 R:TYR38 5.0 174.4 1.0

Chlorine binding site 2 out of 3 in the Cryo-Em Structure of GSK682753A-Bound EBI2/GPR183


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of GSK682753A-Bound EBI2/GPR183 within 5.0Å range: probe atom residue distance (Å) B Occ R:Cl1301 b:172.4 occ:1.00 CL02 R:KKF1301 0.0 172.4 1.0 C25 R:KKF1301 1.7 172.4 1.0 C23 R:KKF1301 2.7 172.4 1.0 C24 R:KKF1301 2.7 172.4 1.0 CL01 R:KKF1301 3.0 172.4 1.0 OH R:TYR184 3.1 186.7 1.0 CE2 R:TYR90 3.8 187.9 1.0 CE2 R:TYR184 3.8 186.7 1.0 CZ R:TYR184 3.9 186.7 1.0 C20 R:KKF1301 4.0 172.4 1.0 C21 R:KKF1301 4.0 172.4 1.0 CD2 R:TYR90 4.0 187.9 1.0 CE R:MET34 4.2 186.8 1.0 CZ R:TYR90 4.3 187.9 1.0 CG R:MET34 4.5 186.8 1.0 C18 R:KKF1301 4.6 172.4 1.0 CG R:TYR90 4.7 187.9 1.0 OH R:TYR90 4.8 187.9 1.0 ND1 R:HIS281 4.8 175.1 1.0 CE1 R:HIS281 4.9 175.1 1.0 SD R:MET34 5.0 186.8 1.0 CE1 R:TYR90 5.0 187.9 1.0

Chlorine binding site 3 out of 3 in the Cryo-Em Structure of GSK682753A-Bound EBI2/GPR183


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Cryo-Em Structure of GSK682753A-Bound EBI2/GPR183 within 5.0Å range: probe atom residue distance (Å) B Occ R:Cl1301 b:172.4 occ:1.00 CL03 R:KKF1301 0.0 172.4 1.0 C31 R:KKF1301 1.7 172.4 1.0 C29 R:KKF1301 2.7 172.4 1.0 C30 R:KKF1301 2.7 172.4 1.0 O R:LEU197 3.9 167.3 1.0 CG R:LEU197 4.0 167.3 1.0 CA R:LEU197 4.0 167.3 1.0 C27 R:KKF1301 4.0 172.4 1.0 C28 R:KKF1301 4.0 172.4 1.0 CB R:LEU197 4.3 167.3 1.0 C R:LEU197 4.4 167.3 1.0 CD2 R:LEU166 4.5 160.2 1.0 C26 R:KKF1301 4.6 172.4 1.0 CD1 R:LEU197 4.6 167.3 1.0 CB R:ALA200 4.7 155.3 1.0 CG2 R:ILE254 4.8 155.8 1.0 OH R:TYR116 4.9 139.3 1.0

H.Chen, W.Huang, X.Li. Structures of Oxysterol Sensor EBI2/GPR183, A Key Regulator of the Immune Response. Structure V. 30 1016 2022.
ISSN: ISSN 0969-2126
PubMed: 35537452
DOI: 10.1016/J.STR.2022.04.006